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Essential Intermediate: Ethyl 1-Cyclopropyl-6,7-Difluoro-Quinolone Ester

Ethyl 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylate, identified by its CAS number 112811-71-9, stands as a pivotal compound in the synthesis of advanced pharmaceutical drugs. As a key intermediate, its high purity and consistent quality are paramount for downstream applications in the pharmaceutical industry. NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a reliable supplier of this critical chemical, ensuring it meets the stringent demands of global manufacturers.


This organic compound, also known by synonyms such as Gatifloxacin Cyclization Ester, Ethyl 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate, and Gati Ester, possesses the molecular formula C16H15F2NO4 and a molecular weight of 323.29100. Its physical and chemical properties include a density of 1.414g/cm³, a boiling point of 459.7ºC at 760mmHg, a melting point of 179-181ºC, a flash point of 231.8ºC, and a refractive index of 1.578. Typically, it appears as a white or off-white crystalline powder, indicative of its high purity and well-defined structure.


The quality specifications for Ethyl 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylate are meticulously controlled by NINGBO INNO PHARMCHEM CO.,LTD. Each batch is rigorously tested to ensure a purity of ≥99%. Furthermore, strict limits are maintained for heavy metals (≤10ppm), arsenic (≤1ppm), lead (≤3ppm), mercury (≤0.1ppm), and cadmium (≤1ppm), underscoring our commitment to safety and efficacy in pharmaceutical synthesis. Microbiological parameters are also monitored, with total plate count ≤1000cfu/g and yeast & mold ≤100cfu/g, guaranteeing a product suitable for sensitive applications.


The primary application of this compound is as an essential intermediate in the production of fluoroquinolone antibiotics, specifically Moxifloxacin hydrochloride (CAS: 186826-86-8), Moxifloxacin (CAS: 151096-09-2), and Gatifloxacin (CAS: 112811-59-3). These antibiotics are widely used in treating various bacterial infections, highlighting the compound's significant role in modern medicine. Its precise molecular structure contributes directly to the efficacy and safety profiles of these vital drugs.


For packaging, the standard is a 25kg cardboard drum, though NINGBO INNO PHARMCHEM CO.,LTD. can accommodate customer-specified requirements. Proper storage is crucial to maintain product integrity: it should be stored in a cool, dry, and well-closed container, kept away from moisture and strong light/heat. Adhering to these storage conditions ensures the chemical remains stable and effective over time, preserving its high quality for the end-user.


As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality Ethyl 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylate to the global market. We offer competitive price options and flexible supply solutions to meet diverse industry needs. Whether you are looking to buy or purchase in bulk or require specific quantities, our professional team is ready to assist with your inquiries. Our robust supply chain and commitment to quality make us the preferred partner for this indispensable pharmaceutical intermediate.

Manufacturing Facilities

NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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Should you need to contact us; you may call during regular business hours, Monday through Friday, 8am – 6 pm.
NINGBO INNO PHARMCHEM CO.,LTD.
Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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