Cefotiam Powder, identified by its CAS number 61622-34-2, stands as a critical second-generation cephalosporin antibiotic, widely recognized for its robust efficacy in combating a diverse range of bacterial infections. As a leading manufacturer and supplier of pharmaceutical raw materials, NINGBO INNO PHARMCHEM CO.,LTD. is proud to offer this high-purity, GMP-certified active pharmaceutical ingredient (API), essential for the global healthcare industry.

This potent compound typically presents as a white or slightly yellow powder, possessing a high purity exceeding 99%. Its chemical formula, C18H23N9O4S3, and molecular weight of 525.62800 underscore its complex structure, which is designed for targeted antibacterial action. Cefotiam Powder functions as a beta-lactam antibiotic, a class renowned for its effective inhibition of bacterial cell wall synthesis. This mechanism involves binding to specific penicillin-binding proteins (PBPs) within the bacterial structure. By interfering with the crucial cross-linking of peptidoglycan chains—components vital for cell wall strength and integrity—Cefotiam leads to the weakening and eventual lysis, or death, of the bacterial cell. This mode of action ensures its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it a versatile choice in clinical practice.

The therapeutic applications of Cefotiam Powder are extensive. It is frequently indicated for the treatment of various severe infections, including those affecting the respiratory system such as pneumonia, bronchitis, tonsillitis, and empyema. It is also highly effective against urinary tract infections like pyelonephritis and cystitis, and skin and soft tissue infections including subcutaneous abscesses and burn infections. Furthermore, Cefotiam proves invaluable in addressing bone and joint infections (e.g., osteomyelitis), biliary tract infections (e.g., cholangitis), and infections within the reproductive system. Its utility extends to life-threatening conditions such as sepsis, meningitis, and peritonitis, as well as postoperative infections, highlighting its critical role in modern medicine.

Administered typically via intramuscular injection or intravenous infusion, Cefotiam Powder exhibits a relatively rapid onset of action, often within 30 to 60 minutes after administration, which is crucial for acute bacterial infections. While generally well-tolerated, it is important to note potential side effects, which commonly include gastrointestinal disturbances like diarrhea, nausea, and vomiting. Allergic reactions, although less common, can range from rash to more severe anaphylaxis. Patients may also experience pain or inflammation at the injection site. More severe, yet rare, adverse effects can include hematologic reactions and potential renal or hepatic impairment, particularly in individuals with pre-existing conditions.

Careful consideration of drug interactions is vital for optimal patient outcomes. Concomitant use with nephrotoxic drugs, such as aminoglycosides or potent diuretics like furosemide, can heighten the risk of renal toxicity, necessitating close monitoring of renal function. Probenecid, an anti-gout medication, can increase Cefotiam's plasma concentration by inhibiting its renal excretion, which may require dosage adjustment. Additionally, co-administration with anticoagulants like warfarin could increase bleeding risk, while live bacterial vaccines may have reduced efficacy if given concurrently.

NINGBO INNO PHARMCHEM CO.,LTD. is a reliable manufacturer and supplier dedicated to providing high-quality Cefotiam Powder for diverse pharmaceutical needs. For those looking to purchase Cefotiam Powder or inquire about its price, we ensure a consistent supply of this essential API. Our commitment to excellence makes us a preferred choice for companies seeking a trusted Cefotiam Powder supplier with competitive offerings. To buy Cefotiam Powder, or to understand more about its specifications and our manufacturing capabilities, please contact us directly. We are ready to support your production requirements with a superior product.