4-Hydroxy-2-methylquinoline (CAS 607-67-0) stands as a significant chemical compound, vital for numerous synthetic pathways across various industries. This heterocyclic compound, also known by synonyms such as 2-methyl-1H-quinolin-4-one, 4-Quinolinol, 2-methyl-, 2-Methyl-4-quinolinol, and 4-hydroxyquinaldine, boasts a molecular formula of C10H9NO and a molecular weight of approximately 159.18 g/mol. Its unique chemical structure and reactivity make it an indispensable building block in the development of complex molecules.
The physical and chemical properties of 4-Hydroxy-2-methylquinoline are well-defined, underscoring its utility in controlled chemical reactions. It typically presents as a white or off-white powder, though it can also appear as a beige solid or pale cream to pale brown powder/crystal, depending on the specific grade and preparation. Its melting point ranges consistently between 234-236 °C, with some literature reporting a range of 230-233 °C. The boiling point is noted at 270.8 °C at 760 mmHg, and it has a flash point of 120.1±27.5 °C. With a density of 1.136 g/cm3 and a refractive index of 1.573, its inherent stability and characteristics are suitable for industrial applications. It is observed to be slightly soluble in water, a characteristic that influences its handling and processing.
Quality and purity are paramount for intermediates like 4-Hydroxy-2-methylquinoline, especially when used in sensitive applications such as pharmaceuticals. Reputable specifications demand a purity exceeding 99%, ensuring minimal impurities and consistent performance in downstream synthesis. Water content is typically maintained at a low level, usually less than 0.5%, to preserve the compound's integrity and reactivity. Proper storage is crucial for maintaining its quality; it should be kept in a well-closed container at a low temperature, away from moisture, heat, and light, and specifically away from oxidizing agents to prevent degradation.
The applications of 4-Hydroxy-2-methylquinoline are diverse and critical, spanning from the pharmaceutical sector to cutting-edge material science. One of its primary roles is as an essential intermediate in the synthesis of Dequalinium chloride (CAS: 522-51-0), a pharmaceutical active ingredient known for its antiseptic properties. Beyond this, its quinoline scaffold makes it highly valuable as a broader pharmaceutical intermediate for the development of new drug candidates. Quinoline derivatives are often bioactive, and this compound serves as a versatile starting material for tailoring active pharmaceutical ingredients, including those for bioimaging applications where fluorescent properties can be utilized to monitor cellular activities in vitro.
Furthermore, 4-Hydroxy-2-methylquinoline plays a significant role in the field of advanced materials, particularly in the creation of organic light-emitting diodes (OLEDs) and dye-sensitized solar cells (DSSCs). Its conjugated molecular structure can be readily modified to tune the energy gap, making it an excellent candidate for synthesizing dyes used in these optoelectronic devices. The compound's versatility and the ability to introduce various functional groups enable facile reactions such as nucleophilic substitution and enamine condensation with aldehydes, further expanding its utility in materials synthesis. This broad applicability solidifies its position as a key building block for both established and emerging technologies.
For industries seeking reliable supply of high-purity 4-Hydroxy-2-methylquinoline, partnering with a knowledgeable manufacturer and supplier is essential. When considering to buy or purchase this vital chemical, it is advisable to inquire about bulk price options and ensure that the product meets stringent quality standards for your specific research or production needs. A dependable source will provide comprehensive technical information and adhere to strict packaging and storage guidelines, typically offering the product in 25kg cardboard drums or tailored to customer requirements, ensuring its integrity upon arrival and throughout its shelf life.
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