Isopropyl 2-(3-Nitrobenzylidene)Acetoacetate Bulk Price 2026
- Market Outlook: Stable pricing projected for 2026 due to optimized raw material sourcing and scaled production capacity.
- Quality Standard: Guaranteed >98.5% HPLC purity suitable for pharmaceutical-grade calcium channel blocker synthesis.
- Procurement: Volume-based tiers available with flexible FOB terms for international logistics.
The pharmaceutical intermediate market is increasingly demanding precise specifications for key precursors used in cardiovascular medication production. Isopropyl 2-(3-Nitrobenzylidene)acetoacetate, registered under CAS 39562-25-9, represents a critical building block in this sector. As we approach 2026, understanding the bulk price dynamics and technical specifications of this compound is essential for procurement managers and process chemists alike. This analysis provides a comprehensive overview of the manufacturing capabilities, pricing structures, and logistical terms offered by NINGBO INNO PHARMCHEM CO.,LTD., ensuring supply chain security for large-scale operations.
Technical Specifications and Synthesis Overview
From a process chemistry perspective, the quality of 2-(3-nitrobenzylidene)acetoacetate derivatives is dictated by the efficiency of the condensation reaction and subsequent purification steps. The compound is formally known as Isopropyl 2-(3-nitrobenzylidene)-3-oxobutanoate, reflecting its beta-keto ester structure. High-quality production requires a controlled Knoevenagel condensation between 3-nitrobenzaldehyde and isopropyl acetoacetate. The choice of catalyst and solvent system significantly impacts the final impurity profile, particularly regarding residual aldehydes and self-condensation byproducts.
At NINGBO INNO PHARMCHEM CO.,LTD., the synthesis route is optimized to maximize yield while minimizing hazardous waste. Typical industrial processes achieve yields exceeding 85% through careful temperature regulation during the exothermic condensation phase. Following the reaction, the crude product undergoes rigorous recrystallization. Common solvent systems include ethanol or isopropanol blends, which effectively remove unreacted starting materials and oligomeric impurities. The resulting industrial purity consistently meets or exceeds 98.5% as verified by High-Performance Liquid Chromatography (HPLC).
Primary Application: Calcium Channel Blocker Synthesis
The primary commercial utility of this intermediate lies in its role as a Nilvadipine intermediate. Nilvadipine is a dihydropyridine calcium antagonist used to treat hypertension and cerebral infarction. The structural integrity of the nitrobenzylidene moiety is crucial for the subsequent cyclization steps in the Hantzsch synthesis. Any deviation in purity can lead to downstream processing failures or reduced efficacy in the final active pharmaceutical ingredient (API). Therefore, sourcing from a verified global manufacturer with strict quality control protocols is non-negotiable for API producers.
Volume-Based Pricing Tiers for 2026
Pricing for fine chemical intermediates is heavily dependent on order volume, raw material volatility, and purification requirements. For the 2026 fiscal year, market analysis suggests stable pricing due to established supply chains for nitrobenzaldehyde derivatives. The following table outlines the estimated tiered pricing structure for bulk procurement. These figures are indicative and subject to final negotiation based on specific purity requirements and packaging preferences.
| Order Volume | Price Range (USD/kg) | Packaging | Lead Time |
|---|---|---|---|
| 25 kg - 100 kg | Consult for Quote | Fiber Drum / Aluminum Foil Bag | 7-10 Days |
| 100 kg - 500 kg | Competitive Tier 1 | 25 kg Fiber Drums | 10-15 Days |
| 500 kg - 1 MT | Competitive Tier 2 | 25 kg Fiber Drums / Palletized | 15-20 Days |
| > 1 MT | Contract Pricing | Bulk Bags / Custom ISO Tank | Negotiated |
It is important to note that prices fluctuate based on the cost of upstream petrochemical derivatives. Long-term supply agreements often lock in rates to protect against market volatility. When evaluating potential partners, buyers should consider the total cost of ownership, which includes purity guarantees and technical support. For those seeking a reliable chemical supplier capable of meeting these rigorous standards, verifying the Certificate of Analysis (COA) against internal specifications is a critical step before finalizing contracts.
FOB and Shipping Terms
International logistics play a pivotal role in the total landed cost of pharmaceutical intermediates. NINGBO INNO PHARMCHEM CO.,LTD. operates primarily under Free On Board (FOB) terms from major Chinese ports, including Ningbo and Shanghai. This allows the buyer to control freight forwarding and insurance, ensuring transparency in shipping costs. However, CIF (Cost, Insurance, and Freight) options are available upon request for specific destinations.
Documentation and Compliance
Every shipment is accompanied by comprehensive documentation to ensure smooth customs clearance and regulatory compliance. This includes:
- Certificate of Analysis (COA): Detailing HPLC purity, melting point, and residual solvent data.
- Material Safety Data Sheet (MSDS): Compliant with GHS standards for safe handling and transport.
- Packing List and Commercial Invoice: Required for customs valuation and inspection.
Proper packaging is essential to maintain stability during transit. The product is light-sensitive and should be protected from UV exposure. Standard packaging involves double-lined polyethylene bags within fiber drums, sealed to prevent moisture ingress. For larger volumes, bulk bags or isotank containers are utilized to reduce packaging waste and handling costs.
Request Bulk Quote
Securing the best value for Isopropyl 2-(3-Nitrobenzylidene)Acetoacetate requires direct communication regarding specific technical needs. Standard off-the-shelf specifications may not align with every process chemistry workflow. Custom purification levels, such as removing specific isomers or reducing heavy metal content below ppm thresholds, can be accommodated through dedicated production runs.
To initiate the procurement process for 2026 supply, buyers should submit a Request for Quotation (RFQ) detailing the required volume, target purity, and destination port. Early engagement allows for better production scheduling and ensures availability during peak demand periods. By partnering with an established manufacturer, pharmaceutical companies can mitigate supply chain risks and maintain consistent production schedules for vital cardiovascular medications.
In conclusion, the market for CAS 39562-25-9 remains robust, driven by the sustained demand for antihypertensive therapies. With a focus on high-yield synthesis, rigorous quality control, and transparent commercial terms, suppliers are well-positioned to meet the evolving needs of the global pharmaceutical industry. Prioritizing technical compatibility and logistical reliability will define successful procurement strategies in the coming year.