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6-Aminouracil: A Versatile Pharmaceutical Intermediate and Key Building Block

6-Aminouracil (CAS 873-83-6) stands as a pivotal compound in the realm of pharmaceutical chemistry, recognized for its distinctive molecular structure and broad utility. With a molecular formula of C4H5N3O2 and a molecular weight of 127.1, this compound typically presents as a yellowish crystalline powder, distinguished by its high purity, commonly exceeding 99%.


Primarily, 6-Aminouracil serves as an indispensable pharmaceutical intermediate in the synthesis of well-known and widely used medications such as caffeine, theophylline, and sulfadimidine (SDM). Its unique chemical reactivity and stable pyrimidine core make it a highly desirable precursor for creating diverse drug molecules. Its reliability and consistent quality are paramount, ensuring the integrity and efficacy of the final pharmaceutical products.


Beyond its traditional applications, recent scientific advancements highlight 6-Aminouracil's immense potential as a versatile building block for novel drug discovery. Extensive research has explored its role in synthesizing various fused and related heterocyclic compounds, particularly in the development of new anticancer agents. Studies have demonstrated that derivatives synthesized from 6-Aminouracil can exhibit potent cytotoxic effects against prostate cancer cell lines, such as PC3. This makes 6-Aminouracil a starting material of significant interest for oncology research.


A critical area of investigation involves the evaluation of 6-Aminouracil derivatives as inhibitors of Cathepsin B, an enzyme strongly implicated in tumor invasion and metastasis, particularly in prostate cancer. Compounds derived from 6-Aminouracil, including certain furan, quinoxaline, thiazolidinone, and phenyl thiourea derivatives, have shown remarkable ability to inhibit Cathepsin B activity. In some instances, these synthesized compounds have demonstrated superior inhibitory effects compared to reference drugs, underscoring the promising therapeutic avenues that 6-Aminouracil unlocks. This versatility in forming various heterocyclic rings, whether directly attached or through amino/imino bridges to the uracil backbone, underscores its importance in creating diverse chemical libraries for screening against complex biological targets.


At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical role that high-quality intermediates play in driving pharmaceutical innovation. Our commitment to excellence ensures that our 6-Aminouracil is manufactured under stringent quality control standards, guaranteeing exceptional purity and consistent performance for all your synthesis and research needs. We are dedicated to being a reliable manufacturer and supplier of this crucial chemical intermediate.


For those looking to buy 6-Aminouracil or seeking comprehensive information regarding its price, NINGBO INNO PHARMCHEM CO.,LTD. stands ready to meet your demands. Our robust supply chain and customer-centric approach ensure a seamless purchase experience, delivering the highest quality 6-Aminouracil to support your scientific breakthroughs. Contact us today to learn more about our offerings and how we can facilitate your research and production goals.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

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  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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