Industrial Purity Specifications for 4,4-Dimethylisoxazolidin-3-One
- Target Assay: Industrial grade specifications typically require ≥99.0% purity for agrochemical synthesis.
- Quality Control: Critical metrics include Loss on Drying, residual solvent analysis, and heavy metal compliance.
- Procurement: Bulk sourcing ensures cost efficiency and consistent supply chain reliability for large-scale production.
In the competitive landscape of agrochemical intermediate manufacturing, the consistency of raw materials dictates the success of the final active ingredient. 4,4-dimethylisoxazolidin-3-one (CAS: 81778-07-6) serves as a critical building block in the synthesis of specific herbicides and pharmaceutical compounds. For process chemists and procurement managers, understanding the technical nuances of industrial purity is essential to maintaining reaction yields and minimizing downstream purification costs.
As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. adheres to rigorous quality standards to ensure that every batch meets the demanding requirements of modern organic synthesis. This article details the technical specifications, quality control metrics, and commercial considerations necessary for sourcing this high-value intermediate.
Technical Specifications and Physical Properties
Accurate data regarding physical properties is vital for process scaling and safety handling. The following table outlines the standard technical parameters for this oxazolidinone derivative. These values are consistent with high-grade commercial production.
| Property | Specification |
| Chemical Name | 4,4-Dimethyl-1,2-oxazolidin-3-one |
| CAS Number | 81778-07-6 |
| Molecular Formula | C5H9NO2 |
| Molecular Weight | 115.13 g/mol |
| Density | 1.039 g/cm³ |
| HS Code | 2934999090 |
| Storage Condition | 2-8°C (Recommended for stability) |
| Hazard Codes | Xi (Irritant) |
The molecular structure features a dimethyl substitution at the 4-position of the isoxazolidinone ring, which influences both its reactivity and stability. Proper storage at controlled temperatures is necessary to prevent degradation, ensuring the material remains viable for long-term inventory.
Manufacturing Process and Synthesis Route
The manufacturing process for this compound involves precise cyclization steps to form the heterocyclic ring system. Achieving high industrial purity requires optimized reaction conditions that minimize byproduct formation. Common impurities may include unreacted precursors or ring-opened derivatives, which must be removed through crystallization or distillation.
A robust synthesis route is characterized by high atom economy and reproducible yields. In an industrial setting, the focus shifts from merely achieving the chemical transformation to ensuring that the process is scalable and safe. Variations in the manufacturing process can lead to fluctuations in impurity profiles, which may negatively impact downstream coupling reactions. Therefore, partnering with a supplier who maintains strict control over their synthesis parameters is crucial for consistent production outcomes.
Quality Control and COA Interpretation
When evaluating suppliers, the Certificate of Analysis (COA) is the primary document for verifying quality. For 4,4-dimethylisoxazolidin-3-one, a comprehensive COA should include more than just the assay percentage. Key quality control metrics include:
- Assay (HPLC/GC): Industrial standards typically demand ≥99.0% purity. Lower grades may contain excessive impurities that complicate purification.
- Loss on Drying (LOD): Moisture content must be controlled to prevent hydrolysis during storage or reaction.
- Residual Solvents: Compliance with ICH Q3C guidelines is necessary, especially if the intermediate is used in pharmaceutical applications.
- Heavy Metals: Strict limits ensure safety and compliance with environmental regulations.
Interpreting these data points allows procurement teams to assess risk. For example, high moisture content can lead to clumping or reduced reactivity. NINGBO INNO PHARMCHEM CO.,LTD. provides detailed COAs with every shipment, ensuring transparency and traceability for all bulk orders.
Commercial Considerations and Bulk Procurement
Pricing dynamics for fine chemicals are influenced by raw material costs, energy consumption, and purification complexity. While small-scale research quantities often command a high bulk price per gram due to packaging and handling fees, true industrial procurement focuses on metric ton scalability. Market data indicates significant price disparities between research-grade suppliers and industrial manufacturers.
When sourcing high-purity 4,4-Dimethyl-1,2-oxazolidin-3-one, buyers should prioritize suppliers with established production capacity rather than trading companies. Direct manufacturers can offer better technical support, consistent quality, and more competitive pricing structures for long-term contracts. Additionally, verifying the HS Code (2934999090) is essential for accurate customs clearance and tariff calculation during international shipping.
Safety and Handling
Safety data indicates that this compound carries GHS06 danger symbols with hazard statements H301, H311, and H331. Proper personal protective equipment (PPE) including gloves and eye protection is mandatory during handling. Precautionary statements such as P261 (avoid breathing dust/fume/gas/mist/vapours/spray) and P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes) should be strictly followed in the facility.
Conclusion
Securing a reliable supply of 4,4-dimethyl-3-isoxazolidinone is a strategic decision for any organization involved in agrochemical or pharmaceutical synthesis. By focusing on verified industrial purity, rigorous QC metrics, and transparent manufacturing processes, companies can mitigate production risks. NINGBO INNO PHARMCHEM CO.,LTD. remains committed to delivering high-quality intermediates that meet the exacting standards of the global chemical industry.