4-Bromophenol Cas 106-41-2 Coa Quality Assurance
- [Chemical Integrity]: Verified via GC-HPLC orthogonal methods to ensure >99% assay and minimal dibromo impurities.
- [Procurement Logic]: Factory-direct tonnage availability eliminates supply chain bottlenecks for scale-up.
- [Regulatory Status]: Full export documentation including REACH/TSCA alignment and batch-specific COA generation.
In the realm of fine chemical synthesis, maintaining strict control over intermediate quality is paramount for downstream success. 4-Bromophenol (CAS 106-41-2) serves as a critical building block for pharmaceuticals, agrochemicals, and advanced polymer materials. As a premier Global Manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. specializes in delivering this key intermediate with uncompromising Quality Assurance protocols. Whether utilized in Stille coupling reactions or as a precursor for analgesics, the consistency of the raw material dictates the efficiency of the final process.
Procurement teams and process chemists require more than just a commodity chemical; they need a partner who understands the nuances of Industrial Purity. This article details the technical specifications, testing protocols, and compliance frameworks necessary to secure a reliable supply chain for p-Bromohydroxybenzene derivatives.
Understanding Certificate of Analysis Data
A robust Certificate of Analysis (COA) is the cornerstone of vendor qualification. For high-value intermediates, the COA must transcend basic identity confirmation and provide a detailed impurity profile. When evaluating suppliers, procurement officers should scrutinize the reported assay methods. Reliable manufacturers utilize orthogonal testing, combining Gas Chromatography (GC) with High-Performance Liquid Chromatography (HPLC) to validate purity levels.
Key parameters on a comprehensive COA for this substrate include:
- Assay Purity: Typically required at >99.0% for pharmaceutical grade applications.
- Melting Point: A sharp melting range indicates high crystallinity and low solvent retention.
- Water Content: Karl Fischer titration results ensure compatibility with moisture-sensitive reactions.
- Residual Solvents: Compliance with ICH Q3C guidelines is essential for drug substance manufacturing.
At NINGBO INNO PHARMCHEM CO.,LTD., every batch is accompanied by a searchable, lot-specific COA. This transparency allows R&D teams to validate material suitability before integration into complex synthesis routes, reducing the risk of failed batches due to variable raw material quality.
Batch Consistency and GC Testing Protocols
For process chemists, batch-to-batch consistency is critical for maintaining reaction yields and minimizing purification burdens. The Manufacturing Process for 4-Hydroxybromobenzene involves the controlled bromination of phenol. Without precise temperature control and stoichiometric management, side reactions can lead to the formation of 2,4-dibromophenol or unreacted phenol, both of which are difficult to separate downstream.
Our quality control laboratories employ rigorous GC testing protocols to monitor these specific impurities. By maintaining strict control over the electrophilic aromatic substitution conditions, we ensure that the regioselectivity favors the para-isomer. This level of control is vital when sourcing high-purity 4-Bromo-Phenol for scale production. Consistent impurity profiles mean that reaction kinetics remain predictable, allowing engineering teams to optimize residence times and catalyst loading with confidence.
Furthermore, stability testing confirms that the product remains within specification during storage under ambient conditions (>5 °C). This ensures that the material received at the manufacturing site performs identically to the samples tested during the initial tech transfer phase.
Regulatory Compliance Documentation for Export
For executives and supply chain managers, regulatory compliance is as critical as chemical specification. Global distribution requires a suite of documentation to clear customs and meet local environmental safety standards. Beyond the standard Safety Data Sheets (SDS) and Product Specifications (PS), international buyers often require Certificates of Origin (COO) to verify the synthetic source and manage tariff classifications.
Compliance frameworks such as REACH (Europe) and TSCA (USA) dictate how chemical substances are registered and handled. Our production facilities are audited to ensure adherence to these regulations, facilitating smoother import processes for our clients. Additionally, understanding the Bulk Price structure involves factoring in these compliance costs; working with a compliant manufacturer avoids costly delays at ports or regulatory penalties.
We support our partners with full documentation packages, including:
- Non-GMO Statements: Confirming synthetic origin for cosmetic and food-adjacent applications.
- Heavy Metal Analysis: Ensuring levels are below ppm thresholds for sensitive applications.
- Transport Classification: Proper UN coding for safe logistics handling.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 106-41-2 | N/A |
| Chemical Name | 4-Bromophenol | N/A |
| Molecular Formula | C6H5BrO | N/A |
| Purity (GC Area %) | > 99.0% | GC-FID |
| Melting Point | 63.0 - 65.0 °C | DSC / Capillary |
| Appearance | White to Off-White Crystalline Powder | Visual |
| Water Content | < 0.5% | Karl Fischer |
Securing a reliable source for critical intermediates requires a partner dedicated to technical excellence and supply chain stability. To ensure your production lines remain operational with verified materials, we invite you to contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote.