6-Fluoronicotinic Acid Bulk Price Global Manufacturer Analysis
- Technical Specification: CAS 403-45-2, Molecular Weight 141.10 g/mol, Purity >98%.
- Commercial Advantage: Significant cost reductions available for kilogram and ton-scale procurement.
- Supply Chain: Reliable global logistics with full regulatory documentation and COA support.
In the realm of medicinal chemistry and pharmaceutical process development, fluorinated heterocycles serve as critical building blocks for active pharmaceutical ingredients (APIs). Among these, 6-Fluoronicotinic Acid (CAS: 403-45-2) stands out as a versatile pyridine derivative used extensively in the synthesis of kinase inhibitors and PET tracers. For procurement managers and process chemists, understanding the bulk price dynamics and technical specifications is essential for optimizing production costs without compromising industrial purity.
This compound, also systematically known as 6-fluoropyridine-3-carboxylic acid, features a carboxylic acid group at the 3-position and a fluorine atom at the 6-position of the pyridine ring. This specific substitution pattern facilitates nucleophilic aromatic substitution reactions, making it a preferred scaffold for drug discovery. When evaluating suppliers, it is crucial to distinguish between retail-grade reagents and materials produced via a scalable synthesis route designed for industrial application.
Volume-Based Pricing Tiers vs Retail Gram Costs
The cost structure for fluorinated building blocks varies significantly based on order volume. Retail suppliers often charge premium rates for gram-scale quantities, which is suitable for initial screening but economically unviable for process scale-up. A true global manufacturer offers tiered pricing models that reflect the efficiencies of large-batch production. Procuring material in kilogram or multi-kilogram lots typically reduces the cost per gram by over 60% compared to catalog prices.
The following table outlines typical specification standards and estimated pricing tiers for industrial procurement. Note that exact figures depend on market fluctuations and specific purity requirements.
| Parameter | Specification | Commercial Impact |
|---|---|---|
| CAS Number | 403-45-2 | Standard identifier for regulatory compliance |
| Chemical Formula | C6H4FNO2 | Confirms molecular structure integrity |
| Purity (HPLC) | >98.0% | Reduces downstream purification costs |
| Melting Point | 144 – 148°C | Key quality control metric for identity |
| Packaging | 1kg to 25kg Drums | Optimized for safe international shipping |
For organizations requiring 2-Fluoro-5-pyridinecarboxylic Acid for clinical trial material production, negotiating a long-term supply agreement ensures price stability. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. focus on consistent batch-to-batch reproducibility, which is critical when filing regulatory dossiers. Variability in impurity profiles can lead to failed validation batches, making the reliability of the supplier as important as the unit price.
Global Supply Chain and Logistics Capabilities
Shipping fluorinated organic compounds requires adherence to strict international hazardous materials regulations. A competent supplier must provide comprehensive documentation, including Safety Data Sheets (SDS), Certificates of Analysis (COA), and method validation reports. Logistics capabilities extend beyond simple shipping; they encompass customs clearance expertise and temperature-controlled transport if necessary to maintain stability.
Lead times are another critical factor in supply chain management. While retail vendors may ship from local warehouses quickly, their stock is often limited. In contrast, a dedicated manufacturing partner operates on a made-to-order or large-batch inventory model. This ensures that large volumes are available without the risk of stockouts that can halt production lines. Fast delivery protocols are established through partnerships with major freight forwarders, ensuring that materials reach R&D centers in Europe, North America, and Asia efficiently.
Quality assurance processes are integral to the supply chain. Upon receipt, procurement teams should verify the material against key physical constants. The appearance should be a white to off-white powder, and the melting point must fall within the 144 – 148°C range. Deviations often indicate solvent retention or isomeric impurities, which can affect reaction yields in subsequent synthesis steps.
Requesting Custom Quotes for Industrial Scale
Securing the best value requires direct engagement with the manufacturing source rather than intermediaries. When sourcing high-purity 6-Fluoronicotinic Acid, buyers should request quotes that specify the intended scale of use. This allows the supplier to recommend the most cost-effective packaging and purity grade. For example, some applications may tolerate 97% purity, while others require >99% for direct use in sensitive catalytic cycles.
Technical support is a vital component of the procurement process. A reliable partner provides access to process chemists who can discuss potential impurities, storage conditions, and compatibility with specific reaction solvents. This level of technical support minimizes the risk of project delays caused by material failures. Furthermore, custom synthesis options are often available for derivatives or analogs that are not part of the standard catalog, allowing for greater flexibility in drug design.
In summary, optimizing the procurement of fluorinated building blocks involves balancing technical specifications with commercial terms. By partnering with a established entity like NINGBO INNO PHARMCHEM CO.,LTD., organizations gain access to robust supply chains, competitive pricing structures, and the technical expertise required for successful scale-up. Ensuring a steady supply of high-quality intermediates is foundational to accelerating the journey from laboratory discovery to commercial manufacturing.
Key Takeaways for Procurement
- Verify Purity: Always request an HPLC chromatogram and NMR spectrum with the COA to confirm industrial purity levels.
- Scale Economics: Leverage volume-based pricing tiers to reduce overall project costs significantly.
- Documentation: Ensure all regulatory documents are provided upfront to facilitate smooth customs clearance.