Industrial Purity 2-Chloro-5-Nitrobenzotrifluoride COA and Technical Specifications
- Verified Quality: Consistent 98% minimum purity with full GC assay verification.
- Technical Data: Comprehensive physical properties including boiling point, density, and refractive index.
- Global Supply: Reliable bulk procurement directly from NINGBO INNO PHARMCHEM CO.,LTD.
In the realm of advanced organic synthesis, the reliability of raw materials dictates the success of downstream pharmaceutical and agrochemical production. 2-Chloro-5-nitrobenzotrifluoride (CAS: 777-37-7) serves as a critical fluorinated intermediate for constructing complex aromatic systems. For process chemists and procurement managers, understanding the nuances of industrial purity and Certificate of Analysis (COA) validation is paramount. This document outlines the technical specifications, quality assurance protocols, and commercial considerations for sourcing this essential chemical.
Physical and Chemical Properties
Accurate physical data is essential for process design, particularly regarding storage conditions and reaction parameters. The material typically presents as a liquid at ambient temperatures, with a melting point near 22°C. This phase behavior necessitates controlled storage environments to prevent solidification during transport in cooler climates. The following table details the standard specifications expected from a tier-one global manufacturer.
| Property | Specification |
|---|---|
| Chemical Name | 2-Chloro-5-nitrobenzotrifluoride |
| CAS Registry Number | 777-37-7 |
| Molecular Formula | C7H3ClF3NO2 |
| Formula Weight | 225.55 g/mol |
| Purity (GC Area %) | ≥ 98.0% |
| Boiling Point | 232°C |
| Density | 1.527 - 1.547 g/mL at 25°C |
| Refractive Index | 1.508 |
| Flash Point | 98°C |
| Storage Conditions | Ambient / Room Temperature |
GC Assay Verification Methods and Standards
The cornerstone of quality control for this organic building block is Gas Chromatography (GC) analysis. Standard industry practice requires a PurCert standard for GC to ensure accurate quantification of the main peak versus impurities. High-performance liquid chromatography (HPLC) may also be utilized, but GC remains the preferred method for volatile aromatic intermediates. A robust COA will detail the column type, temperature gradient, and detector settings used to achieve the reported purity.
Impurities often arise from the chlorination or nitration steps during the manufacturing process. Common contaminants include isomeric chloro-nitro derivatives or residual starting materials. A purity level of 98% is generally acceptable for most industrial applications, but specific synthetic routes may require further distillation or recrystallization. Buyers should request chromatograms alongside the COA to verify peak resolution and ensure no co-eluting impurities compromise the reaction yield.
Moisture Content Specifications and Limits
Water content is a critical parameter for reactions involving moisture-sensitive reagents, such as organometallics or strong reducing agents. While standard technical grade material may not always specify Karl Fischer titration results, high-purity batches should maintain moisture levels below 0.5%. Excessive moisture can lead to hydrolysis of the trifluoromethyl group under extreme conditions or interfere with catalyst activity. Procurement specifications should explicitly state moisture limits if the downstream process is water-sensitive.
Certificate of Analysis Review Process
Reviewing a COA requires more than a glance at the purity percentage. Procurement teams must verify that the batch number on the COA matches the container label. Key safety data, including hazard statements and precautionary codes, must align with current GHS standards. For instance, this material is classified under Hazard Class 6.1 and requires careful handling due to toxicity upon inhalation or skin contact. The COA should also confirm compliance with regulatory frameworks such as TSCA or EINECS, ensuring smooth customs clearance during international shipping.
When sourcing high-purity 2-Chloro-5-nitrobenzotrifluoride, buyers should prioritize suppliers who provide batch-specific documentation rather than generic typical values. This transparency reduces risk in scale-up phases and ensures reproducibility across production runs.
Safety and Handling Protocols
Safety data indicates that this compound is harmful if inhaled and causes serious eye irritation. Appropriate personal protective equipment (PPE), including chemical safety goggles and impermeable gloves, is mandatory during handling. The material is combustible, with a flash point of 98°C, requiring storage away from open flames and oxidizing agents. Ventilation systems must be adequate to prevent vapor accumulation, adhering to precautionary statements such as P261 (avoid breathing dust/fume/gas/mist/vapours/spray) and P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes).
Commercial Considerations and Bulk Procurement
For large-scale production, bulk price stability and supply chain reliability are as crucial as chemical specifications. Market fluctuations in fluorinated raw materials can impact costing models. Partnering with a dedicated manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures consistent access to material that meets rigorous technical standards. Direct factory supply eliminates intermediary markups and reduces lead times.
Logistics for hazardous chemicals require specialized packaging and documentation. Drum sizes typically range from 25kg to 250kg, depending on the supplier's capacity and the buyer's requirements. It is essential to confirm that the supplier has experience exporting hazardous Class 6.1 materials to the destination country to avoid customs delays. Long-term supply agreements often provide better pricing tiers and guarantee allocation during periods of high market demand.
Conclusion
2-Chloro-5-nitrobenzotrifluoride is a vital component in the synthesis of modern pharmaceuticals and agrochemicals. Ensuring the integrity of this intermediate through rigorous COA review, understanding physical properties, and adhering to safety protocols is essential for operational success. By focusing on industrial purity and partnering with established suppliers, companies can mitigate risk and optimize their synthetic routes. For technical inquiries or volume quotations, direct engagement with the manufacturer is recommended to secure the best terms and quality assurance.