Sourcing 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone
Technical Specifications and Purity Grades of 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone (CAS 58113-30-7)
As a key pharmaceutical intermediate, 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone—also referred to as 4-(3-Chloropropoxy)-3-Methoxyacetophenone or 3-Chloro-1-(4-Acetyl-2-Methoxyphenoxy)-Propane—demands rigorous quality control. Our industrial-grade product is manufactured under strict process controls to ensure consistent purity levels suitable for downstream synthesis, particularly as an Iloperidone intermediate. Standard specifications typically target a purity of ≥98.0% by HPLC, with individual impurities controlled to ≤0.5%. However, for sensitive applications, higher purity grades (≥99.0%) are available upon request. The compound appears as an off-white to pale yellow crystalline solid, with a melting point range of 58–62°C. Please refer to the batch-specific COA for exact numerical values, as slight variations may occur due to production lot adjustments.
For procurement managers evaluating this high-purity API intermediate, understanding the synthesis route is critical. Our optimized manufacturing process, detailed in our technical article on the optimized synthesis route for Iloperidone intermediate CAS 58113-30-7, minimizes by-product formation and ensures a reliable supply chain. This route leverages advanced catalytic methods to achieve high yields while maintaining cost efficiency, making it a competitive choice for bulk sourcing.
| Parameter | Standard Grade | High Purity Grade |
|---|---|---|
| Assay (HPLC) | ≥98.0% | ≥99.0% |
| Melting Point | 58–62°C | 58–62°C |
| Appearance | Off-white to pale yellow solid | White to off-white solid |
| Single Impurity | ≤0.5% | ≤0.2% |
| Loss on Drying | ≤0.5% | ≤0.3% |
Critical COA Parameters and Batch-to-Batch Consistency for Industrial Sourcing
When sourcing 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone at scale, the Certificate of Analysis (COA) is your primary assurance of quality. Beyond the standard assay and melting point, we emphasize parameters that directly impact downstream processing: residual solvents (typically controlled to ICH Q3C limits), heavy metals (≤10 ppm), and water content (Karl Fischer titration). Our quality system ensures batch-to-batch consistency through in-process controls and final product testing. For instance, the HPLC chromatogram profile is monitored to confirm the absence of unknown impurities above 0.1%. This level of detail is crucial for pharmaceutical intermediate buyers who require predictable performance in their synthesis routes.
We also provide supplementary data such as IR and NMR spectra upon request, enabling full characterization. Our commitment to transparency means that every shipment includes a comprehensive COA, and we archive retention samples for three years to support any future investigations. This rigorous approach aligns with the expectations of global manufacturers seeking a reliable 3-(p-Acetyl-o-Methoxyphenoxy)-Propyl Chloride supplier.
Bulk Packaging, Storage, and Handling: IBC Totes, 210L Drums, and Stability Data
For industrial quantities, we offer flexible packaging solutions tailored to your logistics needs. Standard options include 25 kg fiber drums, 210L steel drums, and 1000L IBC totes. The compound is classified as a non-hazardous solid under most transport regulations, but proper handling procedures should be followed: store in a cool, dry place (recommended 2–8°C for long-term stability), away from direct sunlight and moisture. Stability studies indicate that when stored under these conditions, the product maintains its purity for at least 24 months. For bulk shipments, we use desiccant packs and vacuum-sealed liners to prevent degradation during transit.
Our logistics team can coordinate door-to-door delivery, including customs clearance for international orders. While we do not claim EU REACH compliance, we ensure that all packaging meets international standards for physical integrity and labeling. For high-volume contracts, we can arrange dedicated lot production to minimize batch-to-batch variability, a service appreciated by buyers integrating this Iloperidone intermediate into validated processes.
Non-Standard Field Observations: Viscosity Behavior and Crystallization Management in Sub-Zero Environments
Through years of field experience, we've observed that 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone exhibits unique physical behaviors under extreme conditions. While the compound is a solid at room temperature, during melting or dissolution in certain solvents, its viscosity can shift unexpectedly at sub-zero temperatures. For example, when preparing solutions for reactions at -20°C, the material may form a supercooled liquid with higher viscosity than anticipated, potentially affecting mixing efficiency. To mitigate this, we recommend pre-warming the solvent or using mechanical agitation.
Another practical insight relates to crystallization: if the molten product is cooled too rapidly, it can form an amorphous glass rather than a crystalline solid, which may complicate handling. Controlled cooling at 1–2°C per minute typically yields a uniform crystalline mass. These non-standard parameters are rarely documented but are critical for process chemists scaling up reactions. Our technical support team can provide guidance based on real-world usage, ensuring smooth integration into your manufacturing process.
Supply Chain Reliability and Drop-in Replacement Strategy for Seamless Integration
As a global manufacturer, we position our 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone as a drop-in replacement for existing sources, offering identical technical parameters and performance. Our production capacity of multi-ton lots per month ensures uninterrupted supply, even during market fluctuations. By maintaining strategic raw material inventories and dual sourcing for key precursors, we mitigate risks of shortages. For buyers currently using alternative suppliers, our product can be qualified through a simple comparative analysis: match the HPLC profile, melting point, and impurity pattern to your incumbent material. In most cases, no process adjustments are needed.
Our optimized synthesis route for Iloperidone intermediate CAS 58113-30-7 further underscores our technical expertise, ensuring that the product meets the stringent requirements of pharmaceutical manufacturing. We also offer custom synthesis services for related intermediates, providing a one-stop solution for your supply chain needs.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone?
Our standard MOQ is 1 kg for sample evaluation. For commercial orders, we typically supply in 25 kg drums, but we can accommodate smaller or larger quantities based on project needs. Contact our sales team for a tailored quotation.
Can you provide a COA and MSDS before shipment?
Yes, we provide a preliminary COA and Material Safety Data Sheet (MSDS) with every quotation. The final COA is included with the shipment, and we can also share batch-specific analytical data upon request.
What is the typical lead time for bulk orders?
For orders up to 100 kg, lead time is usually 2–3 weeks after order confirmation. Larger quantities may require 4–6 weeks, depending on production scheduling. We maintain safety stocks of key intermediates to expedite urgent requests.
Is this product suitable for GMP manufacturing?
Our standard grade is produced under ISO 9001-certified quality management, but it is not manufactured under full cGMP. For GMP applications, we can offer a higher purity grade with enhanced documentation; please discuss your requirements with our technical team.
How do you ensure batch-to-batch consistency?
We employ rigorous in-process controls and final product testing using validated HPLC methods. Each batch is compared against a reference standard, and we archive retention samples for three years. Our statistical process control charts monitor critical parameters to detect any trends.
Sourcing and Technical Support
In summary, 1-[4-(3-Chloropropoxy)-3-Methoxyphenyl]Ethanone (CAS 58113-30-7) is a versatile pharmaceutical intermediate with a well-established role in synthesizing active pharmaceutical ingredients like Iloperidone. Our commitment to quality, supply chain reliability, and technical support makes us a preferred partner for global buyers. Whether you need a single drum for R&D or multi-ton quantities for commercial production, we have the capabilities to meet your demands. Ready to optimize your supply chain? Reach out to our logistics team today for comprehensive specifications and tonnage availability.