NINGBO INNO PHARMCHEM CO.,LTD. is a distinguished name in the chemical and pharmaceutical industries, renowned for its commitment to supplying high-quality chemical intermediates and specialized compounds. We dedicate ourselves to advancing scientific research and drug development by providing reliable and precisely synthesized materials. Among our premium offerings is 16-(Tert-butoxy)-16-oxohexadecanoic acid, a compound critical to various advanced chemical and pharmaceutical synthesis processes.

16-(Tert-butoxy)-16-oxohexadecanoic acid, identified by its CAS number 843666-27-3, is also known by several synonyms, including tert-Butyl hydrogen hexadecanedioate and Hexadecanedioic acid mono(1,1-dimethylethyl) ester. Its molecular formula is C20H38O4, and it has a molecular weight of 342.51. This compound typically presents as a white powder or crystal, characterized by a melting point of approximately 60 °C. Predicted properties include a boiling point of 444.6±18.0 °C and a density of 0.959±0.06 g/cm3. These precise specifications underscore its suitability for demanding applications where purity and consistent performance are paramount.

The versatility of 16-(Tert-butoxy)-16-oxohexadecanoic acid makes it an invaluable asset in the realm of laboratory research and development. Its primary utility lies in complex chemical and pharmaceutical synthesis. A significant application of this compound is its role as a non-cleavable linker in Antibody-Drug Conjugates (ADCs). ADCs represent a rapidly evolving class of highly potent biopharmaceutical drugs designed as a targeted therapy for cancer, combining the specificity of antibodies with the cytotoxic potency of chemotherapy. The stable nature of this non-cleavable linker ensures the integrity of the conjugate until it reaches its intended biological target, minimizing off-target toxicity.

Furthermore, 16-(Tert-butoxy)-16-oxohexadecanoic acid is recognized as a crucial PROTAC (Proteolysis-Targeting Chimeras) linker. PROTACs are innovative therapeutic modalities that hijack the cell's ubiquitin-proteasome system to degrade target proteins rather than merely inhibiting their function. This compound, with its alkyl chain structure, provides the necessary scaffold to connect a ligand binding to a target protein with another ligand recruiting an E3 ubiquitin ligase, thereby enabling targeted protein degradation. This mechanism holds immense promise for addressing 'undruggable' targets and developing novel treatments for various diseases, including cancer and neurodegenerative disorders.

As a leading manufacturer and supplier of specialized chemical compounds, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to meeting the stringent requirements of the pharmaceutical and biotech industries. We ensure that our 16-(Tert-butoxy)-16-oxohexadecanoic acid is produced under rigorous quality control standards, making it ideal for sensitive research and development activities. For optimal stability and longevity, the product should be stored sealed in a dry, room temperature environment.

For those looking to buy or purchase 16-(Tert-butoxy)-16-oxohexadecanoic acid, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive price options and reliable supply. Our extensive experience and robust manufacturing capabilities position us as a trusted supplier for this and many other high-purity chemical intermediates. Whether for academic research or industrial application, we are equipped to handle diverse quantity requirements, ensuring prompt and efficient delivery to support your critical projects. Contact us today to inquire about availability and pricing for this essential chemical. We are committed to fostering innovation by providing the foundational chemical components necessary for groundbreaking discoveries.