5-Bromo-2-Hydroxy-3-Picoline: Halogen Exchange Impurity Control
Technical Specifications and Purity Grades of 5-Bromo-2-Hydroxy-3-Picoline for Pyridine Herbicide Synthesis
In the synthesis of pyridine-based herbicides, the building block 5-Bromo-2-Hydroxy-3-Picoline (CAS 89488-30-2) serves as a critical intermediate. This compound, also known as 5-bromo-3-methylpyridin-2-ol or 5-bromo-3-methyl-1H-pyridin-2-one, is valued for its reactivity in cross-coupling and substitution reactions. For R&D managers and procurement specialists, understanding the technical specifications is paramount to ensure seamless integration into existing synthetic routes. Our product is manufactured under strict quality control to meet the demands of industrial-scale herbicide production. Typical purity grades available include ≥98% (HPLC) and ≥99% (HPLC), with the latter recommended for sensitive halogen exchange steps where trace impurities can significantly impact yield and selectivity. The following table summarizes the key technical parameters:
| Parameter | Specification (Typical) | Test Method |
|---|---|---|
| Appearance | Yellow to light brown crystalline powder | Visual |
| Purity (HPLC) | ≥99.0% | HPLC |
| Melting Point | Please refer to the batch-specific COA | DSC |
| Water Content (KF) | ≤0.5% | Karl Fischer |
| Residue on Ignition | ≤0.1% | Gravimetric |
| Heavy Metals (as Pb) | ≤10 ppm | ICP-MS |
These specifications are designed to match or exceed those of established suppliers, positioning our 5-Bromo-2-Hydroxy-3-Picoline as a reliable drop-in replacement. For detailed batch-specific data, always consult the Certificate of Analysis (COA) provided with each shipment.
Halogen Exchange Impurity Profiling: Critical COA Parameters and Batch Consistency
Halogen exchange reactions, particularly in the context of pyridine herbicide synthesis, are highly sensitive to the presence of isomeric or over-halogenated impurities. When using 5-Bromo-2-Hydroxy-3-Picoline, the primary concern is the potential carryover of 5-bromo-2-hydroxy-3-nitro-4-picoline (CAS 228410-90-0) or other nitro derivatives from upstream processes. Our manufacturing process is specifically designed to minimize such impurities, ensuring that the bromine atom is exclusively at the 5-position. Key COA parameters that procurement managers should scrutinize include:
- Related Substances by HPLC: Individual unspecified impurities are controlled to ≤0.5%, with total impurities ≤1.0%. Special attention is given to the 4-methyl analog and any nitro-containing species.
- Residual Solvents: Class 2 solvents like dichloromethane or toluene are monitored to ensure compliance with ICH Q3C guidelines, even though formal REACH certification is not claimed.
- Assay by Titration: Non-aqueous titration provides an orthogonal purity check, confirming the absence of acidic or basic impurities that could interfere with subsequent reactions.
Batch-to-batch consistency is critical for process validation. We maintain rigorous in-process controls and provide comprehensive analytical documentation. For those integrating this intermediate into a synthetic route involving 5-bromo-3-methylpyridin-2(1H)-one tautomers, it is worth noting that the solid-state form is predominantly the hydroxyl tautomer, which can influence dissolution kinetics in certain solvents. This aspect is further discussed in our article on solvent compatibility and sourcing strategies.
Industrial-Scale Handling: Bulk Packaging, Storage Stability, and Non-Standard Parameter Considerations
For tonnage-scale procurement, logistics and handling are as important as chemical purity. Our 5-Bromo-2-Hydroxy-3-Picoline is typically supplied in 25 kg fiber drums with double PE liners, or in 210L steel drums for larger quantities. For high-volume orders, we can accommodate IBC totes. The product is classified as a solid with a recommended storage condition of sealed, dry, at room temperature. However, field experience has revealed a non-standard parameter: at sub-zero temperatures (e.g., during winter transport), the crystalline powder may exhibit slight caking or clumping due to trace moisture absorption. This does not affect chemical purity but can impact flowability in automated dispensing systems. To mitigate this, we advise tempering the drums to 15–25°C before use and ensuring desiccant packs are intact. Detailed guidance on winter logistics is available in our dedicated article on bulk supply and drum integrity during cold weather.
Another practical consideration is the color variation. While the typical appearance is yellow, occasional batches may present as light brown due to trace oxidation products. This color shift is within specification and does not correlate with purity or reactivity. For processes where color is a critical quality attribute (e.g., final API appearance), we can provide additional purification steps upon request.
Supply Chain and Cost Efficiency: Drop-in Replacement for Seamless Integration in Herbicide Manufacturing
As a global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. offers a robust supply chain for 5-Bromo-2-Hydroxy-3-Picoline, ensuring competitive bulk pricing and reliable delivery. Our product is positioned as a drop-in replacement for existing sources, matching technical specifications while offering cost advantages through optimized synthesis routes and economies of scale. By choosing our 5-bromo-3-methylpyridin-2-ol, procurement managers can reduce supply chain risk without requalification delays. We maintain safety stock and offer flexible MOQs, from pilot-scale 1 kg samples to multi-ton contracts. For a seamless transition, we provide full analytical support and sample batches for head-to-head comparison. The primary internal link to our product page can be found here: 5-Bromo-2-Hydroxy-3-Picoline high-purity intermediate for organic synthesis.
Frequently Asked Questions
What is the typical minimum order quantity (MOQ) for 5-Bromo-2-Hydroxy-3-Picoline?
Our standard MOQ is 1 kg for sample evaluation. For commercial production, we can supply from 25 kg to multi-ton lots, with pricing adjusted accordingly.
How do you ensure batch-to-batch consistency for halogen exchange reactions?
We employ strict in-process controls and release testing, including HPLC purity, related substances, and water content. Each batch is accompanied by a comprehensive COA, and we can provide pre-shipment samples for customer QC checks.
Can you provide custom packaging or labeling?
Yes, we offer customized packaging solutions, including private labeling and specific drum sizes, to meet your operational requirements. Please contact our logistics team for details.
What is the shelf life of this product under recommended storage conditions?
When stored in sealed containers at room temperature and protected from moisture, the product is stable for at least 24 months. Retest dates are indicated on the COA.
Do you offer any impurity standards or reference materials for method development?
We can supply characterized impurity standards, such as the 4-methyl isomer or the des-bromo analog, to support your analytical method validation. Inquire with our technical team.
Sourcing and Technical Support
In summary, 5-Bromo-2-Hydroxy-3-Picoline is a versatile building block for pyridine herbicide synthesis, and our high-purity grade ensures reliable performance in halogen exchange and downstream chemistry. With a focus on impurity control, robust logistics, and cost-effective supply, NINGBO INNO PHARMCHEM is your partner for scaling up from R&D to commercial production. Ready to optimize your supply chain? Reach out to our logistics team today for comprehensive specifications and tonnage availability.