Bulk Price 2',3',5'-Tri-O-Acetyl-2-Fluoroadenosine Manufacturer Quote Request
- Technical Specification: CAS 15811-32-2, Molecular Formula C16H18FN5O7, Molecular Weight 411.34.
- Commercial Advantage: Significant cost reduction when transitioning from gram-scale research to kilogram-level production.
- Quality Assurance: Full documentation including COA and MSDS provided for every industrial batch.
In the competitive landscape of nucleoside analogue production, securing a reliable supply chain for key intermediates is paramount. 2',3',5'-Tri-O-acetyl-2-fluoroadenosine serves as a critical building block in the synthesis route for various antiviral and antineoplastic agents, most notably Fludarabine. For process chemists and procurement managers, understanding the nuances of industrial purity and volume-based pricing structures is essential for optimizing production costs. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier partner in this sector, offering scalable solutions that bridge the gap between laboratory research and commercial manufacturing.
This compound, often referred to technically as 2-Fluoro-2',3',5'-triacetoxyadenosine, requires precise handling during acetylation to ensure the stability of the glycosidic bond while protecting the hydroxyl groups. The market often presents a stark contrast between small-scale research pricing and true bulk manufacturing costs. While gram quantities are readily available for screening purposes, industrial clients require drum-level supply with consistent quality metrics. This article details the technical specifications, pricing tiers, and procurement protocols necessary for securing high-quality materials at competitive rates.
Technical Specifications and Synthesis Overview
The production of Adenosine 2-fluoro 2',3',5'-triacetate involves a multi-step protection strategy starting from 2-fluoroadenosine. The acetylation process must be tightly controlled to prevent depurination or over-acetylation, which can compromise the yield and purity of the final product. High-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy are standard analytical methods used to verify the structure and assess impurities.
For large-scale applications, maintaining an industrial purity level above 98% is standard, though custom synthesis options can push this higher depending on downstream processing requirements. The molecular formula C16H18FN5O7 and molecular weight of 411.34 remain constant, but the physical form and packaging differ significantly between research and production grades. Stability is generally maintained at room temperature, provided the material is kept in airtight containers away from moisture, which can hydrolyze the acetate groups.
Key Quality Metrics
When evaluating suppliers, procurement teams must verify several key data points beyond the certificate of analysis. The presence of residual solvents, heavy metals, and specific isomeric impurities can affect subsequent reaction steps. A robust manufacturing process ensures that these variables are minimized. Below is a comparison of standard specifications expected for industrial-grade material versus research-grade samples.
| Parameter | Research Grade (Gram Scale) | Industrial Grade (Kg Scale) | Testing Method |
|---|---|---|---|
| Purity | > 98% | > 98.5% (Customizable) | HPLC / NMR |
| Packaging | Glass Bottles (1g - 10g) | Aluminum Drums (25kg) | Visual / Weight |
| Documentation | Basic COA | Full COA, MSDS, Stability Data | QC Department |
| Lead Time | Immediate (Stock) | 15-30 Days (Production) | Supply Chain |
Volume-Based Pricing Tiers for 25kg Drums
The economics of nucleoside chemistry change drastically when moving from milligram synthesis to multi-kilogram production. Market analysis indicates that small-scale pricing for this Fluoroadenosine derivative can exceed $90 per gram. While acceptable for initial screening, this cost structure is unsustainable for commercial API synthesis. Bulk procurement strategies focus on reducing the cost per kilogram through optimized reaction scales and efficient purification processes.
For clients requiring 25kg drums or larger, the pricing model shifts from a premium retail structure to a wholesale manufacturing agreement. Factors influencing the final bulk price include raw material availability, solvent recovery rates, and the complexity of the final purification step. NINGBO INNO PHARMCHEM CO.,LTD. offers transparent pricing tiers that reflect these efficiencies, allowing clients to forecast budgets accurately for long-term projects.
Comparing Gram vs Bulk Cost Structures
Understanding the disparity between gram and bulk costs is vital for financial planning. Small quantities incur higher overheads per unit due to packaging, quality control sampling, and handling logistics. In contrast, bulk orders amortize these fixed costs over a larger mass of product. Additionally, bulk synthesis often allows for continuous processing techniques that improve overall yield and reduce waste.
When sourcing high-purity intermediates from a reliable global manufacturer, buyers should expect significant savings compared to catalog pricing. The transition from research scales to pilot plant scales usually reveals a cost reduction factor of 10x to 50x per kilogram, depending on the specific volume committed. This makes early engagement with manufacturing partners crucial for drug development projects aiming for commercial viability.
Requesting Formal Quote and Lead Time
To initiate a procurement process for 2',3',5'-Tri-O-acetyl-2-fluoroadenosine, potential clients should prepare a detailed request for quotation (RFQ). This document should specify the required quantity, desired purity profile, and any specific packaging requirements. Providing this information upfront allows the manufacturing team to assess feasibility and provide an accurate timeline.
Standard lead times for bulk production typically range from 15 to 30 days, depending on current queue levels and raw material stock. For urgent requirements, expedited production slots may be available upon negotiation. It is also recommended to request samples for internal validation before committing to full-scale production runs. This ensures that the material meets all internal specifications regarding solubility, reactivity, and impurity profiles.
Documentation and Compliance
Regulatory compliance is a non-negotiable aspect of pharmaceutical ingredient sourcing. Every batch supplied must be accompanied by a comprehensive Certificate of Analysis (COA) detailing the results of all quality control tests. Furthermore, a Material Safety Data Sheet (MSDS) is provided to ensure safe handling, storage, and transportation of the chemical. These documents are essential for regulatory filings and internal safety audits.
Custom synthesis services are also available for clients requiring modified specifications or alternative packaging solutions. Whether the requirement is for fast delivery of stock material or a dedicated campaign for a novel derivative, establishing a partnership with a qualified supplier ensures continuity of supply. By focusing on technical excellence and commercial flexibility, manufacturers can support the rigorous demands of modern drug discovery and development pipelines.
In conclusion, securing the right supply partner for 2',3',5'-Tri-O-acetyl-2-fluoroadenosine involves more than just comparing unit prices. It requires a deep understanding of the synthesis capabilities, quality assurance protocols, and scalability of the provider. With the right strategic partnership, companies can mitigate supply chain risks and accelerate their path to market.