Global Manufacturers of 4-(Methoxy)-1-Chlorobutane: Technical & Commercial Insights
- NINGBO INNO PHARMCHEM CO.,LTD. delivers 1-Chloro-4-methoxybutane with ≥98% industrial purity via optimized synthesis routes for pharmaceutical intermediates.
- Key LSI identifiers include 4-Methoxybutyl chloride, methyl 4-chlorobutyl ether, and 4-(methoxy)-1-chlorobutane—ensuring precise technical alignment.
- Bulk procurement is supported with full COA documentation, ISO-compliant production, and global logistics under ambient shipping conditions.
As a critical building block in medicinal chemistry, 1-Chloro-4-methoxybutane (CAS 17913-18-7)—also known as 4-(methoxy)-1-chlorobutane, 4-Methoxybutyl chloride, or methyl 4-chlorobutyl ether—is increasingly sought after for its role in alkylation reactions and heterocycle synthesis. With molecular formula C5H11ClO and a molecular weight of 122.59 g/mol, this compound serves as a versatile intermediate in the production of APIs, agrochemicals, and specialty polymers.
Industrial Synthesis Route and Purity Standards
The commercial viability of 4-Chlorobutyl methyl ether hinges on a robust and scalable synthesis route. Leading manufacturers employ nucleophilic substitution between 1,4-butanediol monomethyl ether and thionyl chloride (SOCl2) or hydrogen chloride under controlled conditions. This method ensures high reaction yields (>85%) while minimizing di-ether byproducts and residual acidity.
At NINGBO INNO PHARMCHEM CO.,LTD., the process is further refined through fractional distillation under reduced pressure, yielding a final product with industrial purity consistently ≥98.0% (GC). Every batch undergoes rigorous QC protocols, including NMR, GC-MS, and Karl Fischer titration for water content (<0.1%), with full Certificates of Analysis (COA) provided upon request.
When sourcing high-purity 1-Chloro-4-methoxybutane, buyers should prioritize suppliers with documented impurity profiling—especially for chlorinated residuals and methoxy alcohol precursors—that could compromise downstream reactivity.
Global Manufacturing Capabilities and Compliance
While multiple entities list 1-Chloro-4-methoxybutane in their catalogues, only a select few operate GMP-aligned or ISO 9001-certified facilities capable of multi-hundred-kilogram to metric-ton scale production. Regional differences significantly impact both quality consistency and supply chain resilience.
Manufacturers in Asia—particularly in China’s Zhejiang and Jiangsu provinces—have emerged as dominant players due to vertically integrated infrastructure, cost-efficient raw material access, and stringent environmental compliance. NINGBO INNO PHARMCHEM CO.,LTD. exemplifies this advantage, combining R&D-driven process optimization with export-ready logistics and regulatory documentation (REACH, TSCA, etc.).
In contrast, Western suppliers often position the compound as a research-grade item (≤100g), with limited capacity for bulk orders and significantly higher per-kilogram pricing. This makes them less suitable for commercial-scale API campaigns requiring consistent, long-term supply.
Storage, Stability, and Handling
Although stable under ambient conditions during shipping, 1-Chloro-4-methoxybutane should be stored at 2–8°C in tightly sealed, amber glass or fluoropolymer-lined containers to prevent hydrolysis or oxidation. Its low flash point (~45°C) necessitates standard precautions for flammable organic halides during handling and transfer.
Bulk Procurement Economics and Supply Chain Reliability
For B2B buyers evaluating bulk price competitiveness, total landed cost—not just unit price—must guide vendor selection. Key factors include:
- Minimum order quantity (MOQ) flexibility (e.g., 1 kg vs. 25 kg drums)
- Lead time consistency (typically 2–4 weeks for custom batches)
- Incoterms clarity (FOB Ningbo vs. DDP destination)
- Regulatory support (SDS, COA, customs documentation)
NINGBO INNO PHARMCHEM CO.,LTD. addresses these needs through dedicated account management, real-time inventory visibility, and multimodal shipping options (air, sea, courier), ensuring uninterrupted supply for global pharmaceutical and fine chemical clients.
Comparative Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 17913-18-7 |
| Synonyms | 4-(Methoxy)-1-chlorobutane, Butane 1-chloro-4-methoxy, Ether, 4-chlorobutyl methyl |
| Molecular Formula | C5H11ClO |
| Molecular Weight | 122.59 g/mol |
| Purity (GC) | ≥98.0% |
| Appearance | Colorless to pale yellow liquid |
| Storage Condition | 2–8°C, under inert atmosphere |
| Shipping Condition | Ambient (non-hazardous classification under current IATA/IMDG guidelines) |
In summary, for organizations seeking a reliable, high-capacity global manufacturer of 1-Chloro-4-methoxybutane with proven expertise in pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. stands out through its commitment to synthesis efficiency, analytical transparency, and scalable supply—making it the strategic partner of choice for industrial and R&D applications worldwide.