3-Bromo-4-Chloropyridine Bulk Price Global Manufacturer 2026
- High Purity Supply: Consistent availability of CAS 36953-42-1 with ≥98% GC purity for complex pharmaceutical synthesis.
- Competitive Bulk Pricing: Significant cost reductions for metric ton quantities compared to laboratory-scale reagent pricing.
- Global Logistics: Specialized cold-chain shipping protocols to maintain stability of this low-melting halogenated compound.
In the landscape of modern pharmaceutical synthesis, 3-Bromo-4-chloropyridine (CAS: 36953-42-1) stands out as a critical building block. As a versatile Halogenated pyridine, this compound serves as a pivotal Organic intermediate for the development of kinase inhibitors and agrochemical agents. For procurement managers and process chemists planning for the 2026 fiscal year, understanding the interplay between industrial purity, synthesis scalability, and volume-based pricing is essential. NINGBO INNO PHARMCHEM CO.,LTD. positions itself as a premier partner in this supply chain, offering technical grade materials that meet rigorous international standards.
Technical Specifications and Physical Properties
When sourcing this Pyridine derivative, precise knowledge of its physical constants is required to ensure proper handling and storage. The compound typically presents as light yellow needles or a clear colorless to yellow liquid after melting, depending on ambient temperature. Given its low melting point, logistics must account for potential phase changes during transit. The following table outlines the key technical specifications required for quality control verification.
| Property | Specification |
|---|---|
| CAS Number | 36953-42-1 |
| Molecular Formula | C5H3BrClN |
| Molecular Weight | 192.44 g/mol |
| Purity (GC) | ≥ 98.0% |
| Melting Point | 17.5 - 18.5 °C |
| Boiling Point | 115 °C (at 20 Torr) |
| Density | 1.19 g/cm³ |
| Storage Conditions | Inert atmosphere, -20°C freezer |
Maintaining Industrial purity above 98% is non-negotiable for downstream coupling reactions. Impurities, particularly isomeric bromochloropyridines, can significantly hinder catalytic efficiency in cross-coupling steps. Therefore, every batch supplied by NINGBO INNO PHARMCHEM CO.,LTD. is accompanied by a comprehensive COA (Certificate of Analysis) detailing HPLC/GC profiles and residual solvent data.
Synthesis Routes and Quality Assurance
The production of high-quality 3-Bromo-4-chloropyridine requires precise control over halogenation selectivity. Industrial synthesis often involves the selective bromination of 4-chloropyridine precursors or chlorination of 3-bromopyridine derivatives. The challenge lies in preventing poly-halogenation and ensuring the correct positional substitution. Process chemists evaluating suppliers should scrutinize the technical documentation regarding the Manufacturing process to verify that impurity profiles are managed effectively.
Superior synthesis routes minimize the formation of regioisomers, which are difficult to separate via standard distillation due to similar boiling points. Advanced crystallization techniques are often employed to achieve the required 98%+ purity. For large-scale applications, consistency between batches is as critical as the initial purity. Robust quality assurance protocols ensure that the Chemical reagent performance remains stable across multiple production runs, reducing the risk of failed batches in your final API synthesis.
Volume-Based Pricing Tiers for Bulk Orders
The market for 3-Brom-4-chlor-pyridin exhibits significant price elasticity based on order volume. Laboratory-scale purchases (grams to kilograms) often command premium pricing due to packaging and handling costs. Data from 2026 market trends indicates that small-scale reagent prices can exceed $100 per 100 grams. However, industrial procurement operates on a fundamentally different economic model.
For bulk orders exceeding 100 kilograms, the Bulk price per kilogram drops substantially. Manufacturers offering metric ton capabilities can provide cost efficiencies that reduce the overall cost of goods sold (COGS) for the final pharmaceutical product. Pricing tiers generally follow this structure:
- Sample Scale (1g - 100g): Premium pricing for R&D verification.
- Pilot Scale (1kg - 25kg): Moderate pricing for process development.
- Production Scale (100kg+): Competitive industrial pricing with negotiated contracts.
Engaging directly with a Global manufacturer allows buyers to bypass intermediary markups. Direct procurement ensures that price negotiations reflect raw material costs and production capacity rather than distribution margins. For 2026 planning, securing fixed-price contracts for annual volumes is recommended to mitigate market volatility.
Global Supply Chain and Logistics Capabilities
Logistics for 3-Bromo-4-chloropyridine require specialized attention due to its chemical stability and safety profile. Classified under GHS07 with warning statements regarding irritation and acute toxicity, proper labeling and documentation are mandatory for international shipping. The compound should be stored under an inert atmosphere and kept frozen below -20°C to prevent degradation or polymerization over time.
Effective supply chain management ensures that the product arrives in optimal condition. This includes using insulated containers with dry ice or gel packs for temperature-sensitive shipments. Furthermore, compliance with regulations such as REACH and TSCA is essential for importing into European and North American markets. A reliable supplier manages all export documentation, including safety data sheets (SDS) and customs declarations, to prevent delays at port.
Requesting Custom Quotes for Large Scale Production
To obtain accurate pricing for large-scale requirements, buyers should provide detailed specifications regarding purity thresholds and packaging preferences. Custom synthesis options may be available for clients requiring specific isotopic labeling or alternative salt forms. When requesting a quote, include your target annual volume and delivery schedule to facilitate the best possible terms.
Partnering with an established entity like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to technical support alongside commercial supply. Their team can assist with scale-up challenges and provide data on reaction yields using their specific batch materials. For long-term projects, establishing a master supply agreement guarantees priority production scheduling and price stability throughout the contract period.
Conclusion
Securing a reliable source of 3-Bromo-4-chloropyridine is a strategic decision for any pharmaceutical manufacturing operation. By prioritizing Industrial purity, verifying synthesis capabilities, and leveraging volume-based pricing, organizations can optimize their supply chain for 2026 and beyond. With robust logistics and a commitment to quality, NINGBO INNO PHARMCHEM CO.,LTD. remains a trusted partner for global chemical procurement.