1-Chloro-4-Isothiocyanatobenzene Bulk Price Global Manufacturer 2026
- Market Stability: Forecasted pricing remains stable for 2026 due to optimized thiophosgene synthesis routes.
- Purity Standards: Industrial grade availability exceeds 99% assay with comprehensive COA documentation.
- Supply Capacity: Bulk procurement supported by monthly production capabilities suitable for large-scale pharmaceutical synthesis.
In the landscape of fine chemical procurement, securing a reliable supply chain for critical intermediates is paramount for maintaining production schedules in pharmaceutical and agrochemical manufacturing. 1-Chloro-4-Isothiocyanatobenzene (CAS: 2131-55-7) stands as a pivotal chemical intermediate used extensively in the construction of complex heterocyclic systems. As we approach 2026, the bulk price dynamics for this compound are influenced by raw material availability, energy costs, and logistical efficiency. NINGBO INNO PHARMCHEM CO.,LTD. positions itself as a premier global manufacturer dedicated to providing consistent quality and competitive commercial terms for international buyers.
This aromatic isothiocyanate serves as a versatile organic building block, facilitating nucleophilic substitutions that are essential in drug discovery and material science. Understanding the technical specifications and market variables is crucial for procurement managers aiming to optimize costs without compromising on industrial purity.
Global Market Pricing Trends for CAS 2131-55-7
The pricing structure for p-Chlorophenyl isothiocyanate is determined by several macroeconomic and microeconomic factors. In the 2026 forecast, stability is expected due to mature production methodologies. However, fluctuations in the cost of precursors, such as p-chloroaniline and thiophosgene, can impact the final FOB price. Buyers should anticipate that volume commitments significantly reduce the per-kilogram cost.
Market analysis indicates that suppliers offering integrated production lines—where precursors are synthesized in-house—can maintain more competitive pricing structures. This vertical integration mitigates the risk of supply chain disruptions. For large-scale projects, negotiating long-term contracts locks in rates, protecting against seasonal volatility in chemical logistics. Procurement strategies should focus on total cost of ownership, including packaging integrity and lead times, rather than solely on the headline unit price.
Technical Specifications and Synthesis Routes
achieving a high assay is critical for downstream reactions. Impurities in isothiocyanates can lead to side reactions, reducing the yield of the final active pharmaceutical ingredient (API). The standard industrial synthesis involves the reaction of p-chloroaniline with thiophosgene in an inert solvent such as dichloromethane. This process requires precise temperature control, typically between 0-5°C, to prevent the formation of urea byproducts.
Below are the key technical parameters expected for premium grade material:
| Property | Specification |
|---|---|
| Chemical Name | 1-Chloro-4-Isothiocyanatobenzene |
| CAS Number | 2131-55-7 |
| Molecular Formula | C7H4ClNS |
| Molecular Weight | 169.63 g/mol |
| Purity (GC/HPLC) | ≥ 99.0% |
| Appearance | Light yellow crystalline mass |
| Boiling Point | 135-136°C (at 24 torr) |
| Melting Point | 43-45°C |
Alternative synthesis route methods exist, such as using phosphorus pentasulfide with p-chlorobenzamide, but the thiophosgene method remains the industry standard for achieving the highest purity levels efficiently. Quality control protocols must include rigorous testing for residual solvents and heavy metals. When sourcing high-purity 1-Chloro-4-Isothiocyanatobenzene, buyers should request detailed Certificates of Analysis (COA) that verify the absence of isomeric impurities which could affect reaction kinetics.
Volume Discounts and Flexible Terms for Bulk Orders
For industrial clients, the ability to scale procurement is essential. NINGBO INNO PHARMCHEM CO.,LTD. offers flexible packaging solutions ranging from laboratory-scale bottles to drum quantities suitable for pilot plants and full-scale production. Bulk orders typically qualify for significant volume discounts, reflecting the reduced handling and packaging costs associated with larger shipments.
Lead times are a critical component of the procurement value proposition. Standard inventory items can often be dispatched within 3 to 7 days, while custom synthesis or large-volume campaigns may require scheduled production slots. Payment terms are structured to accommodate international trade standards, ensuring security for both the manufacturer and the buyer. Logistics partners are vetted to handle hazardous materials compliant with UN 2206 regulations, ensuring safe transport across global borders.
Requesting Customized Quotes and Logistics Estimates
Obtaining an accurate quote requires specific details regarding destination, required purity grades, and annual consumption volumes. Prospective partners should engage directly with the sales technical team to discuss specific application requirements. Whether the compound is intended for pesticide formulation or pharmaceutical intermediate synthesis, custom specifications can often be accommodated.
Documentation support is comprehensive, including Safety Data Sheets (SDS), regulatory compliance statements, and stability data. Proper storage is vital to maintain product integrity; the material should be kept in a cool, dry, well-ventilated area away from oxidizing agents and amines. Containers must remain tightly sealed to prevent moisture ingress, which can degrade the isothiocyanate group.
Safety and Handling Protocols
Handling this compound requires strict adherence to safety guidelines due to its classification as a corrosive and irritant substance. Personal protective equipment (PPE), including chemical-resistant gloves and eye protection, is mandatory during handling. In the event of a spill, absorbent materials should be used, and the area ventilated immediately. Disposal must comply with local environmental regulations to prevent ecological impact.
In summary, the market for CAS 2131-55-7 in 2026 favors buyers who establish strong relationships with capable manufacturers. By prioritizing industrial purity and reliable logistics, companies can secure a competitive advantage in their respective downstream markets. Partnering with a dedicated supplier ensures access to technical support and consistent supply, mitigating the risks associated with chemical procurement.