3-Bromoisonicotinic Acid Bulk Price Factory Supply 2026
- Market Outlook: 2026 forecasts indicate stabilized bulk pricing for high-purity pyridine derivatives due to optimized synthesis routes.
- Technical Specs: CAS 13959-02-9, MW 202.01 g/mol, typically supplied at >98% industrial purity for scalable reactions.
- Procurement: Factory direct supply chains reduce lead times and ensure consistent COA verification for global shipments.
3-Bromoisonicotinic Acid (CAS: 13959-02-9) represents a critical organic synthesis intermediate within the pharmaceutical and agrochemical sectors. As a heterocyclic compound featuring both a carboxyl group and a bromine substituent on the pyridine ring, it serves as a versatile chemical building block for cross-coupling reactions. The molecular formula C6H4BrNO2 and molecular weight of 202.01 g/mol define its stoichiometric properties, which are essential for process chemists scaling reactions from milligram to kilogram levels. In the context of 2026 procurement strategies, understanding the interplay between industrial purity and bulk price is paramount for maintaining cost-effective production lines.
This compound is typically observed as a white to off-white crystalline powder. Its solubility profile is characterized by low water solubility (approximately 0.5 g/L) but high solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and ethanol. These physical properties dictate the crystallization and purification protocols used during manufacturing. For procurement officers and technical directors, securing a reliable supply chain is as critical as the chemical specifications themselves. When sourcing high-purity 3-Bromoisonicotinic Acid, buyers should prioritize manufacturers who can provide comprehensive Certificate of Analysis (COA) documentation and batch traceability.
Global Market Analysis for 3-Bromoisonicotinic Acid Bulk Procurement
The global demand for pyridine derivatives continues to rise, driven by the development of novel kinase inhibitors and functional materials. 3-Bromoisonicotinic Acid, also known systematically as 3-Bromopyridine-4-carboxylic acid, is particularly valued for its ability to undergo Suzuki, Buchwald-Hartwig, and Heck coupling reactions. The bromine atom acts as a robust leaving group, facilitating the construction of complex biaryl structures essential in modern drug discovery.
Market intelligence for 2026 suggests a shift towards consolidated sourcing. Rather than purchasing small quantities from multiple distributors, large-scale manufacturers are opting for single-source factory supply agreements. This strategy mitigates the risk of batch-to-batch variability, which can significantly impact reaction yields in downstream processes. A global manufacturer with established quality control systems can maintain purity levels above 98%, minimizing the need for costly recrystallization steps upon receipt.
Furthermore, the synthesis route employed by the supplier influences the impurity profile. Traditional bromination methods may introduce regioisomers or poly-brominated byproducts. Advanced catalytic processes improve selectivity, thereby enhancing the overall value proposition of the bulk material. Companies like NINGBO INNO PHARMCHEM CO.,LTD. focus on optimizing these synthesis routes to ensure that the final product meets stringent pharmacopeial standards required for clinical trial material production.
Tiered Pricing Structures for Industrial Organic Intermediate Orders
Pricing for fine chemicals is rarely linear. For 3-Bromoisonicotinic Acid, the unit cost decreases significantly as order volume increases from gram-scale research quantities to metric tonne production batches. Small-scale pricing often reflects the overhead of packaging and quality assurance for low volumes, whereas bulk contracts leverage economies of scale in raw material procurement and reactor utilization.
Below is a representative table outlining the technical specifications and typical packaging options available for industrial procurement. Note that specific pricing is subject to market fluctuations and raw material availability.
| Specification | Detail |
|---|---|
| Product Name | 3-Bromoisonicotinic Acid |
| CAS Number | 13959-02-9 |
| Molecular Formula | C6H4BrNO2 |
| Molecular Weight | 202.01 g/mol |
| Purity (HPLC) | >98.0% (Industrial Grade) |
| Appearance | White to Off-White Crystalline Powder |
| Standard Packaging | 25kg Fiber Drums or Custom Bulk Bags |
| Storage Conditions | Cool, Dry, Well-Ventilated Area (RT) |
Procurement contracts often include clauses for volume rebates. For instance, committing to a quarterly supply schedule can lock in favorable rates, protecting against volatility in bromine and pyridine feedstock costs. It is also essential to consider the total cost of ownership, which includes shipping, import duties, and waste disposal costs associated with lower purity materials. High-purity inputs reduce downstream waste treatment burdens, offering indirect cost savings that complement the direct bulk price advantages.
Logistics and Lead Times for Factory Direct Supply Chains
Efficient logistics are the backbone of reliable chemical manufacturing. For hazardous or sensitive intermediates like 3-Bromoisonicotinic Acid, proper handling during transit is crucial to prevent degradation or contamination. The compound should be stored in a dry environment with humidity below 60% to prevent caking or hydrolysis. While stable at room temperature, protection from direct sunlight is recommended to maintain chemical integrity over long storage periods.
Factory direct supply chains minimize the number of handovers between the production site and the end user. This reduction in touchpoints lowers the risk of labeling errors and physical damage to containers. Standard lead times for bulk orders typically range from 2 to 4 weeks, depending on current production schedules and inventory levels. Expedited options may be available for urgent research needs, though these often incur premium logistics fees.
Safety data sheets (SDS) and transport classifications must be adhered to strictly. While the compound itself is generally stable, it may cause skin and eye irritation, requiring appropriate personal protective equipment (PPE) during handling. NINGBO INNO PHARMCHEM CO.,LTD. ensures that all shipments are accompanied by full regulatory documentation, facilitating smooth customs clearance across international borders. By integrating robust quality assurance with streamlined logistics, buyers can secure a steady flow of critical intermediates necessary for sustaining innovation in medicinal chemistry and materials science.