Industrial Synthesis of 3-Chloro-1-propanol from 1,3-Propanediol
The global demand for 3-Chloro-1-propanol, also known as Trimethylene Chlorohydrin, continues to rise driven by its critical role in the synthesis of heterocyclic compounds and pharmaceutical intermediates. As supply chains face volatility, securing a reliable source of this key building block is essential for R&D teams and procurement executives. NINGBO INNO PHARMCHEM CO.,LTD. provides a stable supply of this essential chemical, ensuring that production schedules remain uninterrupted. Our commitment to industrial purity and rigorous quality assurance supports large-scale manufacturing processes across the agrochemical and fine chemical sectors.
Technical specifications and analytical methods
Quality control is paramount for process chemists validating inputs for sensitive reactions. Our manufacturing process adheres to strict specifications to guarantee consistency. Below are the standard technical parameters for our factory supply.
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 627-30-5 | N/A |
| Chemical Name | 3-Chloro-1-propanol (Beta-Chloropropanol) | N/A |
| Purity (GC) | ≥ 99.0% | Gas Chromatography |
| Water Content | ≤ 0.5% | Karl Fischer Titration |
| Appearance | Colorless to Pale Yellow Liquid | Visual Inspection |
| Boiling Point | 160-162°C (at 760 mmHg) | Distillation |
Detailed chemical synthesis route and reaction mechanism
The preferred industrial synthesis route for 3-Chloropropanol involves the chlorination of 1,3-Propanediol. This manufacturing process typically utilizes dry hydrogen chloride gas reacted with the diol feedstock. In a continuous operation, 1,3-propanediol is heated to approximately 150-170°C while a rapid stream of dry HCl is introduced. This reaction substitutes one hydroxyl group with a chlorine atom, yielding 3-Chlorpropan-1-ol and water. To achieve high industrial purity, the crude distillate undergoes fractional distillation under reduced pressure. This step separates the target product from unreacted glycol and water, ensuring the final 1-Chloro-3-propanol meets stringent pharma-grade standards. Our technical team optimizes reaction kinetics to minimize byproduct formation, such as di-γ-chloropropyl ether, maximizing yield and efficiency.
Factory-direct bulk pricing advantages and supply chain stability
Procurement managers prioritize cost-efficiency without compromising on quality. By operating as a global manufacturer, we eliminate intermediary markups, offering competitive bulk price structures directly from the factory. Our supply chain is designed for resilience, mitigating risks associated with raw material fluctuations. Whether you require this chemical raw material for pilot-scale trials or full commercial production, we maintain robust inventory levels. chemical raw material availability is monitored continuously to prevent downtime. We provide full documentation, including batch-specific COA and SDS, to facilitate regulatory compliance and quality assurance audits.
Partnering with NINGBO INNO PHARMCHEM CO.,LTD. ensures access to high-performance intermediates backed by technical expertise and logistical reliability. We are dedicated to supporting your long-term production goals with consistent quality and transparent communication.
To request a batch-specific COA, SDS, or secure a bulk pricing quote, please contact our technical sales team.