Industrial Purity Standards For 4-Bromo-3-Trifluoromethylphenol
The global demand for fluorinated aromatic intermediates continues to surge, driven by complex pharmaceutical pipelines and advanced agrochemical formulations. Procurement executives and R&D leaders prioritize supply chain resilience when sourcing critical building blocks like 4-Bromo-3-(trifluoromethyl)phenol. Consistency in chemical composition is non-negotiable for downstream synthesis efficiency. NINGBO INNO PHARMCHEM CO.,LTD. addresses these market requirements by maintaining rigorous production controls and transparent quality documentation. Understanding the macro-supply context helps buyers mitigate risks associated with raw material volatility and regulatory compliance.
Technical specifications and analytical methods
Ensuring industrial purity requires validated analytical protocols that exceed standard pharmacopoeia expectations. Our quality assurance team utilizes HPLC, GC-MS, and NMR spectroscopy to verify identity and assay values for every lot. The following table outlines the critical physical and chemical properties expected for high-grade material suitable for sensitive coupling reactions.
| Parameter | Specification |
|---|---|
| CAS Number | 320-49-0 |
| Molecular Formula | C7H4BrF3O |
| Molecular Weight | 241.01 g/mol |
| Melting Point | 44-46°C |
| Boiling Point | 61-63 °C (3.5-4.0 Torr) |
| Density | 1.752±0.06 g/cm³ |
| Appearance | Light yellow crystalline powder |
| Solubility | Soluble in Methanol |
Each shipment is accompanied by a comprehensive COA detailing impurity profiles and residual solvent analysis. This level of documentation is essential for regulatory filings and internal quality audits.
Detailed chemical synthesis route and reaction mechanism
The preferred synthesis route for this intermediate involves the controlled bromination of 3-trifluoromethylphenol. In a typical manufacturing process, bromine is added dropwise to a solution of the phenol precursor at room temperature. The reaction mixture is stirred overnight to ensure complete conversion before quenching in water. Subsequent extraction with dichloromethane and washing with sodium bicarbonate solution removes acidic byproducts. The crude product is purified via silica gel column chromatography using a hexane and ethyl acetate mobile phase. This method yields high-purity 2-Bromo-5-hydroxybenzotrifluoride, also known synonymously as 3-Trifluoromethyl-4-bromophenol, with verified structural integrity through spectral data.
Factory-direct bulk pricing advantages and supply chain stability
Procurement strategies must account for long-term cost efficiency without compromising quality. By operating as a direct manufacturer, we eliminate intermediary markups, offering competitive bulk price structures for tonnage orders. Supply chain stability is further reinforced through strategic raw material stocking and multi-stage inventory management. For detailed market forecasts and procurement planning, clients often reference our analysis on 4-Bromo-3-(Trifluoromethyl)Phenol Bulk Price 2026. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to stable lead times and consistent availability, ensuring your production schedules remain uninterrupted regardless of market fluctuations.
Securing a reliable partner for specialized intermediates is a strategic decision that impacts overall project viability. Our dedicated technical support team works closely with chemists and purchasing managers to align product specifications with application needs. We prioritize transparency, safety, and performance in every transaction.
To request a batch-specific COA, SDS, or secure a bulk pricing quote, please contact our technical sales team.