In the dynamic landscape of pharmaceutical development, the availability of high-quality intermediates is paramount. Among these critical components is N-(4,5-Dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-4'-(hydroxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide, identified by its Chemical Abstracts Service (CAS) number 1098924-76-5. This compound plays a pivotal role in the synthesis of advanced pharmaceutical drugs, particularly as a key intermediate for Sparsentan. Its precise molecular structure and chemical properties make it indispensable for achieving the desired purity and efficacy of the final active pharmaceutical ingredient (API).

Known by various synonyms, including Sparsentan Impurity 5 or Sparsentan Alcohol Impurity, this substance possesses a unique chemical identity. Its molecular formula is C23H28N2O6S, with a molecular weight of 460.54 g/mol. Understanding its physical and chemical properties is crucial for its handling and application in synthesis processes. Predicted values indicate a boiling point of approximately 653.6±65.0 °C and a density of 1.267±0.06 g/cm3. The pKa value, predicted at 12.89±0.10, further defines its behavior in various chemical reactions. These characteristics are fundamental for chemists and researchers in designing efficient and safe synthetic routes.

The primary application of CAS 1098924-76-5 lies in its function as a vital intermediate for Sparsentan. Sparsentan is an important medication, and its production demands intermediates of exceptional quality and consistency. As a precursor, this compound directly influences the yield, purity, and overall quality of the end-product. The precise control over its synthesis and purification is therefore non-negotiable for pharmaceutical manufacturers aiming to produce therapeutic agents that meet stringent regulatory standards worldwide.

Beyond its direct role in synthesis, CAS 1098924-76-5 is also invaluable in pharmaceutical quality control and analytical applications. It serves as a reference standard for analytical method development (AMD) and method validation (AMV). In the context of Abbreviated New Drug Applications (ANDA) or during commercial production, it is utilized for crucial quality control (QC) applications. Ensuring the purity of pharmaceutical products means carefully monitoring for impurities, and this compound, even if present as an impurity, requires accurate quantification and characterization. Its use as a standard facilitates robust testing procedures, guaranteeing that finished drug products are safe and effective for patient use.

The demand for high-grade pharmaceutical intermediates necessitates a commitment to excellence in manufacturing. A reliable manufacturer and supplier understands the critical nature of these materials for research and large-scale production. Adherence to strict quality management systems is paramount to producing compounds like CAS 1098924-76-5 with consistent purity and identity. Products are often supplied with comprehensive characterization data, ensuring compliance with regulatory guidelines and facilitating their seamless integration into various pharmaceutical processes. Whether for industrial use, laboratory reagents, or analytical standards, quality is maintained through rigorous testing and quality assurance protocols.

For those looking to buy or purchase this essential intermediate, it is crucial to partner with a supplier that can meet diverse requirements, from small quantities for research and development to bulk orders for commercial manufacturing. Discussions around price often involve considerations of purity, packaging (e.g., 1kg, drums), and specific customization needs. Many suppliers offer flexibility, including options for custom synthesis, to precisely match the unique specifications of a project. This adaptability ensures that researchers and pharmaceutical companies have access to the exact grade and quantity required, supporting innovation and efficient production cycles.

In summary, N-(4,5-Dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-4'-(hydroxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide (CAS 1098924-76-5) stands as a foundational chemical in modern pharmacology. Its dual role as a crucial intermediate for Sparsentan and as a vital analytical reference standard underscores its significance. Access to a high-quality product from a reputable manufacturer and supplier is key for driving progress in drug discovery and ensuring patient safety. Those seeking to acquire this essential compound can find competitive price options and reliable supply channels, whether for immediate purchase or long-term partnership.