Bulk Price 2-(2-Hydroxyphenyl)-4H-1,3-Benzoxazin-4-One Global Manufacturer
- Technical Grade: Consistent industrial purity exceeding 98% with full COA documentation.
- Commercial Scale: Volume-based pricing tiers available for kilogram to metric ton procurement.
- Supply Chain: Reliable global manufacturer ensuring secure logistics and timely lead times.
In the landscape of pharmaceutical intermediates, securing a reliable supply chain for complex heterocyclic compounds is critical for maintaining production schedules. 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one, identified by CAS 1218-69-5, represents a high-value scaffold essential for the synthesis of iron chelators and other therapeutic agents. As a premier global manufacturer, understanding the technical specifications and commercial dynamics of this molecule is paramount for procurement officers and process chemists alike.
This compound, often referred to in technical literature as 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one, serves as a pivotal building block. Its molecular formula, C14H9NO3, and molecular weight of 239.23 g/mol require precise handling during scale-up. The demand for this chemical is driven largely by its role as a Deferasirox intermediate, necessitating strict adherence to purity standards to prevent downstream contamination in final drug products.
Technical Specifications and Synthesis Overview
The production of this benzoxazinone derivative typically involves the condensation of salicylic acid derivatives with anthranilic acid counterparts under dehydrating conditions. Achieving high industrial purity requires optimized reaction parameters, including temperature control and solvent selection, to minimize side products such as unreacted starting materials or isomeric impurities.
At NINGBO INNO PHARMCHEM CO.,LTD., the synthesis route is rigorously monitored to ensure batch-to-batch consistency. The final product undergoes extensive purification, often involving recrystallization, to meet the stringent requirements of pharmaceutical-grade applications. When sourcing high-purity 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one, buyers should verify the availability of comprehensive analytical data, including HPLC chromatograms and NMR spectra, to confirm structural integrity.
Key physical properties include a stable crystalline structure that facilitates handling and storage. The compound exhibits solubility profiles compatible with standard organic solvents used in medicinal chemistry, allowing for seamless integration into subsequent coupling reactions. Ensuring the absence of heavy metals and residual solvents is a standard part of the quality control protocol for any reputable supplier.
Volume-Based Pricing Tiers for Kilogram Scale
Procurement strategies for fine chemicals must account for economies of scale. The bulk price of CAS 1218-69-5 fluctuates based on raw material availability, energy costs, and order volume. Manufacturers typically structure pricing into tiers to incentivize larger commitments, which helps stabilize the supply chain for both the producer and the buyer.
| Order Volume | Purity Grade | Packaging | Lead Time |
|---|---|---|---|
| 1 kg - 10 kg | 98%+ (Lab Scale) | Aluminum Foil Bag | 3-5 Days |
| 10 kg - 100 kg | 98%+ (Pilot Scale) | Cardboard Drum | 7-10 Days |
| 100 kg - 1000 kg | 99% (Industrial Scale) | Custom Drumming | 15-20 Days |
| 1000 kg+ | Custom Specification | Bulk Bags / Tank | Negotiated |
The table above illustrates standard market expectations. However, specific contracts may vary based on custom synthesis requirements. For large-scale projects, locking in pricing through long-term agreements is advisable to mitigate market volatility. Custom synthesis options are also available for clients requiring specific impurity profiles or isotopic labeling.
Global Logistics and Lead Time Estimates
Efficient logistics are as crucial as chemical quality. A reliable supply chain ensures that materials arrive within the projected window, preventing production bottlenecks. Shipping terms usually follow Incoterms 2020, with FOB and CIF being the most common for international transactions. Proper packaging is essential to maintain stability during transit, protecting the material from moisture and physical damage.
Lead times are influenced by production scheduling and regulatory documentation. Standard stock items may ship within a week, while made-to-order batches require additional time for synthesis and quality assurance testing. Export documentation, including the Certificate of Analysis (COA) and Certificate of Origin (COO), is prepared concurrently with the shipment to facilitate customs clearance.
Requesting Formal Quotes for Bulk Procurement
To obtain an accurate quotation, buyers should provide detailed specifications regarding purity, packaging, and destination. Engaging directly with a global manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures that technical queries are handled by experts who understand the nuances of the synthesis route and potential scale-up challenges.
Formal requests should include the intended application, required annual volume, and any specific regulatory compliance needs (e.g., REACH, DMF support). This information allows the supplier to tailor the production process and logistics plan to meet the client's exact requirements. Transparent communication regarding quality standards and testing protocols fosters a strong partnership.
In conclusion, securing a stable supply of 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one requires a partner capable of delivering both technical excellence and commercial reliability. By focusing on industrial purity, scalable manufacturing, and robust logistics, procurement teams can ensure uninterrupted production of high-value pharmaceutical intermediates.