Industrial Grade 4-(2-Hydroxyethylamino)-3-Nitrophenol: Purity Specs and COA Analysis
- Critical Specifications: CAS 65235-31-6 requires strict melting point control (142-146℃) and HPLC purity verification for cosmetic applications.
- Quality Assurance: Comprehensive COA documentation includes impurity profiling and heavy metal analysis to ensure regulatory compliance.
- Bulk Procurement: Industrial scale manufacturing supports tonnage supply with consistent batch-to-batch reproducibility for global formulators.
In the specialized realm of cosmetic chemistry and organic synthesis, the demand for high-grade intermediates is governed by strict regulatory standards and performance metrics. 4-(2-Hydroxyethylamino)-3-Nitrophenol, identified by CAS number 65235-31-6, serves as a critical Hair dye precursor in the formulation of semi-permanent colorants. Known commercially as HC Red B54, this Chemical intermediate requires precise manufacturing controls to ensure safety and efficacy. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. delivers this compound with the industrial purity necessary for large-scale cosmetic production.
Procuring this material involves more than simply checking a price list; it requires a deep understanding of the synthesis route, potential impurities, and stability profiles. This technical overview details the physicochemical properties, quality assurance protocols, and commercial considerations for sourcing this nitrophenol derivative.
Physicochemical Properties and Technical Specifications
Understanding the fundamental properties of 4-(2-Hydroxyethylamino)-3-Nitrophenol is essential for quality control laboratories and process engineers. The molecular structure, containing both nitro and hydroxyethylamino functional groups, dictates its reactivity and solubility profile. Below is a detailed specification table typically found in a certificate of analysis for High purity industrial grades.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 65235-31-6 | N/A |
| Molecular Formula | C8H10N2O4 | Calculated |
| Molecular Weight | 198.18 g/mol | Calculated |
| Melting Point | 142-146℃ | DSC / Capillary |
| Appearance | Yellow to Orange Crystalline Powder | Visual |
| Purity (HPLC) | > 98.0% (Industrial Grade) | HPLC Area % |
| Loss on Drying | < 0.5% | Karl Fischer / LOD |
| Heavy Metals | < 10 ppm | ICP-MS |
Maintaining the melting point within the 142-146℃ range is a primary indicator of crystalline purity. Deviations often suggest the presence of isomeric byproducts or incomplete reaction conversion during the synthesis route. Manufacturers must employ rigorous crystallization processes to remove unreacted aminophenols or over-nitrated species.
Manufacturing Process and Synthesis Route
The production of this nitrophenol derivative typically involves a nucleophilic substitution followed by controlled nitration. The process begins with the reaction of a suitable aminophenol precursor with ethylene oxide or ethanolamine derivatives. Subsequent nitration requires precise temperature control to prevent oxidative degradation of the phenol ring.
Advanced manufacturing facilities utilize hydrogenation and nitration reactors capable of handling exothermic reactions safely. The process flow includes:
- Reaction: Controlled addition of nitrating agents under low-temperature conditions to minimize dinitro formation.
- Quenching: Careful neutralization to isolate the crude product.
- Purification: Recrystallization from suitable solvents to achieve target industrial purity levels.
- Drying: Vacuum drying to ensure low moisture content, critical for stability during storage.
Process chemists must monitor the reaction closely to avoid the formation of hazardous byproducts. The ability to troubleshoot and optimize these steps distinguishes top-tier suppliers from general traders. NINGBO INNO PHARMCHEM CO.,LTD. leverages extensive experience in organic synthetic chemistry to ensure high yields and consistent quality across batches.
Understanding COA Documentation Requirements
For B2B procurement, the Certificate of Analysis (COA) is the primary document verifying quality. A robust COA for this Hair dye precursor should not only list the assay percentage but also provide an impurity profile. Key components of a compliant COA include:
- Chromatograms: HPLC or GC traces showing the main peak and any significant impurities.
- Residual Solvents: Verification that solvents used in crystallization comply with ICH Q3C guidelines.
- Microbial Limits: Essential for cosmetic raw materials to prevent contamination in final formulations.
Buyers should request batch-specific COAs before finalizing bulk orders. This ensures that the material meets the specific requirements of their formulation team. When sourcing high-purity 4-(2-Hydroxyethylamino)-3-Nitrophenol, buyers should verify that the supplier maintains full traceability from raw materials to the finished drum.
Batch Consistency and Quality Assurance Protocols
Consistency is the cornerstone of industrial chemical supply. Variations in particle size or purity can affect the dissolution rate and final color performance in hair dye applications. Quality assurance protocols involve statistical process control (SPC) to monitor critical parameters.
Regular stability testing is conducted to ensure the product remains stable under recommended storage conditions. The material should be kept in a dark place, sealed in dry conditions at room temperature. Exposure to light or moisture can lead to degradation, affecting the Stable quality required for long-term inventory management.
Safety and Handling Guidelines
Safety data is integral to the procurement process. This compound carries specific hazard classifications that must be managed during handling and transport. According to GHS standards, the material is classified with the following hazard statements:
- H302: Harmful if swallowed.
- H315: Causes skin irritation.
- H319: Causes serious eye irritation.
- H335: May cause respiratory irritation.
Precautionary statements mandate the use of protective gloves, eye protection, and face protection. Handling should occur in a well-ventilated area to avoid breathing dust or vapors. Proper disposal of contents and containers must follow local environmental regulations. Ensuring staff are trained on these safety protocols is essential for any facility processing this Chemical intermediate.
Commercial Viability and Bulk Procurement
The market for cosmetic intermediates is sensitive to supply chain reliability. While spot prices may fluctuate, long-term contracts with established manufacturers provide price stability and guaranteed supply ability. Industrial buyers should look for suppliers capable of delivering tonnage quantities without compromising on specification.
Competitive bulk price structures are often available for committed volumes, but these should never come at the expense of quality verification. The ability to provide free samples for testing prior to bulk shipment is a standard practice among reputable suppliers. This allows formulation chemists to validate performance in their specific matrix before scaling up production.
Conclusion
Sourcing 4-(2-Hydroxyethylamino)-3-Nitrophenol requires a partner who understands both the chemical intricacies and the commercial demands of the cosmetic industry. From strict melting point control to comprehensive COA documentation, every step of the supply chain impacts the final product quality. By prioritizing High purity standards and robust manufacturing processes, NINGBO INNO PHARMCHEM CO.,LTD. ensures that clients receive materials that meet the highest global standards for safety and performance.