Global Manufacturer 4-(3-Chloropropyl)-1-Piperazine Ethanol Bulk Price Analysis
- Technical Grade: High purity grade material suitable for complex pharmaceutical intermediate synthesis.
- Procurement: Tiered bulk price models available for industrial scale orders with stable supply chains.
- Logistics: Flexible FOB and CIF shipping options ensuring compliant global delivery.
In the landscape of modern organic synthesis, securing reliable sources for specialized heterocyclic building blocks is critical for maintaining production schedules. 4-(3-Chloropropyl)-1-Piperazine Ethanol (CAS: 57227-28-8) serves as a vital pharmaceutical intermediate used in the development of various active pharmaceutical ingredients (APIs). As demand fluctuates based on downstream drug production, understanding the technical specifications and commercial dynamics of this compound is essential for procurement managers and process chemists. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier global manufacturer committed to delivering consistent quality and competitive commercial terms for this essential chemical reagent.
Technical Specifications and Physical Properties
For process chemists evaluating this compound for scale-up, precise physical data is necessary to design reaction conditions and purification protocols. The material typically presents as a colorless to light-yellow liquid with a characteristic amine-like odor. Its solubility profile makes it highly versatile for organic transformations, being soluble in common organic solvents like ethanol, methanol, and dichloroprote while remaining only slightly soluble in water. Below is a detailed specification table based on industrial standards.
| Property | Specification |
|---|---|
| Chemical Formula | C9H19ClN2O |
| Molecular Weight | 206.71 g/mol |
| CAS Number | 57227-28-8 |
| Appearance | Colorless to light-yellow liquid |
| Boiling Point | Approximately 270 - 280 °C |
| Density | 1.05 - 1.15 g/cm³ |
| Flash Point | > 100 °C |
| pH in Solution | Basic (pH 8 - 10) |
Synthesis Route and Industrial Purity Standards
The manufacturing process for this compound requires precise control over alkylation reactions to minimize impurities such as dialkylated byproducts or unreacted starting materials. A robust synthesis route typically involves the nucleophilic substitution of piperazine derivatives with appropriate chloro-alcohol precursors. Achieving industrial purity levels often necessitates vacuum distillation or recrystallization steps to ensure the final product meets the stringent requirements of medicinal chemistry applications.
When sourcing high-purity 4-(3-Chloropropyl)-1-piperazine Ethanol, buyers should prioritize suppliers who provide comprehensive Certificate of Analysis (COA) documentation. This document verifies critical parameters such as assay content, water content, and residual solvent levels. In scenarios where a COA is not immediately available on a digital platform, reputable manufacturers encourage direct communication with technical support teams. Clients should provide the specific batch number and product name to expedite the retrieval of quality data, ensuring transparency and safety in the supply chain.
Alternative nomenclature such as 2-(4-(3-chloropropyl)piperazin-1-yl)ethanol or 1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine may appear in literature, but consistent CAS registration ensures accurate identification during procurement. Maintaining a high purity grade is non-negotiable for downstream reactions where impurities could catalyze unwanted side reactions or complicate purification workflows.
Tiered Pricing Models for Volume Orders
The bulk price of 4-(3-Chloropropyl)-1-Piperazine Ethanol is heavily influenced by order volume, raw material costs, and purification complexity. Manufacturers typically structure pricing into tiers to accommodate both R&D-scale requirements and full-scale commercial production.
- Sample and R&D Scale: Small quantities (e.g., 500g to 5kg) are priced higher per unit to cover packaging and quality control overheads. This tier is essential for process development and feasibility studies.
- Pilot Plant Scale: Orders ranging from 25kg to 100kg often benefit from moderate discounts. This tier supports clinical trial material production.
- Commercial Bulk: Quantities exceeding 200kg qualify for the most competitive rates. Long-term contracts at this level often lock in pricing to mitigate market volatility.
Flexible payment terms are often available for established partners, facilitating smoother cash flow management for large-scale procurement initiatives. Competitive pricing structures are designed to fit various budget constraints while maintaining the integrity of the chemical supply.
FOB vs CIF Shipping Cost Analysis
Logistics play a pivotal role in the landed cost of chemical intermediates. Buyers must evaluate Incoterms carefully to understand liability and cost distribution. FOB (Free on Board) terms place the responsibility on the buyer once the goods are loaded at the port of origin, offering greater control over freight forwarding and insurance. Conversely, CIF (Cost, Insurance, and Freight) includes the cost of transportation and insurance to the destination port, simplifying the process for the buyer but potentially reducing visibility into shipping logistics.
Proper packaging is critical for maintaining product integrity during transit. The compound is shipped in well-sealed containers, adhering to strict chemical transportation regulations. Packaging ensures protection from environmental factors such as moisture and air exposure, which could degrade the quality of the amine functionality. Storage recommendations dictate keeping the material in a cool, dry place away from direct sunlight and incompatible substances like oxidizing agents.
2026 Market Forecast and Price Trends
Looking toward 2026, the market for piperazine derivatives is expected to remain stable, driven by consistent demand in the pharmaceutical and agrochemical sectors. However, price trends may be influenced by global regulatory changes regarding chemical manufacturing and environmental compliance. A stable supply chain is crucial to navigating these potential fluctuations.
Manufacturers who invest in advanced production capabilities and rigorous quality protocols are better positioned to offer consistent efficacy and safety standards. As the industry evolves, the demand for transparent sourcing and verified quality data will continue to rise. NINGBO INNO PHARMCHEM CO.,LTD. remains dedicated to empowering global customers with safe, efficient, and compliant chemical solutions, ensuring that procurement teams can rely on a steady flow of high-quality intermediates for their synthesis pipelines.
Conclusion
Securing a reliable supply of 4-(3-Chloropropyl)-1-Piperazine Ethanol requires a partner who understands both the technical nuances of the molecule and the commercial realities of global trade. By focusing on industrial purity, transparent quality documentation, and flexible shipping terms, buyers can optimize their procurement strategies. For detailed quotes, technical data sheets, or to discuss custom synthesis requirements, engaging directly with a qualified manufacturer ensures the best outcomes for your production goals.