Ethyl (S)-4-Chloro-3-Hydroxybutyrate
- CAS No.86728-85-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity chiral intermediate essential for Atorvastatin synthesis. Available in bulk with strict quality control and comprehensive COA.
Request Bulk PricingProduct Technical Details
Product Overview
Ethyl (S)-4-Chloro-3-Hydroxybutyrate is a highly specialized chiral intermediate essential for the modern pharmaceutical industry. As a critical building block, this compound plays a fundamental role in the asymmetric synthesis of various statin medications, most notably Atorvastatin. Our manufacturing process prioritizes stereochemical integrity, ensuring that the S-enantiomer is preserved with high optical purity throughout production. This level of precision is vital for downstream reactions where chirality dictates the biological activity and safety profile of the final active pharmaceutical ingredient.
We produce this chemical using advanced organic synthesis techniques under strict quality management systems. The result is a reliable supply of high-purity material suitable for large-scale commercial drug manufacturing. Our facility adheres to international safety and environmental standards, providing partners with a sustainable and compliant sourcing option for their global supply chains. Consistency in batch-to-bquality is guaranteed through rigorous process controls.
Technical Specifications
| CAS Number | 86728-85-0 |
|---|---|
| Molecular Formula | C6H11ClO3 |
| Molecular Weight | 166.603 g/mol |
| Appearance | Colorless to light yellow liquid |
| Assay (Purity) | ≥96.0% |
| Specific Rotation | -19° to -24° |
| Boiling Point | 93-95 °C (5 mmHg) |
| Density | 1.19 g/cm³ |
| Flash Point | 109 °C |
| Moisture Content | ≤0.5% |
Industrial Applications
The primary application of Ethyl (S)-4-Chloro-3-Hydroxybutyrate lies in the production of HMG-CoA reductase inhibitors. It serves as a key side-chain precursor for Atorvastatin and Atorvastatin calcium, which are widely prescribed for managing cholesterol levels and reducing cardiovascular risk. The high optical purity of our intermediate ensures efficient coupling reactions, minimizing waste and maximizing yield in the final API synthesis. Beyond statins, this compound may also serve as a versatile synthon in the development of other chiral pharmaceuticals requiring a specific hydroxybutyrate motif for biological function.
Quality Assurance and Packaging
Quality control is paramount in our operation. Every batch undergoes rigorous testing using high-performance liquid chromatography (HPLC) and polarimetry to verify assay and specific rotation values. We provide a comprehensive Certificate of Analysis (COA) with every shipment to confirm compliance with agreed specifications. Our team is dedicated to supporting clients with technical data required for regulatory filings.
- Strict monitoring of chiral purity to prevent racemization during storage.
- Low moisture content ensured through specialized drying and distillation processes.
- Stable packaging designed to prevent degradation during international transit.
- Customizable packaging solutions to meet specific logistical requirements.
Standard packaging involves 25 kg drums, though we offer flexible solutions tailored to customer logistics requirements. Storage recommendations include keeping the material in a cool, ventilated area away from direct sunlight and moisture to maintain stability over time. Proper handling procedures should be followed to ensure safety in the laboratory or production environment.
