4-Bromo-1-Fluoro-2-Nitrobenzene Bulk Price Global Manufacturer Analysis
- Industrial purity ≥98.0% (GC) ensures optimal reaction yields.
- Tiered pricing models available for kilogram to metric ton scales.
- Comprehensive documentation including COA and MSDS provided.
In the realm of fine chemical intermediates, 4-Bromo-1-fluoro-2-nitrobenzene (CAS: 364-73-8) stands out as a critical building block for pharmaceutical and agrochemical synthesis. As a Fluorinated nitrobenzene derivative, this compound possesses unique reactivity profiles due to the presence of both halogen substituents and the nitro group on the aromatic ring. Procurement teams and process chemists require precise data regarding industrial purity, synthesis scalability, and logistics when evaluating supply chains for this material. This analysis provides a technical and commercial overview for sourcing this key intermediate from a reliable global manufacturer.
Technical Specifications and Synthesis Route
Understanding the physicochemical properties of 2-fluoro-5-bromonitrobenzene is essential for process optimization. The compound typically presents as a crystalline powder with a melting point approximately at 86°C and a formula weight of 220.00. In industrial applications, maintaining a purity level of ≥98.0% (GC) is standard to prevent side reactions during nucleophilic aromatic substitution. The synthesis route generally involves the nitration of bromofluorobenzene isomers, requiring strict temperature control to manage regioselectivity and minimize dinitro byproducts.
For process chemists scaling up reactions, the quality of the starting material directly impacts downstream yield. Impurities such as residual acids or isomeric bromides can complicate purification steps. Therefore, verifying the manufacturing process and quality control protocols of the supplier is paramount. When sourcing high-purity 4-Bromo-1-fluoro-2-nitrobenzene, buyers should prioritize suppliers who provide detailed gas chromatography data alongside their standard specifications.
Physical and Chemical Properties
| Property | Specification |
|---|---|
| Chemical Name | 4-Bromo-1-fluoro-2-nitrobenzene |
| CAS Number | 364-73-8 |
| Molecular Formula | C6H3BrFNO2 |
| Molecular Weight | 220.00 g/mol |
| Purity (GC) | ≥98.0% |
| Physical Form | Crystalline Powder |
| Melting Point | ~86°C |
Tiered Bulk Pricing Structures
The bulk price of Bromofluoronitrobenzene variants fluctuates based on raw material costs, energy consumption during nitration, and purification complexity. Most tiered pricing models are structured around quantity breaks. Small-scale research quantities (grams to kilograms) command a higher unit price due to packaging and handling overheads. Conversely, metric ton procurement typically secures the most competitive rates, reflecting the efficiencies of continuous processing and bulk logistics.
Procurement officers should anticipate volume discounts when committing to annual contracts. Suppliers often offer flexible pricing tiers for 25kg drums versus 200kg drums or bulk bags. It is crucial to request a formal quotation that delineates these tiers clearly. Additionally, custom synthesis options may be available for clients requiring specific particle sizes or alternative packaging configurations, though this may influence the final cost structure.
Global Manufacturer Direct Supply
Sourcing directly from a global manufacturer eliminates intermediary markups and ensures better traceability. NINGBO INNO PHARMCHEM CO.,LTD. operates as a premier manufacturer capable of supplying high-volume quantities with consistent quality assurance. Direct supply chains reduce the risk of counterfeit materials or improperly stored chemicals that may have degraded during multiple handoffs.
Reliability in supply is as critical as price. Production capacity must align with the buyer's projected demand to prevent bottlenecks in pharmaceutical or agrochemical manufacturing lines. A robust manufacturer will maintain safety stock levels and have contingency plans for raw material shortages. Partnering with an established entity like NINGBO INNO PHARMCHEM CO.,LTD. ensures that the supply chain remains resilient against market volatility.
Incoterms and Logistics Costs
Logistics constitute a significant portion of the landed cost for hazardous organic intermediates. Since this compound is classified under specific safety regulations, shipping requires compliant packaging and documentation. Common Incoterms include FOB (Free on Board) and CIF (Cost, Insurance, and Freight). Buyers should calculate the total landed cost, including insurance and inland transportation, rather than focusing solely on the ex-works price.
International shipping of nitro-compounds requires adherence to IMDG codes for sea freight. Proper classification ensures smooth customs clearance and avoids delays at ports of entry. Manufacturers experienced in global export will handle the complexities of hazardous material declarations, ensuring the product arrives safely and compliantly.
Documentation and Regulatory Compliance
Regulatory compliance is non-negotiable in the chemical industry. Every shipment must be accompanied by a comprehensive COA (Certificate of Analysis) verifying batch-specific purity and physical constants. Furthermore, a valid MSDS (Material Safety Data Sheet) is required to inform handlers of safety protocols, storage conditions, and emergency measures.
Additional documents such as Certificates of Origin (COO) may be necessary for customs duty exemptions or regulatory filings in specific jurisdictions. Ensuring that all documentation aligns with local regulations prevents costly delays and potential legal issues. Transparent suppliers provide these documents promptly upon request, facilitating a seamless procurement process.
Key Applications in Industry
- Pharmaceutical Intermediates: Used in the synthesis of kinase inhibitors and other targeted therapies.
- Agrochemicals: Serves as a precursor for herbicides and fungicides requiring fluorinated aromatic structures.
- Material Science: Utilized in the development of specialty polymers with enhanced thermal stability.
- R&D: Employed in laboratory settings for exploring nucleophilic substitution mechanisms.
In conclusion, securing a reliable supply of 4-Bromo-1-fluoro-2-nitrobenzene requires a partner who understands both the technical nuances of the chemistry and the commercial realities of global trade. By prioritizing industrial purity, transparent pricing, and comprehensive documentation, manufacturers can ensure uninterrupted production schedules and high-quality end products.