Industrial Purity 1,6-Dibromohexane Synthesis Route Guide
For R&D teams and procurement officers sourcing industrial purity 1,6-Dibromohexane, understanding the underlying manufacturing process is critical for formulation compatibility and cost efficiency. This technical brief outlines the precise reaction conditions required for high-yield production of this essential alkylating agent, often referred to as Hexamethylene Bromide. At NINGBO INNO PHARMCHEM CO.,LTD., we prioritize transparency in our synthesis route to ensure every batch meets rigorous analytical standards.
Advanced Synthesis Route and Reaction Mechanism
The production of 1,6-Dibromohexane typically begins with the bromination of 1,6-hexanediol. In a reactor equipped with a reflux condenser and dropping funnel, hexanediol is dissolved with hydrobromic acid at ambient temperature. Concentrated sulfuric acid is introduced slowly while maintaining the temperature at 40°C to control exothermic activity. Following complete addition, the mixture is heated to reflux over 1.5 hours. The organic phase is subsequently washed with water and 5% sodium carbonate to neutralize acidic residues, dried over anhydrous calcium chloride, and purified via vacuum distillation. The target fraction is collected at 143-145°C under 3.9 kPa pressure, ensuring process-scale purity suitable for polymerization and electrochemical studies.
| Parameter | Specification | Analytical Method |
|---|---|---|
| CAS Number | 629-03-8 | N/A |
| Purity (GC) | ≥ 99.0% | Gas Chromatography |
| Boiling Point | 143-145°C / 3.9 kPa | Distillation |
| Water Content | ≤ 0.1% | Karl Fischer |
| Packaging | 250 KG Drum | Visual Inspection |
Supply Chain Stability and Packaging Options
Securing a reliable supply of this chemical reagent requires a partner capable of managing tonnage quantities without compromising quality. Our facility provides comprehensive COA verification for every shipment, ensuring compliance with international regulatory frameworks such as REACH and TSCA. Whether utilized as an organic linker in polymer synthesis or for specialized electrochemical reduction research, consistency is paramount. NINGBO INNO PHARMCHEM CO.,LTD. maintains robust inventory levels to support global manufacturers requiring bulk price stability and just-in-time delivery schedules.
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