2-(2,3-Difluorophenyl)Acetic Acid Industrial Purity Coa Specifications
- [Synthetic Pathway]: Optimized lithiation and reduction sequence delivering >77% total recovery with minimized isomeric impurities.
- [Logistics Stability]: Secure tonnage quantities available with verified REACH/TSCA compliance for uninterrupted manufacturing.
- [Analytical Verification]: Batch-specific HPLC data and melting point validation (117-119°C) provided with every shipment.
2,3-Difluorophenylacetic acid (CAS: 145689-41-4) serves as a critical fluorinated building block in the development of novel pharmaceutical intermediates and liquid crystal materials. As demand scales for difluorinated aromatic structures, procurement teams and process chemists require more than just catalog availability; they need guaranteed supply chain resilience and transparent technical data. NINGBO INNO PHARMCHEM CO.,LTD. operates as a premier global manufacturer, delivering this key intermediate with the process-scale purity required for commercial synthesis.
Optimized Synthesis Route and Reaction Yields
For R&D departments evaluating scale-up feasibility, the robustness of the synthesis route is paramount. Traditional methods involving Grignard reagents or nucleophilic substitution often suffer from low yields (approximately 30-44%) and significant isomeric byproduct formation, complicating downstream purification. Our manufacturing process utilizes an optimized organolithium pathway that overcomes these historical defects.
The production begins with the low-temperature lithiation of 1,2-difluorobenzene, followed by acylation with oxalic acid esters to form the glyoxylic acid ester intermediate. Subsequent alkaline reduction using hydrazine hydrate yields the target 2,3-Difluorobenzeneacetic acid. This method ensures mild reaction conditions and clean post-processing. By controlling crystallization parameters using methanol-water or hexane-ethyl acetate systems, we achieve batch-to-batch consistency with HPLC content reaching 99.6% in purified forms. This technical advantage reduces solvent waste and improves overall cost efficiency for large-scale organic synthesis campaigns.
Technical Specifications and Quality Assurance
Procurement managers require precise data to validate incoming materials against internal standards. Reliance on generic lab-grade specifications can introduce risk during technology transfer. When sourcing high-purity industrial purity materials, buyers should demand comprehensive Certificates of Analysis (COA) that detail impurity profiles beyond simple assay percentages.
The following table outlines the standard quality parameters maintained at our facility. These specifications are designed to meet the rigorous demands of pharmaceutical and agrochemical production lines.
| Parameter | Specification Standard | Test Method |
|---|---|---|
| CAS Number | 145689-41-4 | N/A |
| Chemical Name | 2-(2,3-Difluorophenyl)acetic acid | N/A |
| Molecular Formula | C8H6F2O2 | N/A |
| Molecular Weight | 172.13 g/mol | N/A |
| Appearance | White to Off-White Crystalline Powder | Visual |
| Melting Point | 117°C to 119°C | DSC / Capillary |
| Assay (HPLC) | > 98.0% (Standard) / > 99.0% (Custom) | Area Normalization |
| Related Impurities | Single Impurity < 0.5% | HPLC |
Every batch shipped from our facility undergoes strict quality assurance protocols. We provide full documentation, including SDS and NMR spectra upon request, ensuring that the Difluorophenyl acetic acid received matches the technical dossier provided during the sampling phase.
Commercial Viability and Bulk Supply
For executives assessing commercial viability, supply chain stability is as critical as chemical performance. Market intelligence indicates that reliance on single-source distributors in specific regions can lead to procurement bottlenecks. As a dedicated factory supply partner, NINGBO INNO PHARMCHEM CO.,LTD. mitigates this risk through vertically integrated production capabilities.
We offer competitive bulk price structures for tonnage quantities, supported by a logistics network capable of handling hazardous materials compliance globally. Our regulatory team ensures adherence to relevant chemical inventory standards, facilitating smoother customs clearance and inventory management. By partnering directly with the manufacturer, clients eliminate intermediary markups and gain direct access to technical support for process optimization.
Secure Your Supply Chain Today
Ensuring consistent access to high-specification intermediates is essential for maintaining production schedules. Do not compromise on material consistency or documentation. Contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote to discuss how we can support your upcoming projects.