4-Bromo-3-(trifluoromethyl)phenol
- CAS No.320-49-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Bromo-3-(trifluoromethyl)phenol (CAS 320-49-0), a versatile fluorinated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
4-Bromo-3-(trifluoromethyl)phenol is a high-value fluorinated aromatic building block widely employed as a key intermediate in the synthesis of complex organic molecules. With its unique combination of bromo and trifluoromethyl substituents adjacent to a phenolic hydroxyl group, this compound offers exceptional reactivity for cross-coupling reactions, nucleophilic substitutions, and functional group transformations. It serves as a critical precursor in the development of active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials requiring enhanced metabolic stability and lipophilicity.
Specifications
| Molecular Formula | C7H4BrF3O |
|---|---|
| Molecular Weight | 241.005 g/mol |
| CAS Number | 320-49-0 |
| Appearance | Off-white powder |
| Assay | ≥98.0% |
| Melting Point | 44–46°C |
| Boiling Point | 234.9 ± 35.0 °C at 760 mmHg |
| Density | 1.8 ± 0.1 g/cm³ |
| Flash Point | 95.8 ± 25.9 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25°C |
| Refractive Index | 1.505 |
Industrial Applications
This fluorinated phenolic intermediate is primarily utilized in multi-step synthetic routes within the pharmaceutical and agrochemical industries. Its bromine atom enables efficient palladium-catalyzed cross-coupling (e.g., Suzuki, Sonogashira), while the electron-withdrawing trifluoromethyl group modulates electronic properties and enhances bioavailability in target molecules. Common applications include:
- Synthesis of novel kinase inhibitors and anti-inflammatory agents
- Construction of fluorinated heterocyclic scaffolds for drug discovery
- Development of herbicides and fungicides with improved environmental profiles
- Preparation of liquid crystals and advanced polymeric materials
Stored in a cool, well-ventilated area away from oxidizing agents, 4-Bromo-3-(trifluoromethyl)phenol is typically supplied in 25 kg drums or customized packaging to meet global regulatory and logistical requirements.
