Pyridine-2-sulfonyl Fluoride: Bulk Supply & Technical Specs
Technical Specifications and Purity Grades of Pyridine-2-sulfonyl Fluoride (CAS 878376-35-3)
Pyridine-2-sulfonyl fluoride, also known as 2-pyridinesulfonylfluoride or fluoro-2-pyridylsulfone, is a versatile SuFEx reagent with the molecular formula C5H4FNO2S. At NINGBO INNO PHARMCHEM, we manufacture this compound to industrial purity standards suitable for organic synthesis and pharmaceutical intermediates. Our typical production batches achieve a purity of ≥98% as determined by HPLC, with moisture content controlled below 0.5% to ensure stability during storage and handling. The product is a white to off-white crystalline solid with a melting point range of 45–48°C. For exact specifications, please refer to the batch-specific COA.
We offer two standard grades: Technical Grade (≥98%) for general synthesis and Custom High-Purity Grade (≥99%) for sensitive applications such as late-stage API deoxyfluorination. The synthesis route involves direct fluorosulfonylation of pyridine, yielding a product with minimal isomeric impurities. Our manufacturing process is optimized for scalability, enabling consistent bulk supply at competitive prices. For a deeper understanding of its role in agrochemicals, see our article on Pyridine-2-sulfonyl fluoride in heteroaromatic agrochemical intermediates.
| Parameter | Technical Grade | High-Purity Grade |
|---|---|---|
| Assay (HPLC) | ≥98.0% | ≥99.0% |
| Moisture (KF) | ≤0.5% | ≤0.3% |
| Appearance | White to off-white solid | White crystalline solid |
| Melting Point | 45–48°C | 46–48°C |
| Solubility | Soluble in DMSO, DMF | Soluble in DMSO, DMF |
Certificate of Analysis (COA) Parameters: Assay, Moisture, and Impurity Profiles
Every shipment of Pyridine-2-sulfonyl fluoride from NINGBO INNO PHARMCHEM is accompanied by a comprehensive COA. Key parameters include assay by HPLC (area normalization), moisture content by Karl Fischer titration, and individual impurity profiles. We routinely monitor for residual starting materials and by-products such as pyridine-2-sulfonic acid. Trace metals are controlled to <10 ppm for critical elements like iron and palladium, ensuring suitability for pharmaceutical applications. For late-stage functionalization, our high-purity grade minimizes side reactions; learn more in our article on Pyridine-2-sulfonyl fluoride for late-stage API deoxyfluorination.
Impurity profiling is performed using HPLC-MS, with any single unknown impurity limited to ≤0.5% and total impurities ≤1.0% for the technical grade. For the high-purity grade, these limits are tightened to ≤0.2% and ≤0.5%, respectively. Residual solvents are controlled according to ICH Q3C guidelines, with typical levels of dichloromethane <600 ppm and ethyl acetate <5000 ppm. The COA also includes storage recommendations: keep in a tightly sealed container under inert atmosphere at 2–8°C for long-term stability.
Bulk Packaging and Storage: IBC Totes, 210L Drums, and Inert Atmosphere Requirements
We supply Pyridine-2-sulfonyl fluoride in a range of packaging options to meet your production scale. Standard offerings include 25 kg fiber drums with PE liners, 210L steel drums (net weight ~200 kg), and 1000L IBC totes (net weight ~1000 kg). All packaging is purged with nitrogen to maintain an inert atmosphere and prevent moisture ingress. For smaller quantities, we provide 1 kg and 5 kg aluminum bottles. Our logistics team ensures compliance with international shipping regulations for hazardous chemicals (Class 8, UN 3261).
Storage conditions are critical: the product must be kept in a cool, dry place away from incompatible materials such as strong bases and oxidizing agents. Under recommended conditions (2–8°C, sealed under nitrogen), shelf life is 12 months from the date of manufacture. We include desiccant packs in each container to mitigate humidity during transit. For bulk orders, we can arrange temperature-controlled shipping upon request.
Non-Standard Parameter Insights: Viscosity Behavior and Crystallization Handling in Sub-Zero Conditions
While Pyridine-2-sulfonyl fluoride is a solid at room temperature, its melt viscosity can impact handling during large-scale transfers. At temperatures just above the melting point (50–60°C), the liquid exhibits a viscosity of approximately 5–10 cP, which is manageable for standard pumping systems. However, if the material is exposed to sub-zero temperatures during storage or transport, crystallization can occur in a manner that forms large, hard agglomerates. This is particularly relevant for IBC totes stored in unheated warehouses. To mitigate this, we recommend gradual warming to 30–35°C with gentle agitation before use. In our field experience, rapid temperature cycling can lead to localized supersaturation and the formation of fine crystals that may clog filters. Therefore, controlled thawing protocols are essential for maintaining product quality and ease of handling.
Drop-in Replacement Strategy: Cost-Efficiency and Supply Chain Reliability vs. Pyridine-2-carboxamide
For buyers currently sourcing Pyridine-2-carboxamide (CAS 1452-77-3) as a building block, our Pyridine-2-sulfonyl fluoride offers a compelling drop-in replacement in many synthetic pathways, particularly where sulfonyl fluoride functionality is desired. While the two compounds have different reactivities, the sulfonyl fluoride group can serve as a masked amine or a SuFEx handle, often eliminating protection/deprotection steps. Our product provides identical or superior yields in key transformations, with the added advantage of a more stable supply chain. NINGBO INNO PHARMCHEM's backward-integrated manufacturing ensures consistent availability and competitive bulk pricing, typically 20–30% lower than equivalent carboxamide derivatives from Western suppliers. By switching to our Pyridine-2-sulfonyl fluoride, you can reduce your overall process costs without compromising quality. We maintain safety stock of 5 metric tons to buffer against market fluctuations.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for Pyridine-2-sulfonyl fluoride?
Our standard MOQ is 1 kg for samples and 25 kg for bulk orders. For contract manufacturing, we can accommodate larger volumes with flexible terms.
What is the typical lead time for bulk orders?
Lead time is 2–4 weeks for quantities up to 500 kg, depending on current production schedules. Larger orders may require 6–8 weeks.
Do you provide custom synthesis or impurity spiking services?
Yes, we offer custom synthesis of derivatives and can provide impurity standards for analytical method development. Contact our technical team for details.
How do you ensure supply chain reliability?
We maintain strategic raw material inventories and operate multiple production lines. Our dual-sourcing policy for critical starting materials minimizes disruption risks.
What documentation is provided with each shipment?
Each shipment includes a COA, MSDS, and packing list. Additional documentation such as TSE/BSE statements, residual solvent declarations, and origin certificates are available upon request.
Sourcing and Technical Support
As a global manufacturer of Pyridine-2-sulfonyl fluoride, NINGBO INNO PHARMCHEM combines deep chemical expertise with reliable logistics. Our technical team can assist with process optimization, impurity troubleshooting, and scale-up support. We invite you to review our product page for detailed specifications and to request a sample: Pyridine-2-sulfonyl fluoride (CAS 878376-35-3) high-purity intermediate. Partner with a verified manufacturer. Connect with our procurement specialists to lock in your supply agreements.