Industrial Purity Specifications for 2-(5-Chloro-2H-indazol-3-yl)acetic Acid
- CAS Registry: 27328-68-3 with verified molecular formula C9H7ClN2O2.
- Quality Standard: Agrochemical and pharmaceutical grade purity exceeding 98% via HPLC.
- Supply Chain: Bulk procurement options available from drum to tonnage scales with full COA.
In the landscape of modern agrochemical and pharmaceutical intermediates, precise chemical specifications are paramount for downstream synthesis success. 2-(5-Chloro-2H-indazol-3-yl)acetic Acid, known commonly by its CAS number 27328-68-3, serves as a critical building block for various heterocyclic compounds. Ensuring consistent industrial purity is not merely a regulatory requirement but a fundamental necessity for maintaining reaction yields and minimizing downstream purification costs. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. adheres to rigorous quality control protocols to deliver material that meets the exacting standards of process chemistry.
Chemical Properties and Structural Integrity
Understanding the physicochemical properties of this indazole derivative is essential for process engineers and procurement specialists. The molecule features a chlorinated indazole core linked to an acetic acid moiety, presenting specific solubility and reactivity profiles. The molecular weight is approximately 210.62 Da, with a structure that demands careful handling to prevent degradation or isomerization during storage.
| Property | Specification |
|---|---|
| Chemical Name | 2-(5-Chloro-2H-indazol-3-yl)acetic Acid |
| CAS Number | 27328-68-3 |
| Molecular Formula | C9H7ClN2O2 |
| Molecular Weight | 210.62 g/mol |
| Purity (HPLC) | >98.0% (Typical Industrial Grade) |
| Appearance | Off-white to Light Yellow Solid |
| Storage Conditions | Ambient, sealed under inert atmosphere if prolonged |
Variations in synonyms, such as 5-Chloro-3-(1H)indazole carboxylic acid, often appear in literature, but structural verification via NMR is critical to ensure the correct regioisomer is supplied. Impurities often arise from incomplete chlorination or hydrolysis steps during production, which can significantly impact subsequent coupling reactions.
Analytical Methods and Impurity Profiles
To guarantee industrial purity, comprehensive analytical testing is required for every batch. Standard operating procedures typically involve High-Performance Liquid Chromatography (HPLC) coupled with Mass Spectrometry (LC-MS) for identity confirmation. The primary assay method utilizes a reverse-phase column with a gradient elution system to separate the target molecule from potential regioisomers and starting materials.
Key Analytical Parameters
- Assay Method: HPLC with UV detection at 254 nm.
- Residual Solvents: GC analysis to ensure compliance with ICH Q3C guidelines.
- Heavy Metals: ICP-MS screening to meet pharmaceutical intermediate standards.
- Water Content: Karl Fischer titration to ensure stability during storage.
Every shipment is accompanied by a comprehensive COA (Certificate of Analysis) detailing these parameters. This documentation is vital for quality assurance teams validating raw materials before they enter the production line. Deviations in purity profiles can lead to catalyst poisoning in downstream hydrogenation or coupling steps, making strict adherence to specs non-negotiable.
Manufacturing Process and Synthesis Route
The efficiency of the synthesis route directly influences the cost-effectiveness and environmental footprint of the final product. Industrial-scale production typically involves the cyclization of hydrazine derivatives with appropriate beta-keto esters, followed by hydrolysis to yield the acetic acid side chain. Optimizing this manufacturing process requires precise temperature control and stoichiometry to maximize yield while minimizing hazardous waste.
Advanced reactors are employed to manage the exothermic nature of the cyclization steps. Furthermore, purification via recrystallization ensures the removal of trace organic impurities that chromatography might miss on a large scale. This robust approach allows for the consistent supply of high-quality intermediates required for complex pesticide and pharmaceutical formulations.
Commercial Procurement and Bulk Supply
For process development teams scaling up from gram to kilogram quantities, supply chain reliability is as crucial as chemical quality. Market analysis indicates significant price volatility for research-grade quantities, but stable bulk price structures are available for committed industrial partners. Procurement strategies should focus on suppliers capable of delivering tonnage quantities without compromising specification integrity.
When sourcing high-purity 2-(5-Chloro-2H-indazol-3-yl)acetic Acid, buyers should prioritize manufacturers with established logistics for hazardous materials. Typical bulk packaging includes palletized plastic drums, fiber drums, or super sacks ranging from 25 kg to 1 ton, depending on the volume required. Shipping documentation must always include the Safety Data Sheet (SDS) and the aforementioned COA to facilitate customs clearance and warehouse intake.
Packaging and Logistics Specifications
- Standard Pack: 25 kg fiber drums with polyethylene liners.
- Bulk Options: 500 kg super sacks for large-scale reactor charging.
- Shipping Class: Classified under appropriate hazard codes (e.g., H315, H319) for safe transport.
- Lead Time: Optimized production schedules ensure timely delivery for just-in-time manufacturing.
NINGBO INNO PHARMCHEM CO.,LTD. maintains a strategic inventory of key intermediates to mitigate supply chain disruptions. By integrating vertical manufacturing capabilities with rigorous quality assurance, we ensure that clients receive material that performs consistently in their specific synthetic applications. Whether for crop protection agents or medicinal chemistry programs, the reliability of the starting material defines the success of the final product.
Conclusion
Selecting the right supplier for 2-(5-Chloro-2H-indazol-3-yl)acetic Acid involves more than comparing unit costs; it requires a partnership built on technical transparency and supply security. With a focus on high industrial purity, validated synthesis routes, and reliable bulk distribution, manufacturers can secure the foundation needed for efficient chemical production. For detailed technical data sheets or custom synthesis inquiries, direct engagement with qualified production facilities ensures that all regulatory and performance criteria are met.