Industrial Purity 2-Amino-5-Ethylphenol Hcl Specs for Bulk Procurement
- High-purity grades exceeding 99.0% via HPLC analysis for cosmetic applications.
- Strict heavy metal control ensuring compliance with global safety standards.
- Verified COA data and scalable manufacturing processes for industrial supply.
In the competitive landscape of cosmetic chemistry, the reliability of raw materials dictates the safety and efficacy of the final product. 2-Amino-5-ethylphenol hydrochloride (CAS: 149861-22-3) serves as a critical intermediate in the formulation of oxidative hair dyes. For procurement managers and chemical engineers, understanding the nuanced specifications beyond basic CAS identification is essential. This compound, with the molecular formula C8H12ClNO, requires stringent quality control to ensure consistent coloring performance and consumer safety. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. prioritizes technical transparency and batch consistency to support large-scale industrial production.
HPLC Purity Standards Above 99.0 Percent
Market availability for this intermediate often varies between standard laboratory grades and true industrial purity. While some suppliers offer materials at 95% purity, high-end cosmetic formulations demand specifications exceeding 99.0% as determined by High-Performance Liquid Chromatography (HPLC). The presence of isomeric impurities or unreacted starting materials can significantly alter the shade development and stability of hair dye formulations.
Achieving industrial purity requires advanced crystallization techniques and rigorous solvent management during the final processing stages. At NINGBO INNO PHARMCHEM CO.,LTD., production batches are subjected to dual-detector HPLC analysis to quantify trace impurities. This ensures that the 2-Amino-5-ethylphenol HCl supplied meets the strict thresholds required for regulatory compliance in major markets. Buyers should prioritize suppliers who provide chromatograms alongside their certificates, as this data validates the absence of closely related phenolic byproducts that could compromise product safety.
Low Metal Impurity Profiles for Hair Dyes
Given the direct application of this chemical on human keratin structures, heavy metal content is a non-negotiable specification. Regulatory bodies impose strict limits on lead, arsenic, mercury, and cadmium residues. Standard technical grades may contain elevated metal levels due to catalyst residues from the synthesis route. However, pharmaceutical and cosmetic grades must undergo additional purification steps, such as chelation or specialized filtration, to reduce metal content to parts-per-million (ppm) levels.
Our manufacturing process incorporates inductively coupled plasma mass spectrometry (ICP-MS) screening for every production lot. This level of scrutiny ensures that the material is safe for use in personal care products. Storage conditions also play a vital role in maintaining stability; the compound is hygroscopic and should be stored under inert gas (nitrogen or argon) at 2-8°C to prevent oxidation and degradation, which can introduce unforeseen impurities over time.
Verifying COA Data Against Lab Grades
A Certificate of Analysis (COA) is the primary document for verifying quality, yet not all COAs are created equal. Laboratory-grade certificates often list broad ranges for assay values, whereas industrial procurement requires specific batch data. When evaluating a supplier, it is crucial to cross-reference the COA melting point data with physical samples. The typical melting point for this substance is >163°C (dec.). Deviations from this range often indicate solvent retention or salt stoichiometry issues.
Furthermore, solubility profiles should be confirmed. The material is slightly soluble in DMSO and Methanol. Inconsistencies here can signal purity issues. Reliable partners provide comprehensive documentation that includes not just the assay percentage, but also detailed loss on drying (LOD) and residue on ignition (ROI) metrics. This transparency is vital for quality assurance teams validating incoming raw materials against internal standards.
Manufacturing Process and Scalability
The manufacturing process for 2-Amino-5-ethylphenol hydrochloride involves precise control over reaction kinetics to maximize yield while minimizing byproduct formation. Scalability is a key consideration for buyers securing long-term supply contracts. A process that works efficiently on a kilogram scale may face thermal management challenges when scaled to tons.
Efficient production lines utilize continuous flow chemistry or optimized batch reactors to maintain consistent thermal profiles. This control is essential for maintaining the structural integrity of the amine and phenol functionalities within the molecule. When sourcing high-purity 2-Amino-5-Ethylphenol Hydrochloride, buyers should evaluate the supplier's capacity to scale production without compromising the strict purity parameters established during the pilot phase.
Commercial Specifications and Bulk Pricing
Procurement strategies for fine chemicals must balance cost with quality assurance. While spot market prices for small gram quantities can be exorbitant, established contracts for metric tonnage offer significant economies of scale. The bulk price is heavily influenced by the purity grade and the accompanying documentation package. Investors in cosmetic manufacturing should anticipate that higher purity grades command a premium but reduce the risk of batch rejection during final product testing.
The following table outlines the typical technical specifications expected for industrial-grade procurement:
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 149861-22-3 | N/A |
| Molecular Formula | C8H12ClNO | N/A |
| Molecular Weight | 173.64 g/mol | N/A |
| Assay (HPLC) | > 99.0% | Area Normalization |
| Melting Point | > 163°C (dec.) | Capillary Method |
| Appearance | White to Light Brown Solid | Visual |
| Heavy Metals | < 10 ppm | ICP-MS |
| Loss on Drying | < 0.5% | Karl Fischer / LOD |
Secure supply chains are built on trust and verified data. By partnering with a dedicated chemical manufacturer, companies can ensure that their raw material inputs remain consistent across production cycles. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to delivering high-specification intermediates that empower the global cosmetics industry to innovate safely and efficiently.