4-Cyanobenzyl Chloride Bulk Price Global Manufacturer: Technical Specifications and Supply Chain Analysis
- Chemical Identity: CAS 874-86-2, also known as 4-(Chloromethyl)benzonitrile, requires strict moisture control during storage.
- Purity Standards: Industrial purity typically exceeds 98%, verified by HPLC and GC analysis for pharmaceutical applications.
- Procurement: Bulk price tiers depend on volume, packaging (25kg drums), and logistics capabilities of the global manufacturer.
In the landscape of fine chemicals and pharmaceutical intermediates, securing a reliable supply chain for reactive building blocks is critical for process chemistry teams. 4-Cyanobenzyl Chloride (CAS 874-86-2) serves as a vital precursor in the synthesis of various bioactive molecules, including angiotensin II AT2 receptor agonists and allosteric glucokinase activators. As demand scales for these downstream therapeutics, procurement officers must evaluate not only the bulk price but also the technical consistency and safety protocols of the supplier. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier partner in this sector, offering rigorous quality control and scalable production capabilities for high-volume clients.
This compound is highly valued in organic synthesis due to the reactivity of the chloromethyl group, which facilitates nucleophilic substitution reactions. However, its sensitivity to hydrolysis necessitates specialized handling and packaging solutions to maintain integrity during global transit. Understanding the technical specifications and market dynamics is essential for buyers seeking long-term supply agreements.
Distinguishing CAS 874-86-2 from Benzoyl Variants
A common point of confusion in procurement involves distinguishing between benzyl and benzoyl chloride derivatives. While both are acylating or alkylating agents, their chemical behavior differs significantly. The target molecule, often referred to synonymously as 4-(Chloromethyl)benzonitrile or p-Cyanobenzyl chloride, features a chloromethyl group attached to the aromatic ring. This structure is distinct from benzoyl variants which contain a carbonyl chloride group. This structural difference dictates the synthesis route and the subsequent application in medicinal chemistry.
For process chemists, the stability of the nitrile group alongside the reactive chloride is paramount. The material is classified as moisture-sensitive and corrosive, requiring storage under dry inert gas conditions to prevent degradation into the corresponding alcohol or acid. Specifications typically mandate a melting point range between 68°C and 70°C, with a minimum assay of 98%. Buyers must request a comprehensive Certificate of Analysis (COA) that details impurities, particularly residual solvents and heavy metals, to ensure compliance with regulatory standards for pharmaceutical use.
When sourcing high-purity 4-Cyanobenzyl Chloride, buyers should verify that the manufacturer employs rigorous purification processes, such as recrystallization or vacuum distillation, to remove isomeric impurities that could affect downstream reaction yields.
Wholesale Pricing Tiers for Bulk Orders
The bulk price of 4-Cyanobenzyl Chloride is influenced by several factors, including raw material costs for p-tolunitrile, chlorination agents, and energy consumption during manufacturing. Large-scale procurement typically unlocks significant cost advantages compared to laboratory-scale quantities. Industrial buyers should expect tiered pricing structures based on annual volume commitments.
Key factors affecting commercial terms include:
- Purity Grades: Technical grade versus pharmaceutical grade (GMP compliant) will dictate price points. Higher industrial purity often commands a premium due to additional processing steps.
- Packaging: Standard export packaging involves 25kg fiber drums with inner polyethylene liners to ensure moisture protection. Custom packaging options may incur additional costs.
- Lead Time: Spot availability versus made-to-order production impacts pricing. Established relationships with a global manufacturer can secure priority production slots.
Transparency in pricing is a hallmark of professional B2B transactions. Suppliers should provide clear breakdowns of FOB costs, excluding hidden fees related to hazardous material handling. Given the chemical's classification as a corrosive solid (UN3261), logistics costs are a significant component of the landed price. Buyers are advised to negotiate Incoterms that clarify responsibility for hazardous cargo insurance and customs clearance.
Logistics and Global Manufacturer Capabilities
Exporting reactive chemical building blocks requires adherence to strict international safety regulations. As a corrosive solid, 4-Cyanobenzyl Chloride must be transported in compliance with DOT and IMDG codes. A capable supplier will manage all documentation, including Safety Data Sheets (SDS), hazardous goods declarations, and non-dangerous goods certifications where applicable for specific transport modes.
NINGBO INNO PHARMCHEM CO.,LTD. leverages extensive experience in hazardous chemical logistics to ensure timely delivery to ports worldwide. The manufacturing process is designed to minimize environmental impact while maximizing yield, aligning with modern sustainability goals in the fine chemicals industry. Consistency in batch-to-bquality is maintained through strict quality assurance protocols, ensuring that every shipment meets the specified physical and chemical parameters.
The following table outlines the typical technical specifications expected for premium grades of this intermediate:
| Parameter | Specification | Test Method |
|---|---|---|
| Chemical Name | 4-(Chloromethyl)benzenecarbonitrile | GC-MS |
| CAS Number | 874-86-2 | N/A |
| Appearance | White to Off-White Crystalline Solid | Visual |
| Purity (GC Area %) | ≥ 98.0% | Gas Chromatography |
| Melting Point | 68°C - 70°C | DSC / Capillary |
| Moisture Content | ≤ 0.5% | Karl Fischer |
| UN Number | UN3261 | Transport Regulation |
Safety and Handling Protocols
Due to its reactivity, this compound poses specific hazards that must be managed during handling. It is classified under Hazard Category H314 and H318, indicating it causes severe skin burns and eye damage. Personnel must utilize appropriate Personal Protective Equipment (PPE), including chemical-resistant gloves, safety goggles, and protective clothing. Storage areas should be cool, dry, and well-ventilated, strictly segregated from incompatible materials such as strong oxidizing agents, bases, and amines.
In the event of a spill, neutralization procedures should be followed immediately to prevent hydrolysis and the release of hazardous fumes. Waste disposal must comply with local environmental regulations, ensuring that no residue enters water systems. By partnering with a supplier that prioritizes safety and regulatory compliance, pharmaceutical companies can mitigate risk and ensure uninterrupted production schedules.
Ultimately, the selection of a supply partner for chemical building blocks like 4-(chloromethyl)benzenecarbonitrile should be based on a holistic assessment of technical capability, safety record, and commercial flexibility. With the right manufacturer, buyers can secure a stable supply of high-quality intermediates essential for advancing drug development pipelines.