5,6-Dimethoxy-1-Indanone Bulk Price Global Manufacturer 2026
- Market Pricing: Bulk rates significantly undercut gram-scale pricing, with industrial volumes offering optimal cost efficiency for API production.
- Technical Specs: High industrial purity grades (98%-99%) ensure consistent melting points between 118-120°C for downstream reactions.
- Supply Security: Partnering with a reliable global manufacturer mitigates logistics risks and ensures steady availability of this critical Donepezil intermediate.
The pharmaceutical landscape continues to evolve, placing heightened emphasis on the availability and cost-efficiency of key chemical building blocks. Among these, 5,6-Dimethoxy-1-Indanone (CAS: 2107-69-9) stands out as a vital precursor in the synthesis of neurotherapeutic agents. As we approach 2026, procurement managers and process chemists must navigate fluctuating market dynamics to secure reliable supply chains. NINGBO INNO PHARMCHEM CO.,LTD. positions itself as a premier partner in this sector, delivering consistent quality and competitive bulk price structures for large-scale manufacturing needs.
This compound, chemically known as 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one, is predominantly utilized in the production of Donepezil, a standard treatment for Alzheimer's disease. The stability of its supply chain directly impacts the production timelines of finished pharmaceutical products. Understanding the technical specifications and commercial variables associated with this molecule is essential for maintaining operational efficiency in organic medicinal chemistry.
Global Market Pricing Trends for 2026
Analysis of current market data reveals a significant disparity between laboratory-scale and industrial-scale pricing. Retail listings for small packaging (1g to 100g) often exhibit inflated unit costs, ranging significantly higher than bulk equivalents. For instance, small-scale acquisitions can exceed hundreds of dollars per kilogram when extrapolated, whereas industrial contracts normalize these costs.
For the 2026 fiscal year, buyers should anticipate that bulk price negotiations will hinge on purity guarantees and volume commitments. Market intelligence suggests that while spot prices for 95% purity material may appear attractive, the cost of subsequent purification steps often negates initial savings. Therefore, sourcing 98% to 99% purity material directly from a global manufacturer is generally more cost-effective for API synthesis. Strategic procurement involves locking in rates for multi-kilogram or ton-scale deliveries to hedge against raw material volatility.
Technical Specifications and Industrial Purity
From a process chemistry perspective, the physical properties of 5,6-Dimethoxy-2,3-dihydroinden-1-one are critical for reaction optimization. The compound typically presents as an off-white to pale yellow solid. Consistency in physical constants is a marker of high industrial purity and effective manufacturing processes.
Key physical parameters include:
| Property | Specification |
|---|---|
| CAS Number | 2107-69-9 |
| Molecular Formula | C11H12O3 |
| Molecular Weight | 192.21 g/mol |
| Melting Point | 118-120°C |
| Boiling Point | 139°C (at 2mmHg) |
| Density | ~1.15 g/cm³ |
| Solubility | Chloroform, Ethyl Acetate |
Deviation from the standard melting point range often indicates the presence of isomers or incomplete reaction byproducts, which can complicate downstream processing. A reliable supplier provides a comprehensive Certificate of Analysis (COA) with every batch, confirming these parameters via HPLC or GC analysis. When designing a synthesis route for Donepezil, the quality of this starting material dictates the yield and purification burden of subsequent steps.
Supply Chain Stability and Logistics Costs
Reliability is as valuable as price in the B2B chemical sector. Recent global disruptions have highlighted the risks of relying on fragmented supply networks. Some legacy suppliers have restricted shipments to specific regions, creating bottlenecks for pharmaceutical manufacturers. In contrast, established entities like NINGBO INNO PHARMCHEM CO.,LTD. maintain robust logistics channels to ensure uninterrupted delivery.
Procurement strategies should account for lead times and packaging integrity. The compound requires storage in sealed, dry conditions at room temperature to prevent degradation. Bulk shipments are typically packaged in double-lined drums or specialized containers to maintain stability during transit. Evaluating the total landed cost, including freight and insurance, is necessary when comparing quotes from different vendors.
Optimizing Procurement for Organic Synthesis
For process development teams, the integration of high-quality intermediates is non-negotiable. When sourcing high-purity organic synthesis materials, buyers should prioritize vendors who demonstrate transparency in their manufacturing processes. The ability to scale from kilogram to ton quantities without compromising quality is a defining characteristic of a top-tier supplier.
Furthermore, the versatility of 5,6-Dimethoxy-1-indanone extends beyond Donepezil. It serves as a valuable chemical building block for various heterocyclic compounds. Ensuring a steady supply allows R&D departments to explore novel derivatives without material constraints. Strategic partnerships with manufacturers who understand the nuances of pharmaceutical intermediates facilitate smoother regulatory filings and production scale-ups.
Conclusion
As the demand for neurotherapeutic agents grows, the market for 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one will remain robust. Successful procurement in 2026 requires a focus on total value rather than just unit price. By prioritizing industrial purity, supply chain reliability, and technical support, pharmaceutical companies can secure a competitive advantage. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to supporting these global needs with premium-grade intermediates and responsive service.