Ethyl (S)-(-)-4-Chloro-3-Hydroxybutyrate Bulk Price 2026: Market Analysis & Sourcing Guide
- [Kinetic Yield]: Optimized biocatalytic routes ensure >99% ee for downstream statin synthesis.
- [Procurement Volume]: Tiered pricing structures available for kilogram to metric ton scales.
- [Compliance Framework]: Full documentation packages including COA, SDS, and REACH alignment.
The global demand for chiral intermediates continues to escalate as pharmaceutical pipelines expand into metabolic disorder treatments. Specifically, the Ethyl (S)-(-)-4-Chloro-3-Hydroxybutyrate bulk price 2026 forecasts indicate a stabilization in costs for large-scale procurement, driven by improved manufacturing efficiencies. This compound, often recognized as a critical Atorvastatin Side Chain precursor, requires rigorous quality control to ensure downstream synthesis success. For procurement officers and technical directors, understanding the divergence between research-grade pricing and industrial-scale contracts is essential for budgeting and supply chain security.
Technical Synthesis and Impurity Profiles for R&D
For process chemists, the viability of this chiral building block depends heavily on the synthetic route employed. Traditional chemical reduction methods often struggle with enantiomeric excess, whereas modern biocatalytic processes have set a new benchmark for consistency. When sourcing high-purity optical purity is a critical parameter that directly impacts the yield of the final active pharmaceutical ingredient (API).
The preferred manufacturing process involves the enzymatic reduction of ethyl 4-chloro-3-oxobutanoate. This route typically achieves reaction yields exceeding 90% with an enantiomeric excess (ee) of >99%. Key impurities to monitor during quality control include the (R)-enantiomer, unreacted keto-ester, and chlorohydrin byproducts. Advanced chromatographic methods are required to verify that the Ethyl (3S)-4-chloro-3-hydroxybutanoate content meets stringent pharmacopeial standards before it enters the production line.
Procurement Strategy and Bulk Pricing Tiers
Market intelligence suggests that while gram-scale pricing remains high due to packaging and handling overheads, the bulk price for kilogram and tonnage quantities offers significant economies of scale. Research-grade suppliers often list small quantities at premium rates with lead times of 6 to 8 days. However, industrial buyers should negotiate blanket purchase orders to secure volume discounts and guaranteed allocation.
Supply chain stability is paramount. Buyers should prioritize vendors who can demonstrate industrial purity across multiple batches. Consistency in water content and chloride levels prevents downstream reaction failures. Furthermore, verifying the Certificate of Analysis (COA) against internal standards is a non-negotiable step in the vendor qualification process. Direct manufacturer engagement eliminates intermediary markups and ensures traceability from raw material to finished goods.
Executive Overview: Compliance and Scalability
For executive leadership, the strategic sourcing of Ethyl (S)-4-Chloro-3-Hydroxybutyrate involves assessing regulatory risk and production scalability. A reliable supply partner must adhere to international safety standards, providing comprehensive Safety Data Sheets (SDS) and Certificates of Origin (COO). Compliance with regulations such as REACH and TSCA is critical for uninterrupted global logistics.
As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. offers these technical advantages and bulk supply capabilities to meet the evolving needs of the pharmaceutical industry. Scalability is ensured through dedicated production lines capable of ramping up from pilot batches to commercial tonnage without compromising quality parameters. This capacity allows partners to align their raw material inventory with long-term product launch schedules.
Quality Specifications and Technical Parameters
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 86728-85-0 | N/A |
| Chemical Name | Ethyl (S)-(-)-4-Chloro-3-Hydroxybutyrate | N/A |
| Purity (GC) | > 98.0% | Gas Chromatography |
| Optical Purity (ee) | > 99.0% | Chiral HPLC |
| Water Content | < 0.5% | Karl Fischer |
| Appearance | Colorless to Pale Yellow Liquid | Visual |
Conclusion and Request for Quotation
Securing a stable supply of this key intermediate is vital for maintaining production timelines in statin manufacturing. The market outlook for 2026 favors buyers who establish long-term contracts with verified manufacturers capable of delivering consistent quality and competitive pricing. To ensure your supply chain remains robust, we invite you to contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote.
Partnering with NINGBO INNO PHARMCHEM CO.,LTD. ensures access to high-grade intermediates supported by rigorous quality assurance and global logistics expertise.