Comprehensive COA and Specifications for 3-[1-(Dimethylamino)Ethyl]Phenol ≥99% Purity
- [Molecular Integrity]: Validated stereochemistry and impurity profiles optimized for high-yield Rivastigmine synthesis.
- [Supply Chain Resilience]: Factory-direct tonnage availability with verified batch-to-batch consistency and stable logistics.
- [Regulatory Alignment]: Full documentation packages including COA, SDS, and compliance with international safety standards.
In the competitive landscape of pharmaceutical intermediate manufacturing, securing raw materials with verified industrial purity is paramount for downstream drug production. 3-[1-(Dimethylamino)ethyl]phenol (CAS: 105601-04-5) serves as a critical building block, particularly in the synthesis of acetylcholinesterase inhibitors. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. ensures that every batch meets stringent quality benchmarks required by R&D teams and procurement officers alike. This technical overview details the specifications, synthesis considerations, and supply chain advantages associated with this key intermediate.
Technical Specifications and Quality Parameters
For process chemists and quality control managers, understanding the physical and chemical properties of the intermediate is essential for process validation. The following table outlines the critical quality attributes expected from a commercial-grade supply chain. Deviations in melting point or purity can significantly impact reaction yields in subsequent steps.
| Parameter | Specification Standard | Typical Result |
|---|---|---|
| Chemical Name | 3-[1-(Dimethylamino)ethyl]phenol | Conforms |
| CAS Registry Number | 105601-04-5 | 105601-04-5 |
| Molecular Formula | C10H15NO | C10H15NO |
| Molecular Weight | 165.23 g/mol | 165.23 g/mol |
| Purity (HPLC/GC) | ≥ 99.0% | ≥ 99.5% |
| Melting Point | 87-89°C | 88°C |
| Appearance | White to Light Yellow Powder/Crystal | Off-white Crystal |
| Storage Conditions | Sealed in dry, 2-8°C | Compliant |
Synthesis Routes and Impurity Profiling for R&D
From a synthetic chemistry perspective, the production of 3-[(1S)-1-(Dimethylamino)ethyl]phenol and its racemic counterpart requires precise control over alkylation and reduction steps. The efficiency of the synthesis route directly influences the impurity profile, particularly regarding regioisomers and unreacted starting materials. High-quality intermediates minimize the burden on downstream purification, thereby reducing overall production costs.
When evaluating potential suppliers, technical teams should scrutinize the Certificate of Analysis for specific impurity limits. Our manufacturing process employs advanced chromatographic purification to ensure that related substances remain well below ICH thresholds. This level of industrial purity is critical when scaling from pilot plant to commercial production, as even minor variances can affect the crystallization behavior of the final API.
Procurement Advantages and Bulk Supply Stability
For procurement specialists, supply chain reliability is as crucial as chemical specifications. Market data indicates significant price volatility for small-pack reagents, but established partnerships with a dedicated manufacturer stabilize bulk price structures for tonnage quantities. Sourcing directly eliminates the markup associated with third-party traders and ensures traceability back to the original production batch.
When sourcing high-purity 3-[1-(Dimethylamino)ethyl]phenol, buyers should prioritize vendors who offer comprehensive documentation. NINGBO INNO PHARMCHEM CO.,LTD. provides factory-direct advantages, including customized packaging solutions and expedited shipping protocols. This ensures that material specifications, their certification, and all handling conditions are communicated clearly at the time of material handover.
Key Procurement Considerations
- Batch Verification: Every shipment is accompanied by a batch-specific COA verifying purity and physical constants.
- Inventory Security: Strategic stockpiling ensures availability even during raw material shortages.
- Logistics Compliance: Adherence to international shipping regulations for hazardous materials (H301, H318).
Regulatory Compliance and Executive Overview
Executive decision-makers must weigh commercial viability against regulatory risk. Utilizing intermediates like Phenol 3-[(1S)-1-(dimethylamino)ethyl]- requires assurance that the supplier operates under robust quality management systems. Compliance with environmental and safety standards mitigates liability and ensures uninterrupted production schedules.
Our facility invests in high-quality packaging materials and uses international logistics partners to service customers globally. While all possible precautions are taken to deliver the required product(s), our policy ensures that any material not meeting requirements is addressed on a priority basis. This commitment to quality assurance supports long-term commercial viability and protects brand reputation in the pharmaceutical sector.
Conclusion and Next Steps
Securing a reliable supply of CAS 105601-04-5 is a strategic decision that impacts both R&D efficiency and production costs. By partnering with a verified manufacturer, organizations gain access to superior technical support, stable pricing, and guaranteed quality. To proceed with vendor qualification or request samples, please contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote.