3-Bromo-4-Methylbenzotrifluoride Bulk Price Global Manufacturer 2026
- Technical Specification: CAS 66417-30-9, Molecular Weight 239.03 g/mol, Industrial Purity >98%.
- Procurement Focus: Volume-based pricing tiers available for kilogram to metric ton scale.
- Supply Chain: Reliable global manufacturer logistics with compliant hazmat shipping (UN 3261).
In the evolving landscape of pharmaceutical and agrochemical synthesis, the demand for specialized fluorinated intermediates continues to surge into 2026. Among these, 3-Bromo-4-Methylbenzotrifluoride stands out as a critical aryl bromide intermediate utilized extensively in cross-coupling reactions. For procurement managers and process chemists, securing a stable supply chain from a verified global manufacturer is paramount to maintaining production schedules and cost efficiency. This analysis details the technical specifications, synthesis viability, and commercial pricing structures required for bulk acquisition.
Technical Specifications and Industrial Purity
Understanding the physicochemical properties of this compound is essential for process scaling. With a molecular formula of C8H6BrF3, this compound serves as a robust fluorinated building block for introducing trifluoromethyl groups into complex organic architectures. The presence of the bromine atom at the 3-position relative to the methyl group allows for selective functionalization, making it highly valuable in medicinal chemistry campaigns.
Industrial standards dictate that bulk supplies must meet stringent purity thresholds to minimize downstream purification costs. High-quality batches typically exhibit a purity profile exceeding 98%, verified through GC-MS and NMR spectroscopy. The following table outlines the standard physical properties expected from a reputable supplier:
| Property | Specification |
|---|---|
| CAS Registry Number | 66417-30-9 |
| Molecular Weight | 239.03 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 65-66 °C @ 5 mmHg |
| Density | 1.546 g/cm³ |
| Refractive Index | 1.4904 @ 20 °C |
| Storage Conditions | Keep container tightly closed in a dry, cool place |
Maintaining this level of industrial purity requires advanced distillation techniques under vacuum to separate isomers and residual starting materials. Impurities such as unreacted toluene derivatives or poly-brominated side products can significantly impact reaction yields in subsequent Suzuki or Buchwald-Hartwig couplings. Therefore, requesting a Certificate of Analysis (COA) with impurity profiles is standard practice during vendor qualification.
Synthesis Route and Manufacturing Process
The commercial viability of this intermediate depends heavily on the efficiency of the synthesis route. Typically, production involves the bromination of 4-methylbenzotrifluoride using elemental bromine or N-bromosuccinimide (NBS) in the presence of a Lewis acid catalyst. Controlling the regioselectivity to favor the 3-bromo isomer over the 2-bromo isomer is the primary technical challenge in manufacturing.
Advanced manufacturers utilize continuous flow chemistry or optimized batch reactors to manage the exothermic nature of the bromination process. This ensures consistent quality and safety while maximizing yield. For buyers evaluating potential partners, understanding the manufacturer's capacity to scale this process from pilot plant to multi-ton production is crucial. When sourcing high-purity 3-Bromo-4-methylbenzotrifluoride, buyers should prioritize suppliers who demonstrate control over regioselectivity and waste management protocols.
NINGBO INNO PHARMCHEM CO.,LTD. has established itself as a premier partner in this sector, offering custom synthesis capabilities that align with GMP standard requirements for pharmaceutical intermediates. Their focus on process optimization ensures that the bulk price remains competitive without compromising on chemical integrity.
Volume-Based Pricing Tiers and Market Trends
Pricing for fluorinated aromatics is influenced by raw material costs, specifically trifluorotoluene derivatives and bromine sources. Market analysis for 2026 indicates a stabilization in prices due to improved supply chain resilience, though small-scale laboratory purchases remain significantly higher per unit weight compared to industrial contracts.
Procurement strategies should leverage volume tiers to optimize budget allocation. The following table provides a generalized overview of pricing structures observed in the B2B market:
| Quantity Tier | Estimated Price Range (USD) | Availability |
|---|---|---|
| 100g - 500g (Lab Scale) | $150 - $250 per unit | Immediate Stock |
| 1 kg - 5 kg (Pilot Scale) | $500 - $1,200 per kg | 1-2 Weeks |
| 25 kg - 100 kg (Production) | Request Quote (Volume Discount) | 3-4 Weeks |
| 1 Metric Ton+ (Bulk) | Contract Pricing | Custom Lead Time |
It is important to note that spot prices for smaller quantities often include premiums for packaging and handling. For long-term projects, negotiating a fixed-price contract for annual volumes is recommended to hedge against market volatility. NINGBO INNO PHARMCHEM CO.,LTD. offers flexible commercial terms for bulk procurement, ensuring that large-scale manufacturing runs are not interrupted by supply shortages.
Logistics, Safety, and Lead Times
As a corrosive and lachrymatory substance, proper handling and shipping classification are non-negotiable. The compound is typically classified under UN 3261 (Corrosive liquid, acidic, organic, n.o.s.), requiring Packing Group III compliance. Export documentation must include Safety Data Sheets (SDS) compliant with GHS standards, along with TSCA status verification for shipments entering the United States.
Lead times vary based on the customization required. Standard grades are often available for immediate dispatch within key global hubs. However, specific purity adjustments or isotopic labeling may require a dedicated production campaign. A reliable global manufacturer will provide transparent tracking and ensure that all packaging meets IATA/IMDG regulations for air and sea freight.
Conclusion
Securing a reliable source for 3-Bromo-4-Methylbenzotrifluoride is a strategic decision that impacts the efficiency of downstream synthetic processes. By prioritizing suppliers who offer verified industrial purity, transparent pricing models, and robust logistics support, organizations can mitigate risk and ensure continuity. With the market moving towards 2026, partnering with an established entity like NINGBO INNO PHARMCHEM CO.,LTD. provides the technical expertise and supply chain stability necessary for successful commercialization of fluorinated pharmaceuticals and agrochemicals.