Pharmaceutical Grade 2-Chloroadenosine CAS 146-77-0: GMP Supplier & Bulk Supply
- For R&D: Optimized synthesis routes ensuring minimal impurity profiles and consistent nucleoside analog performance.
- For Procurement: Factory-direct bulk pricing with verified COA documentation and stable tonnage supply chains.
- For Executives: Full regulatory compliance (GMP/REACH) and scalable manufacturing capacity for commercial viability.
In the development of targeted antiviral and anticancer therapies, the reliability of raw material sourcing is paramount. 2-Chloroadenosine (CAS 146-77-0) serves as a critical building block in medicinal chemistry, particularly for projects involving adenosine receptor modulation and apoptosis pathways. As a premier GMP supplier, NINGBO INNO PHARMCHEM CO.,LTD. delivers process-scale purity and documentation integrity required for global regulatory submissions.
Technical Synthesis and Impurity Control
For process chemists and R&D teams, the consistency of the synthesis route directly impacts downstream reaction yields and final drug substance quality. Our manufacturing process utilizes advanced chlorination techniques on adenosine precursors to maximize conversion efficiency while minimizing side reactions. The resulting product, often referenced in literature as 6-Amino-2-chloropurine riboside, undergoes rigorous purification to remove residual solvents and process-related impurities.
Maintaining industrial purity is essential when this nucleoside analog is employed in sensitive biochemical assays or cell signaling studies. Variations in hydration states or isomeric purity can alter solubility profiles and reactivity. Our production batches are characterized using HPLC and NMR to ensure batch-to-batch consistency, supporting research in neuronal signaling, immune response modulation, and metabolic enzyme inhibition.
Quality Assurance and Regulatory Compliance
Executive decision-makers require assurance that supply chain partners meet international regulatory standards. NINGBO INNO PHARMCHEM CO.,LTD. operates under strict quality management systems aligned with current Good Manufacturing Practices. This ensures that every shipment is accompanied by a comprehensive Certificate of Analysis (COA), Safety Data Sheet (SDS), and Certificate of Origin (COO).
Compliance extends beyond basic documentation. Our facilities are audited for environmental safety and chemical handling protocols, adhering to guidelines such as REACH and TSCA where applicable. This reduces regulatory risk for downstream manufacturers integrating 2-Chloroadenosine into clinical trial materials or commercial formulations.
Technical Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 146-77-0 | Verified |
| Molecular Formula | C10H12ClN5O4 | Calculated |
| Molecular Weight | 301.69 g/mol | MS |
| Purity (HPLC) | ≥ 98.0% | Area Normalization |
| Appearance | White to Off-White Solid | Visual |
| Loss on Drying | ≤ 0.5% | Karl Fischer / LOD |
| Heavy Metals | ≤ 10 ppm | ICP-MS |
Procurement and Supply Chain Stability
Procurement officers prioritize supply continuity and cost efficiency without compromising quality standards. When sourcing high-purity pharmaceutical grade intermediates, buyers should verify the manufacturer's capacity to handle tonnage quantities. Our facility is equipped for scalable production, ensuring that pilot-scale requirements can be seamlessly transitioned to commercial volumes without re-qualification delays.
We offer flexible packaging options suitable for both laboratory research and large-scale manufacturing. Our logistics network ensures secure shipping with appropriate temperature controls and hazard labeling, mitigating risks associated with international transport of chemical intermediates.
Conclusion
Selecting the right partner for 2-Chloroadenosine supply involves balancing technical specifications with commercial reliability. By choosing a dedicated manufacturer with robust quality controls, pharmaceutical companies can accelerate their development timelines and ensure product safety.
To proceed with your procurement process, please contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote.