Intermediates

3-[1-(Dimethylamino)ethyl]phenol

CAS No.105601-04-5
GradeIndustrial / Pharmaceutical
Availability● In Stock

High-purity 3-[1-(Dimethylamino)ethyl]phenol (CAS 105601-04-5), a key chiral intermediate in the synthesis of Rivastigmine and its tartrate salt for neurological therapeutics.

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Product Technical Details

Product Overview

3-[1-(Dimethylamino)ethyl]phenol is a high-value chiral aromatic amine alcohol widely employed as a critical building block in advanced pharmaceutical synthesis. This compound serves as an essential intermediate in the production of Rivastigmine (CAS 123441-03-2) and Rivastigmine tartrate (CAS 129101-54-8), active pharmaceutical ingredients used in the management of neurodegenerative conditions. Our product is manufactured under stringent quality control protocols to ensure exceptional chemical integrity and stereochemical consistency.

Specifications

Molecular Formula	C₁₀H₁₅NO
Molecular Weight	165.23 g/mol
Density	1.021 g/cm³
Boiling Point	241.3°C at 760 mmHg
Flash Point	97.2°C
Refractive Index	1.539
Appearance	White to off-white crystalline powder
Assay (Purity)	≥99%
Water Content (K.F.)	≤0.5%
Single Impurity	≤0.5%
Total Impurities	≤0.5%
Residue on Ignition	≤0.2%
Heavy Metals	≤0.002%

Industrial Applications

This compound is exclusively utilized as a synthetic intermediate in regulated pharmaceutical manufacturing. Its primary application lies in the enantioselective synthesis of acetylcholinesterase inhibitors targeting cognitive disorders. Due to its structural complexity and functional versatility, it is not intended for direct use in consumer formulations but rather as a controlled input in multi-step API production sequences.

Enables efficient construction of the carbamate core in Rivastigmine derivatives
Compatible with standard amine and phenol protection/deprotection strategies
Supplied with full regulatory documentation including Certificate of Analysis (COA)

Stored in sealed, light-resistant containers under cool, dry conditions to maintain stability and prevent moisture uptake or oxidative degradation.