Cisatracurium Besilate, identified by its CAS number 96946-42-8, stands as a cornerstone Active Pharmaceutical Ingredient (API) within modern anesthesiology and critical care medicine. This compound is a highly selective, non-depolarizing neuromuscular blocking agent, widely recognized for its predictable pharmacokinetics and minimal histamine release, making it a preferred choice for inducing muscle relaxation during surgical procedures and facilitating mechanical ventilation in intensive care units.

Chemically, Cisatracurium Besilate is a stereoisomer of atracurium, belonging to the benzylisoquinolinium class of muscle relaxants. Its unique metabolic profile, undergoing Hofmann elimination at physiological pH and temperature, contributes to its organ-independent clearance. This characteristic is particularly advantageous in patients with renal or hepatic impairment, as the drug's elimination is not significantly affected by the function of these organs. This reliability in diverse patient populations underscores its value in clinical settings where precise control over muscle paralysis is paramount.

As an API, Cisatracurium Besilate typically presents as a white or almost white crystalline powder. This solid form is essential for its formulation into injectable solutions, the final dosage form administered to patients. The purity and quality of the API are critically important to ensure the safety and efficacy of the resulting pharmaceutical product. High standards of manufacturing practice, such as those adhering to GMP guidelines, are indispensable in the production of this sensitive compound.

The primary application of Cisatracurium Besilate is in providing skeletal muscle relaxation for surgical procedures, enabling tracheal intubation, and reducing muscle contractions during mechanical ventilation in the intensive care unit. It works by competitively binding to nicotinic acetylcholine receptors at the neuromuscular junction, thereby blocking the transmission of nerve impulses to muscles. The onset and duration of action are dose-dependent, allowing clinicians to tailor the level of muscle blockade to the specific needs of the patient and the procedure.

The API's consistent quality, often exceeding 99% assay, is a key factor for pharmaceutical manufacturers. Ensuring this high level of purity requires rigorous quality control procedures throughout the synthesis and purification process. From raw material sourcing to final product testing, every step must be meticulously controlled to eliminate impurities that could affect the stability, safety, or efficacy of the final drug product.

Packaging of Cisatracurium Besilate API is designed to maintain its integrity and stability. Common packaging includes cardboard drums or cartons, suitable for various quantities ranging from grams for research and development or small-scale formulation to kilograms for large-scale pharmaceutical production. The stability of the API is generally good under recommended storage conditions, contributing to its suitability for global distribution and manufacturing.

Production capacity is a vital consideration for pharmaceutical companies relying on a steady supply of APIs. Manufacturers capable of producing significant quantities, such as 50kg per month as sometimes indicated, play a crucial role in meeting the global demand for essential medications. Reliability in supply chain management is as important as the quality of the product itself.

Quality guarantee periods, often extending to 24 months or more when stored properly, further enhance the appeal of Cisatracurium Besilate API to pharmaceutical formulators. This extended shelf life provides flexibility in production planning and inventory management, reducing the risk of product degradation before use.

For pharmaceutical companies seeking a dependable source of high-quality Cisatracurium Besilate API (CAS 96946-42-8), finding a reputable supplier is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing pharmaceutical chemicals that meet stringent international standards. As a key manufacturer and supplier in the market, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical requirements of the pharmaceutical industry, offering Cisatracurium Besilate API with guaranteed quality and purity. When considering the price and logistics for large-scale purchase, engaging directly with a manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to detailed product specifications, quality documentation, and competitive pricing. Companies looking to buy or purchase Cisatracurium Besilate can rely on NINGBO INNO PHARMCHEM CO.,LTD. for consistent quality and professional service, facilitating the smooth development and production of vital pharmaceutical products for global healthcare needs.