2-Formylphenylboronic Acid Bulk Price Global Manufacturer
- High Purity Standards: Consistent assay ranges exceeding 98% with verified melting points between 120°C and 122°C.
- Scalable Production: Robust manufacturing process ensuring stable supply for kilogram to ton-scale requirements.
- Commercial Transparency: Competitive bulk price models with full documentation including COA and SDS.
In the landscape of modern organic synthesis, few building blocks offer the versatility of boronic acid derivatives. Specifically, 2-Formylbenzeneboronic acid (CAS: 40138-16-7) stands as a critical intermediate for pharmaceutical development and advanced material science. As industries demand tighter quality controls and more predictable supply chains, partnering with a dedicated global manufacturer becomes essential for maintaining production schedules. NINGBO INNO PHARMCHEM CO.,LTD. has established itself as a premier source for this compound, delivering technical excellence alongside commercial reliability.
This chemical entity is characterized by the presence of both an aldehyde group and a boronic acid moiety on adjacent positions of the benzene ring. This ortho-substitution pattern introduces unique reactivity profiles, making it invaluable for Suzuki-Miyaura cross-coupling reactions and the formation of complex heterocyclic systems. However, the proximity of these functional groups can lead to intramolecular cyclization, forming benzoxaboroles under certain conditions. Therefore, maintaining industrial purity requires sophisticated crystallization techniques and strict moisture control during packaging.
Technical Specifications and Quality Control
For procurement officers and lead chemists, verifying physical constants is the first step in vendor qualification. Our production batches adhere to rigorous specifications that match or exceed international pharmacopeia standards. The following table outlines the critical quality attributes expected for high-grade material suitable for drug discovery and process chemistry.
| Parameter | Specification |
|---|---|
| CAS Number | 40138-16-7 |
| Chemical Name | 2-Formylphenylboronic acid (also known as o-formylphenylboronic acid) |
| Molecular Formula | C7H7BO3 |
| Formula Weight | 149.94 g/mol |
| Assay (Purity) | ≥ 98.0% (HPLC/GC) |
| Melting Point | 120.0°C to 122.0°C |
| Appearance | Orange-Pink to Yellow Crystalline Powder |
| Infrared Spectrum | Conforms to Reference Standard |
Consistency in these parameters is vital. Variations in melting point or color can indicate impurities such as unreacted starting materials or oxidation byproducts. Our quality assurance team performs batch-specific testing to ensure every shipment meets these thresholds. Clients receive a comprehensive COA (Certificate of Analysis) with each order, detailing the specific lot number, test results, and expiration date. This documentation is crucial for regulatory filings and internal quality audits.
Synthesis Route and Manufacturing Process
Understanding the synthesis route provides insight into the cost structure and potential impurities of the final product. The manufacturing process typically involves the lithiation of protected bromobenzaldehyde followed by quenching with a borate ester, or alternatively, the direct borylation of appropriate precursors using palladium catalysis. Each method has distinct advantages regarding yield and scalability.
At an industrial scale, the challenge lies in preventing the dehydration of the boronic acid to its anhydride or the aforementioned cyclization to the benzoxaborole form. Advanced purification protocols, including controlled recrystallization from specific solvent systems, are employed to isolate the free boronic acid form. This attention to detail ensures that the Benzaldehyde-2-boronic Acid supplied retains its reactivity for downstream applications. By optimizing these reaction conditions, we maximize yields while minimizing waste, contributing to a more sustainable manufacturing process.
Commercial Availability and Bulk Pricing
For large-scale operations, securing a stable supply is often more critical than the unit cost alone. Market fluctuations can impact the availability of raw materials, leading to lead time extensions. As a committed partner, NINGBO INNO PHARMCHEM CO.,LTD. maintains strategic inventory levels to mitigate these risks. We offer flexible contract pricing models tailored to organizational buyers, allowing for budget predictability over fiscal quarters.
When sourcing high-purity 2-Formylphenylboronic acid, buyers should evaluate the total cost of ownership, which includes purity guarantees, packaging integrity, and logistical support. Our bulk price structures are designed to be competitive for metric ton quantities while maintaining the high margins required for rigorous quality control. Volume discounts are available for committed annual usage, ensuring that R&D centers and production facilities can scale without interruption.
Applications in Pharmaceutical and Material Science
The utility of this compound extends across multiple high-value sectors. In drug development, it serves as a key building block for synthesizing kinase inhibitors and other targeted therapies. Its ability to form stable complexes with biomolecules enhances its value in structure-activity relationship (SAR) studies. Furthermore, in material science, the compound is utilized in the creation of functional polymers and sensors due to its unique electronic properties.
Environmental chemistry applications also leverage this boronic acid derivative for the detection and removal of specific pollutants. The versatility of the molecule means that demand remains robust across diverse industries. Whether used for bioconjugation processes or organic synthesis, the reliability of the source material directly impacts the success of the final application.
Safety, Handling, and Regulatory Compliance
Safety is paramount in the handling of chemical intermediates. This product carries a GHS Signal Word of "Warning" and requires appropriate personal protective equipment during handling. Hazard statements indicate potential respiratory, eye, and skin irritation. Our packaging utilizes robust glass or high-density polyethylene containers sealed under inert atmosphere when necessary to prevent degradation during transit.
We provide full regulatory support, including Safety Data Sheets (SDS) and Certificates of Origin (COO). These documents confirm the synthetic nature of the product and ensure compliance with international trade regulations. For customers requiring specific testing protocols or custom packaging, our technical support team is available to collaborate on solutions that meet specific operational needs.
Conclusion
Selecting the right supplier for critical intermediates like 2-Formylphenylboronic acid is a strategic decision that impacts production efficiency and product quality. By combining advanced synthesis capabilities with a customer-centric commercial approach, NINGBO INNO PHARMCHEM CO.,LTD. delivers value beyond simple transaction. We invite procurement managers and chief scientists to request samples and review our latest batch specifications. Partner with a manufacturer that understands the chemistry and the commerce of fine chemical supply.