2-Aminophenol Hemisulfate Bulk Procurement Specs & Purity
2-Aminophenol Hemisulfate Bulk Procurement Specs and Industrial Purity Grades
Procuring 2-Aminophenol Hemisulfate (CAS: 67845-79-8) for industrial synthesis requires rigorous validation of chemical identity beyond standard catalog listings. As a critical organic synthesis precursor, this compound serves as a key building block for pharmaceuticals and specialized dyes. Buyers must distinguish between generic salt listings and specific hemisulfate stoichiometry to ensure reaction consistency. At NINGBO INNO PHARMCHEM CO.,LTD., we prioritize technical grade transparency, ensuring that the molecular formula C12H16N2O6S aligns with your process requirements.
Industrial purity grades typically target assay values above 98.00%, but the critical differentiator lies in the impurity profile. Trace metals, particularly iron, can catalyze unwanted oxidation during storage, shifting the material color from off-white to dark grey. Procurement specifications must explicitly define acceptable color ranges and heavy metal limits to prevent downstream contamination. When evaluating suppliers, request data on the synthesis route to understand potential byproduct residues that standard COAs might omit.
For detailed product specifications and availability, review our high-purity 2-Aminophenol Hemisulfate Salt portfolio. Ensuring the correct grade is selected early prevents costly reformulation later in the production cycle.
Validating COA Loss on Drying ≤0.5% Against BLD Pharm MDL No. MFCD23701251 Data
Loss on Drying (LOD) is a critical parameter for hygroscopic salts. While generic listings may accept higher moisture content, precise synthetic applications often require LOD ≤0.5% to maintain stoichiometric accuracy in reaction charges. When cross-referencing against specific database identifiers like MDL No. MFCD23701251, procurement teams should verify that the provided COA reflects vacuum-dried conditions rather than ambient equilibrium.
High moisture content can lead to hydrolysis risks during storage, particularly if the packaging integrity is compromised. We recommend validating the LOD method used by the supplier; Karl Fischer titration often provides more accurate water content data than gravimetric loss on drying for this specific salt. If specific batch data is required for your validation protocol, please refer to the batch-specific COA provided upon request. Consistency in LOD ensures that the active amine content remains stable over the shelf life of the material.
Technical Specification Gaps: Differentiating MFCD23701251 From Generic MFCD00050842 Listings
A common procurement error involves conflating specific MDL numbers with generic database entries. MFCD00050842 is often associated with broader chemical listings that may not distinguish between the free base and the hemisulfate salt form clearly in all contexts. In contrast, referencing MFCD23701251 helps isolate the specific hemisulfate stoichiometry required for consistent molar calculations.
The table below outlines the technical divergence between generic industrial listings and specific intermediate grades required for sensitive synthesis:
| Parameter | Generic Industrial Listing | Specific Intermediate Grade (MFCD23701251 Ref) |
|---|---|---|
| CAS Number | 67845-79-8 | 67845-79-8 |
| Molecular Weight | Variable (Often Free Base) | 316.33 g/mol (Salt) |
| Melting Point | 173-177°C (Free Base) | 59-60°C (Hemisulfate) |
| Assay Purity | ≥95.0% | ≥98.00% |
| Loss on Drying | ≤1.0% | ≤0.5% (Target) |
| Appearance | Variable (Grey to White) | Off-white to Light Grey |
Utilizing the correct MDL reference ensures that the melting point specification aligns with the salt form (59-60°C) rather than the free base (173-177°C), preventing material rejection during incoming quality control. This distinction is vital for maintaining batch-to-batch reproducibility in continuous manufacturing processes.
Bulk Packaging Protocols for Hygroscopic 2-Aminophenol Hemisulfate Salt Stability
Given the hygroscopic nature of 2-Aminophenol Hemisulfate, physical packaging protocols are as critical as chemical specifications. Standard bulk shipments utilize 25kg fiber drums with double polyethylene liners or 500kg IBC totes with aluminum foil inner bags. However, field experience indicates that environmental conditions during transit significantly impact material flowability.
A non-standard parameter often overlooked in standard COAs is the material's tendency to cake or bridge in hoppers when exposed to temperatures below 10°C during winter shipping. This physical change does not alter chemical purity but can disrupt automated dosing systems. To mitigate this, we recommend specifying heated storage upon arrival or allowing drums to acclimate to room temperature before opening. For larger volume requirements involving technical grade materials, discussing 2-Aminophenol Hemisulfate substitute for hair dye applications may reveal alternative packaging configurations better suited for high-humidity environments.
Proper sealing is mandatory. Once opened, the material should be stored under an inert atmosphere or in a desiccator to prevent moisture uptake. Failure to adhere to these packaging protocols can result in clumping that mimics degradation, leading to unnecessary quality investigations.
Procurement Compliance Checklist for MDL No. MFCD23701251 Data Cross-Reference
To streamline the vendor qualification process, procurement managers should utilize a standardized checklist when evaluating sources for CAS 67845-79-8. This ensures all technical and commercial variables are accounted for before contracting.
- Identity Verification: Confirm CAS 67845-79-8 and MDL No. MFCD23701251 on the COA.
- Purity Assay: Verify HPLC or GC method details and retention times.
- Moisture Content: Ensure LOD or Karl Fischer water content meets ≤0.5% targets.
- Packaging Integrity: Confirm double-liner usage for hygroscopic protection.
- Storage Conditions: Validate supplier recommendations match your facility capabilities (e.g., -20°C Freezer vs. Ambient).
- Traceability: Request batch numbers for full lineage tracking.
Adhering to this checklist minimizes the risk of receiving off-spec material that could halt production lines. NINGBO INNO PHARMCHEM CO.,LTD. supports this validation process with comprehensive documentation packages tailored to audit requirements.
Frequently Asked Questions
What is the typical lead time for bulk orders of 2-Aminophenol Hemisulfate?
Lead times vary based on current inventory levels and production scheduling. Standard stock items typically ship within 5-7 business days, while custom batch production may require 2-4 weeks. Please contact our sales team for a confirmed schedule based on your required quantity.
Can the material be supplied in packaging other than 25kg drums?
Yes, we offer flexible packaging solutions including 500kg IBCs and smaller sample sizes for R&D validation. Custom packaging requests should be discussed during the quotation phase to ensure compatibility with shipping regulations.
How does the hemisulfate salt compare to the free base in terms of stability?
The hemisulfate salt form generally offers improved stability against oxidation compared to the free base, provided moisture is controlled. However, it is more hygroscopic, requiring stricter packaging protocols to maintain physical flowability.
Is technical documentation available for regulatory submissions?
We provide standard COAs, MSDS, and technical datasheets. For specific regulatory support documents, please submit a formal request detailing the jurisdiction and intended use case.
Sourcing and Technical Support
Securing a reliable supply chain for specialized intermediates requires a partner who understands both the chemical properties and the logistical challenges of hygroscopic salts. By focusing on precise MDL references and robust packaging protocols, you can ensure consistent production quality. For custom synthesis requirements or to validate our drop-in replacement data, consult with our process engineers directly.