2-Amino-4'-Fluorobenzophenone Bulk Price Global Manufacturer
- Technical Grade Supply: Consistent industrial purity ≥98.0% verified by GC and HPLC.
- Cost Efficiency: Significant bulk price reductions available for metric ton commitments.
- Regulatory Compliance: Full COA documentation and adherence to GMP standard protocols.
In the competitive landscape of pharmaceutical intermediates, securing a reliable supply chain for key starting materials is critical for maintaining production schedules and cost margins. 2-Amino-4'-fluorobenzophenone (CAS: 3800-06-4) serves as a vital building block in the synthesis of high-value active pharmaceutical ingredients (APIs), most notably as a Rosuvastatin precursor. For procurement officers and process chemists, understanding the technical specifications and commercial dynamics of this compound is essential for effective sourcing.
As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. specializes in the large-scale production of fluorinated benzophenone derivatives. Unlike laboratory-scale suppliers who focus on gram-level quantities for research, industrial manufacturers prioritize reaction yields, purification scalability, and logistics stability. This article details the technical parameters, pricing structures, and supply capabilities required for successful bulk procurement.
Wholesale Pricing Tiers for Bulk Orders
Market analysis indicates a sharp disparity between small-scale research pricing and industrial bulk rates. While laboratory suppliers may charge premium rates for gram-level quantities, established manufacturing partners offer substantial economies of scale. The bulk price for 2-Amino-4'-fluorobenzophenone is heavily influenced by raw material costs, specifically fluorobenzene and anthranilic acid derivatives, as well as energy consumption during the acylation process.
Procurement strategies should focus on long-term contracts to lock in pricing stability. Below is a representative table outlining typical pricing tiers based on order volume. Note that final quotations depend on current market volatility and specific purity requirements.
| Order Quantity | Unit Price Trend | Lead Time | Documentation |
|---|---|---|---|
| 1 kg - 10 kg | High (Sample Scale) | 3-5 Days | Standard COA |
| 25 kg - 100 kg | Moderate | 7-14 Days | Full QC Report |
| 500 kg - 1 MT | Competitive | 15-30 Days | Batch Record + COA |
| > 1 MT | Optimized (Contract) | Negotiated | Audit Support |
For organizations evaluating suppliers for 2-Amino-4-fluorobenzophenone, it is imperative to request quotes that include freight terms (FOB/CIF) and payment structures. Industrial contracts often utilize letter of credit (LC) terms for large shipments to mitigate financial risk.
Evaluating Global Manufacturer Supply Capabilities
Technical due diligence is as important as commercial negotiation. When assessing a vendor, buyers must verify the synthesis route employed. The most common industrial method involves the Friedel-Crafts acylation of fluorobenzene with anthranilic acid derivatives, followed by cyclization and amination. The efficiency of this route directly impacts the industrial purity of the final product.
Impurities such as residual solvents, heavy metals, and isomeric byproducts must be strictly controlled. High-performance liquid chromatography (HPLC) and gas chromatography (GC) are standard methods for verifying purity levels ≥98.0%. Additionally, physical properties such as melting point (typically around 129°C) and appearance (yellow crystalline powder) serve as quick identity checks upon receipt.
Technical Specifications Overview
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 3800-06-4 | - |
| Molecular Formula | C13H10FNO | - |
| Molecular Weight | 215.22 g/mol | - |
| Assay (Purity) | ≥ 98.0% | GC / HPLC |
| Melting Point | 128°C - 130°C | DSC / Capillary |
| Appearance | Yellow Crystalline Powder | Visual |
| Loss on Drying | ≤ 0.5% | Karl Fischer |
Storage conditions are critical for maintaining stability over time. The material should be stored in a cool, dry place, ideally below 20°C, in sealed containers to prevent moisture uptake. For long-term storage of bulk quantities, nitrogen blanketing is recommended to prevent oxidation of the amino group.
Requesting Quotes for Industrial Quantities
Engaging with a top-tier supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to consistent quality and reliable logistics. The procurement process typically begins with a Request for Quotation (RFQ) detailing the required quantity, destination port, and specific quality standards. New corporate customers may undergo an onboarding process to verify business legitimacy and intended use cases, ensuring compliance with international trade regulations.
Buyers should expect comprehensive documentation with every shipment. This includes a Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and method validation reports. For pharmaceutical applications, suppliers may also provide DMF (Drug Master File) support or audit readiness documentation to facilitate regulatory filings.
In summary, securing a stable supply of this Rosuvastatin precursor requires a partner capable of delivering both technical excellence and commercial flexibility. By focusing on industrial purity, verified synthesis route data, and transparent bulk price structures, pharmaceutical manufacturers can optimize their production costs while maintaining rigorous quality standards. Partnering with a dedicated global manufacturer ensures that supply chain disruptions are minimized, allowing for uninterrupted API synthesis.