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In the realm of pharmaceutical synthesis, understanding the precise chemical properties and efficient synthesis routes of key intermediates is fundamental. (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol (CAS 1006376-60-8) exemplifies such a critical component, widely recognized for its role in producing sophisticated APIs like Ticagrelor. For professionals in chemical procurement and research, a thorough grasp of this compound's attributes is essential for successful sourcing and application.
The chemical profile of (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol is characterized by its molecular formula C8H7ClF2O and a molecular weight of approximately 192.59 g/mol. Its physical appearance is noted as a clear, almost colorless viscous liquid. Key chemical properties include a predicted boiling point of 256.3±35.0 °C and a density of 1.372±0.06 g/cm³. It exhibits slight solubility in chloroform and methanol, and its stability under specific storage conditions (2-8°C) is important for maintaining its integrity.
The synthesis of (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol typically involves precursors such as 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone, with 1,2-Difluorobenzene being a related raw material. The process often aims to achieve high enantiomeric purity, which is crucial for its application in chiral synthesis. Researchers looking to buy this intermediate should prioritize suppliers who can provide documentation confirming these synthesis details and purity levels.
For procurement managers, identifying reliable manufacturers and suppliers is a critical step in ensuring a consistent supply chain for their API production. When searching for (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol, comparing quotes and product specifications from various China-based chemical manufacturers is a standard practice. This ensures competitive pricing and facilitates the procurement of a vital component for drug development.
Moreover, the utility of this compound extends beyond Ticagrelor synthesis; it serves as a versatile chiral building block in broader organic synthesis applications. Therefore, having access to a dependable supplier who can consistently deliver this intermediate allows research and development teams to explore new synthetic pathways and drug candidates efficiently. Ultimately, a well-managed sourcing strategy for intermediates like (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol underpins the successful and cost-effective manufacturing of essential pharmaceuticals.
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