Trimetazidine Dihydrochloride Bulk Price Per Kg 2026: Market Analysis & Procurement Guide
- Projected 2026 Pricing: Industrial bulk rates typically range between $50 and $520 USD per kilogram, heavily dependent on purity grades and order volume.
- Technical Specifications: CAS 13171-25-0, Molecular Weight 339.26, with strict melting point controls at 231-235 °C.
- Supply Chain Security: Partnering with a verified global manufacturer ensures consistent COA documentation and GMP standard compliance.
Trimetazidine Dihydrochloride, chemically identified as 1-(2,3,4-Trimethoxybenzyl)piperazine Dihydrochloride, remains a critical intermediate in the synthesis of anti-ischemic metabolic agents. As the pharmaceutical industry moves toward 2026, procurement strategies for this compound must balance cost efficiency with rigorous quality assurance. For large-scale production facilities, understanding the nuances of bulk price fluctuations is essential for maintaining viable margins on finished dosage forms such as modified-release tablets.
At NINGBO INNO PHARMCHEM CO.,LTD., we recognize that reliable supply chains are the backbone of pharmaceutical manufacturing. This analysis provides a technical breakdown of market pricing, synthesis considerations, and volume-based procurement structures tailored for industrial buyers seeking high-purity intermediates.
Market Price Trends Per Kilogram
The pricing landscape for Trimetazidine Dihydrochloride (CAS: 13171-25-0) exhibits significant variance based on the scale of procurement and the specified purity level. Market intelligence indicates a broad spectrum where laboratory-scale purchases can exceed $1,000 per kilogram equivalent, whereas industrial bulk orders stabilize significantly lower.
For the 2026 fiscal year, FOB prices for pharmaceutical grade material generally fall within the $50 to $520 USD per kilogram range. The lower end of this spectrum typically corresponds to technical grade material or massive tonnage contracts, while the upper end reflects high-purity batches accompanied by comprehensive analytical data. Buyers must account for the hygroscopic nature of the solid, which necessitates specialized packaging to prevent degradation during transit, potentially influencing the final landed cost.
Furthermore, regional supply chain dynamics play a crucial role. Sourcing from a established global manufacturer mitigates the risk of price volatility caused by raw material shortages in the piperazine or trimethoxybenzyl chloride supply chains. Consistency in pricing is often linked to the supplier's ability to maintain continuous production runs rather than batch-specific synthesis.
Technical Specifications and Synthesis Overview
Understanding the chemical profile of Trimetazidine Dihydrochloride is vital for quality control teams. The compound presents as a white to off-white solid with a molecular formula of C14H24Cl2N2O3 and a molecular weight of 339.26. Critical physical properties include a melting point between 231-235 °C and high solubility in water, which impacts downstream processing conditions.
The synthesis route typically involves the alkylation of piperazine with 2,3,4-trimethoxybenzyl chloride, followed by salt formation with hydrochloric acid. Achieving industrial purity requires meticulous control over reaction parameters to minimize impurities such as unreacted starting materials or over-alkylated byproducts. High-performance liquid chromatography (HPLC) is the standard method for verifying assay levels, with most commercial specifications requiring ≥98% purity.
| Property | Specification |
|---|---|
| CAS Number | 13171-25-0 |
| Molecular Formula | C14H24Cl2N2O3 |
| Molecular Weight | 339.26 g/mol |
| Melting Point | 231-235 °C |
| Appearance | White to Off-White Solid |
| Storage Conditions | Refrigerator (Hygroscopic) |
| Solubility | Freely soluble in water |
When sourcing high-purity Trimetazidine Dihydrochloride, buyers should verify that the Certificate of Analysis (COA) includes data on residual solvents and heavy metals, ensuring compliance with international pharmacopoeia standards.
Volume Based Discount Structures
Procurement costs are inversely proportional to order volume. Suppliers typically structure pricing tiers to incentivize larger commitments, which helps optimize production planning. For example, orders ranging from 1 kg to 25 kg often carry a premium due to the logistical overhead of packaging and quality testing per unit. Conversely, drum-level quantities (25 kg to 100 kg) and tonnage orders unlock significant discounts.
Buyers should negotiate based on annual consumption forecasts rather than single purchase orders. Locking in pricing for a 12-month period can protect against market fluctuations in raw material costs. Additionally, establishing a long-term contract with a supplier like NINGBO INNO PHARMCHEM CO.,LTD. often provides access to dedicated production slots, ensuring priority fulfillment during peak demand seasons.
Key Factors Influencing Bulk Discounts
- Order Frequency: Regular quarterly shipments often yield better terms than sporadic purchases.
- Payment Terms: Advance payment or Letter of Credit (LC) arrangements can reduce financial risk for the supplier, translating to lower unit costs.
- Packaging Requirements: Standard packaging (e.g., 25kg fiber drums) is more cost-effective than customized small-unit packaging.
Requesting Formal Bulk Quotations
To obtain an accurate quotation for the 2026 production cycle, procurement officers must provide detailed technical requirements. Vague requests often result in estimated pricing that does not reflect the true cost of pharmaceutical grade material. A formal Request for Quotation (RFQ) should specify the required purity level, packaging specifications, and destination port.
Quality assurance is paramount. Buyers should request sample batches for internal validation before committing to large volumes. This step verifies that the synthesis route employed by the manufacturer yields a product compatible with your specific formulation process. Technical support should be available to discuss stability data and compatibility with excipients.
In summary, securing a competitive bulk price for Trimetazidine Dihydrochloride requires a strategic approach that values technical consistency over lowest-cost bidding. By focusing on verified specifications, volume leverage, and reliable manufacturing partners, pharmaceutical companies can ensure a stable supply chain for this essential cardiovascular intermediate.