Sourcing Ara-G For [18F: High Purity Precursor Supply
9-β-D-Arabinofuranosylguanine Purity Specifications: HPLC Assay ≥99.5%, Isomeric Purity, and NMR Structural Validation
For the synthesis of [18F]F-AraG, a radiolabeled nucleoside analog used for imaging activated T cells, the quality of the cold precursor dictates the radiochemical yield and specific activity of the final tracer. NINGBO INNO PHARMCHEM CO.,LTD. manufactures 9-β-D-Arabinofuranosylguanine (CAS: 38819-10-2) with strict control over impurity profiles that can interfere with fluorination reactions. Our standard HPLC assay confirms purity ≥99.5%, ensuring minimal competition from guanine or arabinose derivatives during the labeling step. Isomeric purity is critical; the presence of the α-anomer reduces effective precursor concentration and can complicate purification. We validate structural integrity via 1H and 13C NMR to confirm the β-configuration at the anomeric center, providing a reliable substrate for your synthesis route.
If you are currently sourcing Ara-G from suppliers facing capacity constraints, our product serves as a seamless drop-in replacement. We maintain identical technical parameters to leading benchmarks while offering enhanced supply chain reliability and cost-efficiency. This allows radiopharmacies and CROs to transition without re-validating their labeling protocols. For detailed specifications on our high-purity Ara-G precursor for radiolabeling, please review our product documentation.
Certificate of Analysis (COA) Compliance: Residual Solvents (ICH Q3C), Heavy Metals, and Endotoxin Limits for Radiopharmaceutical Precursors
Radiopharmaceutical precursors must meet rigorous safety standards to support clinical and preclinical applications. Our Certificate of Analysis (COA) provides comprehensive data on residual solvents, tested against ICH Q3C guidelines to ensure no interference with biological assays or regulatory submissions. Heavy metal content is monitored to prevent catalytic degradation of the nucleoside structure during storage or labeling. For applications requiring low endotoxin levels, we offer batches with validated endotoxin limits, essential for GMP-compliant radiolabeling facilities producing [18F]F-AraG for human use.
Each batch is accompanied by a full COA detailing all tested parameters. We do not provide EU REACH registrations or environmental certifications; our focus remains on delivering chemically precise intermediates with full traceability. Buyers requiring specific impurity profiling or custom synthesis capabilities can request tailored analytical reports. Our technical support team assists in interpreting COA data to ensure compatibility with your specific biochemical reagent requirements and quality management systems.
Physical and Chemical Technical Metrics: Specific Rotation [α]D, Melting Point Range, and Moisture Content Analysis
Physical properties of 9-arabinofuranosylguanine influence handling, dissolution, and stability in labeling cocktails. Specific rotation [α]D confirms optical purity and stereochemical consistency across batches. Moisture content is tightly controlled, as hygroscopic uptake can affect weighing accuracy in micro-scale synthesis modules. Melting point range serves as an indicator of crystalline integrity and absence of amorphous degradation products. Below is a comparison of key technical parameters for our industrial purity grade Ara-G.
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | White to off-white powder | Visual Inspection |
| HPLC Assay | ≥99.5% | HPLC-UV |
| Specific Rotation [α]D | Please refer to the batch-specific COA | Polarimetry |
| Melting Point | Please refer to the batch-specific COA | Capillary Method |
| Loss on Drying | Please refer to the batch-specific COA | Thermogravimetric Analysis |
| Residual Solvents | Complies with ICH Q3C | GC-MS |
| Heavy Metals | Please refer to the batch-specific COA | ICP-MS |
Field Note: During microfluidic [18F] labeling campaigns, we have observed that certain crystalline forms of Ara-G exhibit delayed dissolution kinetics in anhydrous DMSO at 80°C. This can lead to incomplete conversion and lower radiochemical yield. Our manufacturing process controls the crystallization cooling rate to ensure a consistent polymorph that dissolves within 30 seconds under standard labeling conditions, preventing batch-to-batch variability in your synthesis module. This practical optimization reduces cycle time and improves reproducibility for high-throughput production.
Bulk Packaging and Stability Data: Lyophilized Formulation, Nitrogen-Flushed Vials, and Accelerated Degradation Profiles
Stability of 9-beta-D-arabinofuranosylguanine is preserved through specialized packaging designed for sensitive nucleoside analogs. We offer lyophilized formulations to minimize hydrolytic degradation, packaged in nitrogen-flushed vials to prevent oxidative damage. Accelerated degradation profiles demonstrate shelf-life stability under controlled temperature and humidity conditions. For bulk orders, we provide secure packaging with desiccant packs and temperature indicators to ensure product integrity during transit.
Logistics are managed with strict attention to physical protection and environmental control. Shipments are arranged via temperature-controlled courier services to maintain stability. We do not make claims regarding regulatory compliance or environmental certifications; our responsibility ends with delivering the chemical in the specified physical state. Buyers requiring custom packaging configurations or technical support for storage protocols can contact our team for guidance based on empirical stability data.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for Ara-G?
The MOQ varies depending on the grade and packaging format. For research quantities, we offer smaller lots, while bulk pricing applies to larger volumes. Please contact our sales team for specific MOQ details tailored to your requirements.
Can you provide samples for evaluation before placing a bulk order?
Yes, we provide samples for technical evaluation upon request. Samples are subject to availability and may require a signed confidentiality agreement. Contact our technical support team to arrange sample shipment.
What is the typical lead time for delivery?
Lead times depend on stock availability and order volume. Standard lead times are provided upon quotation. For urgent requirements, please discuss expedited shipping options with our logistics team.
Is your Ara-G suitable for GMP radiopharmaceutical production?
We supply Ara-G with full COA documentation and traceability. Suitability for GMP production depends on your facility's validation and quality assessment. We provide all necessary technical data to support your compliance review.
Do you offer custom synthesis or modified specifications?
We have capabilities for custom synthesis and can discuss modified specifications based on your application needs. Please provide detailed requirements to our technical team for feasibility assessment and quotation.
Sourcing and Technical Support
NINGBO INNO PHARMCHEM CO.,LTD. delivers high-purity 9-β-D-Arabinofuranosylguanine with consistent quality, reliable supply, and comprehensive technical documentation. Our focus on crystalline control, impurity management, and stability ensures optimal performance in [18F]F-AraG synthesis. We support radiopharmaceutical developers with responsive technical assistance and flexible commercial terms.
Ready to optimize your supply chain? Reach out to our logistics team today for comprehensive specifications and tonnage availability.