2,4,5-Trifluorobenzoic acid (CAS: 446-17-3) is a highly valued organic compound, serving as a pivotal intermediate in various advanced chemical syntheses. Known also by its synonyms such as 2,4,5-trifluorobenzenecarboxylic acid or Benzoic acid, 2,4,5-trifluoro-, this compound boasts a molecular formula of C7H3F3O2 and a molecular weight of 176.09300. Its unique trifluorinated structure contributes to its specific reactivity and utility in specialized applications across the chemical industry.

The physical and chemical properties of 2,4,5-Trifluorobenzoic acid are well-defined, underscoring its stability and handling characteristics. It typically appears as a white to off-white powder, sometimes as a light yellow crystal powder. Key physical parameters include a density of approximately 1.536 g/cm³ and a melting point ranging between 94-96ºC, although some sources report it up to 99-101°C. The boiling point is around 241.9ºC, with a flash point of 100.1ºC, and an index of refraction of 1.49. These characteristics are crucial for its processing and integration into manufacturing workflows.

For industrial applications, the specification of 2,4,5-Trifluorobenzoic acid is meticulously controlled. Our product adheres to stringent quality standards, ensuring an assay of ≥98.0% purity and a maximum moisture content of ≤0.2%. This high purity is essential for its sensitive applications. Packaging is typically available in 25 kg drums, though flexible packaging options can be tailored to meet specific customer requirements. Proper storage in a cool, ventilated place is recommended to maintain its integrity and shelf life.

The primary applications of 2,4,5-Trifluorobenzoic acid lie in its role as a crucial intermediate. It is extensively utilized in the synthesis of pharmaceuticals, particularly for the production of quinolone antibacterial agents, such as Temafloxacin, a significant class of antibiotics. Its unique fluorine substituents enhance the biological activity and pharmacokinetic properties of the final drug products. Beyond pharmaceuticals, it is also a vital building block in the development of liquid crystal materials, contributing to the performance and stability of displays used in electronics. Its versatility makes it indispensable in advanced material science.

The synthesis of 2,4,5-Trifluorobenzoic acid can be achieved through various pathways, often involving fluorination and subsequent chemical transformations of related aromatic compounds. Common synthetic routes may start from precursors like tetrachloroisophthalonitrile, involving a series of fluoridation, reduction, and decarboxylation steps. Another approach involves synthesizing it from hexamidine. These complex synthesis methods ensure the production of a high-quality intermediate ready for further chemical reactions.

As a leading manufacturer and supplier of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. offers a reliable source for 2,4,5-Trifluorobenzoic acid. We pride ourselves on consistent product quality and efficient supply chain management. For those looking to buy or purchase this essential intermediate, we provide competitive price options tailored to varying order volumes. Our commitment is to facilitate your research and production needs with a consistent supply of high-purity chemical intermediates. We are ready to serve as your dedicated supplier for this critical compound, ensuring timely delivery and comprehensive technical support.