4-Ethylphenylboronic Acid Bulk Price 2026 Global Manufacturer
- Technical Grade Supply: High-purity CAS 63139-21-9 optimized for Suzuki-Miyaura cross-coupling reactions.
- 2026 Market Outlook: Stable bulk pricing tiers available for metric ton procurement with secure logistics.
- Quality Assurance: Comprehensive COA and MSDS documentation provided for all industrial batches.
In the landscape of modern organic synthesis, organoboron compounds serve as critical intermediates for pharmaceutical and agrochemical development. Specifically, 4-Ethylphenylboronic acid (CAS 63139-21-9) is a high-demand reagent utilized extensively in palladium-catalyzed cross-coupling reactions. As we approach 2026, procurement strategies must shift from small-scale research quantities to industrial-grade supply chains that guarantee consistency, safety, and cost-efficiency. NINGBO INNO PHARMCHEM CO.,LTD. stands at the forefront of this supply chain, delivering verified technical specifications and scalable production capacity to meet global pharmaceutical standards.
Understanding the commercial dynamics of this chemical requires a deep dive into production capabilities, purity benchmarks, and logistical compliance. This analysis provides a technical overview for procurement officers and process chemists seeking reliable sources for (4-ethylphenyl)boronic acid without compromising on reaction yields or safety protocols.
Bulk Pricing Tiers and MOQ Requirements
The bulk price of organoboron intermediates is influenced by raw material availability, purification complexity, and order volume. Unlike research-grade chemicals sold in gram quantities, industrial procurement focuses on kilogram and metric ton scales. For 2026, market projections indicate stable pricing for established manufacturers who control their upstream supply chains. Buyers should expect tiered pricing structures where the unit cost decreases significantly as the Minimum Order Quantity (MOQ) increases from 25kg drums to full container loads.
Several factors drive the cost structure for this commodity. First, the industrial purity level is paramount. Standard commercial grades often offer 95-97% purity, but pharmaceutical applications frequently require 98% or higher to minimize side reactions during coupling. Higher purity necessitates advanced recrystallization or chromatography steps, which impacts the final bulk price. Second, packaging and stabilization are critical. Boronic acids can undergo protodeboronation or form anhydrides upon exposure to moisture. Therefore, industrial packaging must include moisture barriers and inert atmosphere sealing, adding to the logistical cost but ensuring product integrity upon arrival.
Procurement teams should also consider the total cost of ownership, which includes freight, insurance, and customs clearance. Reliable suppliers offer Incoterms such as FOB or CIF that align with the buyer's logistics network. When evaluating quotes, it is essential to verify that the pricing includes comprehensive quality documentation, as cheaper alternatives often lack the rigorous testing required for GMP environments.
Verified Global Manufacturer Credentials
Selecting the right supply partner is as critical as the chemical specification itself. A credible supplier must demonstrate robust capacity, regulatory compliance, and technical expertise. When sourcing high-purity intermediates, buyers should prioritize a global manufacturer with a proven track record in process chemistry. NINGBO INNO PHARMCHEM CO.,LTD. exemplifies this standard, operating facilities designed for large-scale synthesis and strict quality control protocols.
The manufacturing process for 4-Ethylphenylboronic acid typically involves the reaction of 4-ethylphenyl halides with trialkyl borates followed by hydrolysis, or alternatively, direct borylation using diboron reagents. The efficiency of this synthesis route directly correlates to the impurity profile of the final product. Top-tier manufacturers utilize optimized catalytic systems to maximize yield and minimize halogenated impurities, which can poison downstream catalysts. Process chemists should request detailed impurity profiles, including data on residual solvents, heavy metals, and specific isomeric byproducts.
Furthermore, verified manufacturers maintain ISO-certified facilities and adhere to international safety standards. This includes proper handling of combustible solids and adherence to GHS classification guidelines. For CAS 63139-21-9, safety data indicates it is a combustible solid with specific hazard codes (H302, H319). A professional supplier ensures that all batches are tested against these safety parameters before shipment, reducing liability for the purchasing organization.
Requesting Official COA and Samples
Before finalizing a bulk contract, technical due diligence is mandatory. This process begins with the request for a Certificate of Analysis (COA). A valid COA for (4-ethylphenyl)boronic acid must include specific analytical data points such as assay percentage (typically via HPLC or GC), melting point range, water content (Karl Fischer), and residual solvent analysis. Without this documentation, validating the material for production use is impossible.
Sample evaluation is the next critical step. Procurement officers should request pre-shipment samples ranging from 100g to 500g for pilot-scale testing. This allows the R&D team to verify reaction performance, solubility profiles, and stability under process conditions. During this phase, it is advisable to test the material in the intended coupling reaction to confirm that catalytic turnover numbers meet expectations. Any deviation in yield compared to reference standards should be investigated immediately with the supplier.
Logistics and lead time are also part of the sampling protocol. Reliable manufacturers can dispatch samples within 5 to 7 business days, accompanied by safety data sheets (SDS) and transport classification documents. For international shipments, ensuring proper classification under UNSPSC Code 12352103 and adherence to WGK 3 water hazard regulations is essential for smooth customs clearance.
Technical Specifications Overview
The following table outlines the standard technical parameters expected for industrial-grade procurement. Buyers should use this as a checklist when comparing vendor specifications.
| Parameter | Specification |
|---|---|
| Product Name | 4-Ethylphenylboronic Acid |
| CAS Number | 63139-21-9 |
| Molecular Formula | C2H5C6H4B(OH)2 |
| Molecular Weight | 149.98 g/mol |
| Purity (HPLC) | ≥ 98.0% |
| Appearance | White to Off-White Crystalline Powder |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral, Eye Irrit. 2 |
| Packaging Options | 25kg, 50kg, 100kg Drums or Bags |
In conclusion, securing a stable supply of 4-Ethylphenylboronic acid for 2026 requires a partnership with a manufacturer that prioritizes technical excellence and commercial reliability. By focusing on industrial purity, verifying the manufacturing process, and insisting on comprehensive COA documentation, procurement teams can mitigate supply chain risks. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to supporting these industrial needs with scalable solutions and transparent commercial terms.