Industrial Synthesis and Supply of 3-Dimethylamino-1-propanol (CAS 3179-63-3)
- Technical Grade: High purity organic building block suitable for pharmaceutical and agrochemical synthesis.
- Manufacturing: Optimized catalytic hydrogenation processes ensuring consistent industrial purity.
- Procurement: Reliable bulk supply with comprehensive COA and technical support from a global manufacturer.
Overview of 3-Dimethylaminopropanol in Chemical Synthesis
3-Dimethylamino-1-propanol, frequently referenced in technical literature as 3-(Dimethylamino)Propan-1-Ol, is a critical aliphatic amine alcohol used extensively in fine chemical manufacturing. With the CAS number 3179-63-3, this compound serves as a versatile intermediate for constructing complex molecular architectures. Its dual functionality, containing both a hydroxyl group and a tertiary amine, allows for diverse derivatization reactions essential in medicinal chemistry and polymer science.
As a leading global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. specializes in the production of this compound with stringent quality controls. The demand for this reagent has grown due to its utility in creating quaternary ammonium compounds, corrosion inhibitors, and pharmaceutical active ingredients. Understanding the precise synthesis route and physical characteristics is vital for process chemists aiming to integrate this material into large-scale production lines.
Technical Analysis of the Manufacturing Process
The industrial production of this amino alcohol typically involves catalytic amination or hydrogenation pathways. Technical data indicates that high-pressure autoclave systems are employed to manage the reaction kinetics effectively. A common manufacturing process involves the reaction of dimethylamine with suitable precursors such as acrolein or propylene derivatives, followed by catalytic hydrogenation.
Process parameters often utilize Raney-type catalysts, such as Raney cobalt, under controlled hydrogen pressure. For instance, reaction conditions may involve temperatures around 80°C and hydrogen pressures exceeding 60 bar to ensure full conversion of intermediates. The selectivity of the reaction is paramount; while side products like dimethylaminopropanal may form, optimized processes focus on maximizing the yield of the desired alcohol. Maintaining industrial purity requires precise distillation cuts to separate the product from water, ammonia, and unreacted amines.
Quality assurance protocols dictate that the final product must meet specific gas chromatography standards. Residual catalysts and heavy metals are removed through filtration and ion-exchange processes. This level of refinement ensures that the chemical reagent is suitable for sensitive downstream applications where trace impurities could compromise reaction yields or product safety.
Physical and Chemical Properties
For process engineers and procurement specialists, accurate physical data is essential for handling, storage, and reactor design. The following table outlines the key specifications for 1-Dimethylamino-3-propanol based on standard industrial grades.
| Property | Specification |
| Chemical Name | 3-Dimethylamino-1-propanol |
| CAS Number | 3179-63-3 |
| Molecular Formula | C5H13NO |
| Molecular Weight | 103.16 g/mol |
| Appearance | Clear colorless to yellow liquid |
| Boiling Point | 163-164 °C |
| Density | 0.872 g/mL at 25 °C |
| Refractive Index | n20/D 1.436 |
| Flash Point | 97 °F |
| pH Value | 11.3 (10g/l, H2O, 20℃) |
| Water Solubility | Miscible |
| Storage Conditions | Flammables area, Air Sensitive |
The compound exhibits a basic pH due to the tertiary amine group, which necessitates compatibility checks with storage materials. It is stable under normal conditions but is incompatible with strong oxidizing agents. The flash point indicates flammability risks that must be managed according to standard hazard codes (Xi, C). Proper ventilation and grounding are required during transfer operations to mitigate static discharge risks.
Applications as an Organic Building Block
This amino alcohol functions as a robust organic building block across multiple industries. In the pharmaceutical sector, it is utilized in the synthesis of muscle relaxants and various active pharmaceutical ingredients (APIs). The hydroxyl group allows for esterification or etherification, while the amine moiety can be quaternized to form cationic surfactants.
In agrochemicals, derivatives of this compound are used to enhance the solubility and efficacy of herbicide formulations. Additionally, the dyestuff industry employs this reagent to modify solubility profiles of colorants. The versatility of the molecule makes it a staple in R&D laboratories focusing on new material science and medicinal chemistry.
Procurement and Quality Assurance
Sourcing this material requires a partner capable of delivering consistent quality at scale. Buyers should prioritize suppliers who provide comprehensive documentation, including a Certificate of Analysis (COA) for every batch. When sourcing high-purity 3-Dimethylamino-1-propanol, buyers should verify the supplier's capacity for bulk production and their adherence to international safety standards.
NINGBO INNO PHARMCHEM CO.,LTD. offers competitive bulk price structures tailored to long-term contracts. Our commitment to quality assurance ensures that every drum meets the specified refractive index and purity profiles. We provide dedicated technical support to assist clients with integration into their specific synthesis workflows. Whether for pilot plant trials or full-scale commercial production, reliable supply chains are critical to maintaining operational continuity.
Conclusion
3-Dimethylamino-1-propanol remains a vital component in the modern chemical industry. Its unique combination of physical properties and reactivity makes it indispensable for creating high-value intermediates. By partnering with an experienced manufacturer, companies can secure the material quality and supply stability needed for innovation. For detailed specifications and procurement inquiries, professional consultation with our technical sales team is recommended to align product grades with specific application requirements.