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D-Phenylglycinol CAS 56613-80-0: A Key Chiral Building Block

D-Phenylglycinol, identified by its Chemical Abstracts Service (CAS) number 56613-80-0, stands as a pivotal compound in advanced organic synthesis. This chiral β-amino alcohol, with the molecular formula C8H11NO and a molecular weight of 137.18, is highly valued for its distinctive stereochemical properties and broad utility across various chemical industries. It typically appears as a white to light yellow crystalline powder, signifying its high purity and quality, often exceeding 99.0% as determined by HPLC.


The inherent chirality of D-Phenylglycinol makes it an indispensable synthetic structural unit. Its unique chemical structure allows it to participate in highly selective reactions, making it a cornerstone for the creation of complex molecular architectures. Key physical characteristics include a melting point typically ranging from 76-79°C and a specific rotation of approximately -25.5° (c=6, MeOH), further confirming its enantiomeric purity and consistent quality. It exhibits slight solubility in water, but is more soluble in organic solvents such as methanol and chloroform, which is beneficial for various reaction conditions.


The applications of D-Phenylglycinol are diverse and critical, particularly in the pharmaceutical and fine chemical sectors. It is extensively utilized for preparing chiral imines or oxazolidines, which are crucial intermediates in the synthesis of a wide array of enantiomerically pure compounds. For instance, these intermediates can be further transformed to synthesize the two enantiomers of alpha-trifluoromethylproline, a valuable building block in drug discovery. Beyond pharmaceuticals, D-Phenylglycinol serves as a fundamental chiral building block in the development of agrochemicals and other fine chemicals, where precise stereochemical control is paramount. Its role in asymmetric reactions enables the creation of compounds with specific biological activities, minimizing unwanted side effects and enhancing efficacy.


Furthermore, D-Phenylglycinol contributes significantly to experimental applications and the development of new synthetic methodologies. Its function as a chiral auxiliary facilitates the production of optically pure compounds, ensuring high levels of stereochemical control in complex synthetic pathways. This makes it a crucial reagent for chemists seeking to innovate and produce diverse chemical compounds with exceptional purity and specificity. The meticulous synthesis processes employed for this compound, often involving reduction of D-phenylglycine under controlled conditions, guarantee its high quality and suitability for demanding applications.


For researchers and industries requiring this exceptional chiral building block, finding a reliable D-Phenylglycinol manufacturer and supplier is essential. Access to comprehensive product documents, including Certificates of Analysis (COA) and Safety Data Sheets (SDS), ensures transparency and adherence to global quality standards. When considering to buy D-Phenylglycinol or planning a significant purchase, it is advisable to engage with established providers known for their consistent purity and robust supply chain. Factors such as competitive price and efficient delivery contribute to a smooth procurement process, enabling seamless integration into various research and production activities.

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