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The pharmaceutical industry's relentless pursuit of novel and more effective treatments for cardiovascular diseases has led to a growing reliance on advanced chemical synthesis techniques. Within this domain, fluorinated organic compounds have emerged as particularly valuable building blocks, thanks to fluorine's unique ability to modulate molecular properties such as lipophilicity, metabolic stability, and target binding affinity. A prime example of such a critical intermediate is (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol (CAS 1006376-60-8).
This chiral intermediate is instrumental in the synthesis of Ticagrelor, a groundbreaking P2Y12 receptor antagonist that offers significant advantages in treating patients with acute coronary syndromes. The difluorophenyl moiety within (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol contributes to the pharmacological profile of Ticagrelor, enhancing its potency and pharmacokinetic characteristics. For pharmaceutical companies, ensuring a consistent and high-quality supply of this intermediate is therefore paramount for uninterrupted production and therapeutic development.
Procurement managers and research scientists frequently seek to purchase this intermediate from reliable manufacturers. When sourcing, it is crucial to partner with suppliers who can guarantee exceptional purity and stereochemical integrity, as these factors directly impact the efficacy and safety of the final drug product. Reputable manufacturers, particularly those based in China, often provide detailed analytical data, including CAS details, molecular formula (C8H7ClF2O), and purity reports, which are essential for quality assurance.
When evaluating suppliers for (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol, potential buyers should consider factors such as production capacity, pricing structures (e.g., price per kilogram), and logistical capabilities for global delivery. Establishing a supply agreement with a trusted manufacturer ensures not only cost-effectiveness but also a stable supply chain, which is vital for meeting market demands for cardiovascular medications.
In conclusion, the strategic use of fluorinated chemical building blocks like (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol is central to the development of next-generation cardiovascular drugs. By prioritizing quality, reliability, and collaborative relationships with expert manufacturers, pharmaceutical companies can effectively leverage these advanced intermediates to bring innovative treatments to patients worldwide.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
